4-Fluoro-3-hydroxybenzyl alcohol

Product Name: 4-Fluoro-3-hydroxybenzyl alcohol
CAS No.: 934241-78-8
Chemical Name: 4-Fluoro-3-hydroxybenzyl alcohol
Synonyms: 2-Fluoro-5-(hydroxymethyl)phenol;4-Fluoro-3-hydroxybenzyl alcohol;Benzenemethanol, 4-fluoro-3-hydroxy-;2-Fluoro-5-(hydroxymethyl)phenol 95+%
CBNumber: CB93154530
Molecular Formula: C7H7FO2
Formula Weight: 142.13
MOL File: 934241-78-8.mol

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4-Fluoro-3-hydroxybenzyl alcohol Property

Boiling point:: 272.4±25.0 °C(Predicted)
Density: 1.342±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 8.49±0.10(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2908190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F600185
Product name: 2-Fluoro-5-(hydroxymethyl)phenol
Packaging: 2.5g
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: PC53135
Product name: 2-Fluoro-5-(hydroxymethyl)phenol
Purity: 95+%
Packaging: 5g
Price: $779
Updated: 2021/12/16

Apolloscientific

Product number: PC53135
Product name: 2-Fluoro-5-(hydroxymethyl)phenol
Purity: 95+%
Packaging: 250mg
Price: $87
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2604-3-16
Product name: 2-Fluoro-5-(hydroxymethyl)phenol
Packaging: 250mg
Price: $96
Updated: 2021/12/16

Apolloscientific

Product number: PC53135
Product name: 2-Fluoro-5-(hydroxymethyl)phenol
Purity: 95+%
Packaging: 1g
Price: $217
Updated: 2021/12/16

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4-Fluoro-3-hydroxybenzyl alcohol Chemical Properties,Usage,Production

Synthesis

214822-96-5

934241-78-8

The general procedure for the synthesis of 4-fluoro-3-hydroxybenzyl alcohol from methyl 4-fluoro-3-hydroxybenzoate was as follows: LiBH4 (2.37 g, 109 mmol) was suspended in THF (50 mL) at room temperature, followed by the addition of methyl 4-fluoro-3-hydroxybenzoate (5.0 g, 27.2 mmol). The reaction mixture was stirred under reflux conditions for 24 hours. After completion of the reaction, the mixture was concentrated. The residue was partitioned between EtOAc (100 mL) and 1N HCl (100 mL). The aqueous layer was extracted with EtOAc (50 mL × 2) and the combined organic layers were washed with brine, dried over MgSO4 and concentrated. The residue was purified by fast column chromatography to afford 4-fluoro-3-hydroxybenzyl alcohol (2.76 g, 19.4 mmol, 66% yield) as a white solid.1H NMR (CDCl3) δ: 7.09-7.00 (2H, m), 6.88-6.82 (1H, m), 5.24 (1H, d, J = 4.0 Hz), 4.60 (2H, s) , 1.68 (1H, brs).

References

[1] Patent: US2011/136801, 2011, A1. Location in patent: Page/Page column 64

4-Fluoro-3-hydroxybenzyl alcohol Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Fluoro-3-hydroxybenzyl alcohol Suppliers

China 26 India 1 United Kingdom 1 United States 4 Global 32

Amadis Chemical Company Limited

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934241-78-8, 4-Fluoro-3-hydroxybenzyl alcoholRelated Search:

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934241-78-8