4-Fluoro-3-hydroxybenzyl alcohol
- Product Name
- 4-Fluoro-3-hydroxybenzyl alcohol
- CAS No.
- 934241-78-8
- Chemical Name
- 4-Fluoro-3-hydroxybenzyl alcohol
- Synonyms
- 2-Fluoro-5-(hydroxymethyl)phenol;4-Fluoro-3-hydroxybenzyl alcohol;Benzenemethanol, 4-fluoro-3-hydroxy-;2-Fluoro-5-(hydroxymethyl)phenol 95+%
- CBNumber
- CB93154530
- Molecular Formula
- C7H7FO2
- Formula Weight
- 142.13
- MOL File
- 934241-78-8.mol
4-Fluoro-3-hydroxybenzyl alcohol Property
- Boiling point:
- 272.4±25.0 °C(Predicted)
- Density
- 1.342±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 8.49±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2908190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F600185
- Product name
- 2-Fluoro-5-(hydroxymethyl)phenol
- Packaging
- 2.5g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC53135
- Product name
- 2-Fluoro-5-(hydroxymethyl)phenol
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $87
- Updated
- 2021/12/16
- Product number
- 2604-3-16
- Product name
- 2-Fluoro-5-(hydroxymethyl)phenol
- Packaging
- 250mg
- Price
- $96
- Updated
- 2021/12/16
- Product number
- PC53135
- Product name
- 2-Fluoro-5-(hydroxymethyl)phenol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $217
- Updated
- 2021/12/16
- Product number
- 2604-3-16
- Product name
- 2-Fluoro-5-(hydroxymethyl)phenol
- Packaging
- 1g
- Price
- $239
- Updated
- 2021/12/16
4-Fluoro-3-hydroxybenzyl alcohol Chemical Properties,Usage,Production
Synthesis
214822-96-5
934241-78-8
The general procedure for the synthesis of 4-fluoro-3-hydroxybenzyl alcohol from methyl 4-fluoro-3-hydroxybenzoate was as follows: LiBH4 (2.37 g, 109 mmol) was suspended in THF (50 mL) at room temperature, followed by the addition of methyl 4-fluoro-3-hydroxybenzoate (5.0 g, 27.2 mmol). The reaction mixture was stirred under reflux conditions for 24 hours. After completion of the reaction, the mixture was concentrated. The residue was partitioned between EtOAc (100 mL) and 1N HCl (100 mL). The aqueous layer was extracted with EtOAc (50 mL × 2) and the combined organic layers were washed with brine, dried over MgSO4 and concentrated. The residue was purified by fast column chromatography to afford 4-fluoro-3-hydroxybenzyl alcohol (2.76 g, 19.4 mmol, 66% yield) as a white solid.1H NMR (CDCl3) δ: 7.09-7.00 (2H, m), 6.88-6.82 (1H, m), 5.24 (1H, d, J = 4.0 Hz), 4.60 (2H, s) , 1.68 (1H, brs).
References
[1] Patent: US2011/136801, 2011, A1. Location in patent: Page/Page column 64
4-Fluoro-3-hydroxybenzyl alcohol Preparation Products And Raw materials
Raw materials
Preparation Products
4-Fluoro-3-hydroxybenzyl alcohol Suppliers
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- Country
- United Kingdom
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