ChemicalBook > CAS DataBase List > ATI-2341
ATI-2341
- Product Name
- ATI-2341
- CAS No.
- 1337878-62-2
- Chemical Name
- ATI-2341
- Synonyms
- ATI-2341;ATI-2341 ，S8309;ATI 2341;ATI2341;Palmitoyl-L-methionylglycyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-lysyl-L-leucyl-L-arginyl-L-seryl-L-methionyl-L-threonyl-L-aspartyl-L-lysyl-L-tyrosyl-L-arginyl-L-leucine;L-Leucine, N-(1-oxohexadecyl)-L-methionylglycyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-lysyl-L-leucyl-L-arginyl-L-seryl-L-methionyl-L-threonyl-L-α-aspartyl-L-lysyl-L-tyrosyl-L-arginyl-
- CBNumber
- CB93159454
- Molecular Formula
- C104H178N26O25S2
- Formula Weight
- 2256.85
- MOL File
- 1337878-62-2.mol
More
Less
ATI-2341 Property
- Density
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- film
- color
- colorless
- Water Solubility
- Soluble to 1 mg/ml in water
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML1720
- Product name
- ATI-2341 trifluoroacetate salt
- Purity
- ≥95% (HPLC)
- Packaging
- 1 mg
- Price
- $241
- Updated
- 2025/07/31
Tocris
- Product number
- 5795
- Product name
- ATI2341
- Packaging
- 1
- Price
- $227
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B7814
- Product name
- ATI-2341
- Packaging
- 1mg
- Price
- $221
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B7814
- Product name
- ATI-2341
- Packaging
- 10mg
- Price
- $614
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B7814
- Product name
- ATI-2341
- Packaging
- 5mg
- Price
- $614
- Updated
- 2021/12/16
More
Less
ATI-2341 Chemical Properties,Usage,Production
Biological Activity
ati-2341 is a cxcr4 allosteric agonist.chemokine cxc-type receptor 4 (cxcr4) and its ligand cxcl12 mediate the retention of polymorphonuclear neutrophils and hematopoietic stem and progenitor cells in the bone marrow. drugs disrupting cxcl12-mediated chemoattraction of cxcr4-expressing cells are useful for hematopoietic stem and progenitor cells (hspcs) collection.
in vitro
ati-2341 could inhibit nkh477-induced camp accumulation in cxcr4-hek cells dose-dependently, but showed no effect in naive hek-293 parental cells. pretreatment of cxcr4- hek cells with pertussis toxin completely abrogated the ability of ati-2341 to inhibit camp accumulation. ati-2341 could also induce a dose-dependent increase in intracellular calcium in cells transfected with wild-type cxcr4 whereas having no effect on untransfected cells. activation of such signaling pathway by ati-2341 was dependent on a fully functional cxcr4 receptor since ati-2341 was not able to mobilize calcium in cells transfected with a cxcr4 receptor variant [1].
in vivo
ati-2341 could induce dose-dependent peritoneal recruitment of polymorphonuclear neutrophils (pmns) when i.p. administered to mice. however, when systemically administered by i.v. bolus, ati-2341 acted as an antagonist and could dose-dependently mediate release of pmns from the bone marrow of mice and cynomolgus monkeys. in addition, ati-2341-mediated release of granulocyte/macrophage progenitor cells from the bone marrow was further confirmed by colony-forming assays [1].
target
| Target | Value |
| CXCR4 (in CCRF-CEM cells) | < td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 194 nM(EC50)
IC 50
194 nm
storage
Store at -20°C
References
[1] tchernychev b et al. discovery of a cxcr4 agonist pepducin that mobilizes bone marrow hematopoietic cells. proc natl acad sci u s a.2010 dec 21;107(51):22255-9.
ATI-2341 Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
ATI-2341 Suppliers
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15178
- Advantage
- 58
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2990
- Advantage
- 60
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8000
- Advantage
- 62
- Tel
- 010-50973130 18101056239
- 3193328036@qq.com
- Country
- China
- ProdList
- 29759
- Advantage
- 68
- Tel
- +86-17380623303
- Fax
- 028-62328193
- Caroline@youngshechem.com
- Country
- China
- ProdList
- 4802
- Advantage
- 58
- Tel
- 0571-87213919
- Eric@peptidego.com
- Country
- China
- ProdList
- 7408
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9729
- Advantage
- 58
- Tel
- 020-31155029 18902330969
- Fax
- 020-31155029
- sales@tomums.cn
- Country
- China
- ProdList
- 4696
- Advantage
- 58
- Tel
- +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58
- Tel
- 86-571-88216897,88216896 13588875226
- Fax
- 86-571-88216895
- sales@hzclap.com
- Country
- CHINA
- ProdList
- 6312
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30229
- Advantage
- 58
- Tel
- 18108052721
- 2850505130@qq.com
- Country
- China
- ProdList
- 5167
- Advantage
- 58
- Tel
- +8619521488211
- Fax
- +86 15821988213
- info@longyupharma.com
- Country
- China
- ProdList
- 2541
- Advantage
- 58
- Tel
- 021-38015121 18438616290
- lanwu@univ-bio.com
- Country
- China
- ProdList
- 24731
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 13758194781 13173652190
- 522013271@qq.com
- Country
- China
- ProdList
- 2395
- Advantage
- 58
- Tel
- 0510-85629785 18013409632
- Fax
- 0510-85625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 14081
- Advantage
- 58
- Tel
- 15397062932
- sales1@gotopbio.com
- Country
- China
- ProdList
- 2923
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44894
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29757
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 59936
- Advantage
- 58
- Tel
- 13549236410
- sales@invivochem.cn
- Country
- China
- ProdList
- 6753
- Advantage
- 58
- Tel
- 0571-0571-88211921 19105816207
- sales4@gotopbio.com
- Country
- China
- ProdList
- 5144
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24961
- Advantage
- 58
- Tel
- 0571-87213919 17306812703
- 3007955328@qq.com
- Country
- China
- ProdList
- 6979
- Advantage
- 58
- Tel
- 0571-85350119 15888826472
- 15888826472@163.com
- Country
- China
- ProdList
- 2729
- Advantage
- 58
- Tel
- 15318089928
- alex@hanhonggroup.com
- Country
- China
- ProdList
- 4604
- Advantage
- 58
- Tel
- 13770887460
- wenxi@jszkhy.com
- Country
- China
- ProdList
- 1354
- Advantage
- 58
- Tel
- 17751201929
- office@combiosz.com
- Country
- China
- ProdList
- 3000
- Advantage
- 58
- Tel
- 0571-88211951 13735575465
- sales1@gotopbio.com
- Country
- China
- ProdList
- 4880
- Advantage
- 58
- Tel
- 400-6206333 13167063860
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 48457
- Advantage
- 58
- Tel
- 0571-85350119 15888826472
- bptsales@163.com
- Country
- China
- ProdList
- 3834
- Advantage
- 58
- Tel
- 18003437475
- Fax
- 1-612-656-4400
- rdname@qq.com
- Country
- China
- ProdList
- 6960
- Advantage
- 58
- Tel
- 21-20338288
- ordercn@merckgroup.com
- Country
- China
- ProdList
- 6394
- Advantage
- 58
- Tel
- 51288865780
- sales@biosynth.com
- Country
- China
- ProdList
- 6051
- Advantage
- 58
- Tel
- 400-025-6535
- sales@adooq.cn
- Country
- China
- ProdList
- 6215
- Advantage
- 58
- Tel
- 400-668-6834
- info@selleck.cn
- Country
- China
- ProdList
- 6071
- Advantage
- 58
- Tel
- 19941518170
- sales@typeptide.com
- Country
- China
- ProdList
- 3920
- Advantage
- 58
- Tel
- 17342063383
- sales@allpeptide.com
- Country
- China
- ProdList
- 5320
- Advantage
- 58
- Tel
- 13758194781 15083780366
- wudegui@tanzhenbio.com
- Country
- China
- ProdList
- 1591
- Advantage
- 58
- Tel
- +undefined-21-51877795
- Fax
- +86 21 5161 9052/ 5187 7796
- ivan@atkchemical.com
- Country
- China
- ProdList
- 33024
- Advantage
- 60
- Tel
- +8619375158599
- info@molchanges.com
- Country
- China
- ProdList
- 5218
- Advantage
- 58
- Tel
- +86-755-89396905 +86-15013857715
- admin@nexconn.com
- Country
- China
- ProdList
- 10405
- Advantage
- 58
- Tel
- +86-571-87711850
- market18@leapchem.com
- Country
- China
- ProdList
- 24727
- Advantage
- 58
- Tel
- 17301778918
- Country
- CHINA
- ProdList
- 105
- Advantage
- 58
- Tel
- 18818417021
- Country
- CHINA
- ProdList
- 127
- Advantage
- 58
- Tel
- 18689410811
- Country
- CHINA
- ProdList
- 178
- Advantage
- 58
- Tel
- 19928332050
- Country
- CHINA
- ProdList
- 161
- Advantage
- 58
- Tel
- 15571990006
- Country
- CHINA
- ProdList
- 141
- Advantage
- 58