ChemicalBook > CAS DataBase List > ATI-2341
ATI-2341
- Product Name
- ATI-2341
- CAS No.
- 1337878-62-2
- Chemical Name
- ATI-2341
- Synonyms
- ATI-2341;ATI 2341;ATI2341;Palmitoyl-L-methionylglycyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-lysyl-L-leucyl-L-arginyl-L-seryl-L-methionyl-L-threonyl-L-aspartyl-L-lysyl-L-tyrosyl-L-arginyl-L-leucine;L-Leucine, N-(1-oxohexadecyl)-L-methionylglycyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-lysyl-L-leucyl-L-arginyl-L-seryl-L-methionyl-L-threonyl-L-α-aspartyl-L-lysyl-L-tyrosyl-L-arginyl-
- CBNumber
- CB93159454
- Molecular Formula
- C104H178N26O25S2
- Formula Weight
- 2256.85
- MOL File
- 1337878-62-2.mol
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ATI-2341 Property
- Density
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- Water Solubility
- Soluble to 1 mg/ml in water
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N-Bromosuccinimide Price
Tocris
- Product number
- 5795
- Product name
- ATI2341
- Packaging
- 1
- Price
- $227
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B7814
- Product name
- ATI-2341
- Packaging
- 10mg
- Price
- $614
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B7814
- Product name
- ATI-2341
- Packaging
- 5mg
- Price
- $614
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B7814
- Product name
- ATI-2341
- Packaging
- 1mg
- Price
- $221
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC9878
- Product name
- ATI-2341
- Purity
- >98%
- Packaging
- 100mg
- Price
- $1500
- Updated
- 2021/12/16
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ATI-2341 Chemical Properties,Usage,Production
Biological Activity
ati-2341 is a cxcr4 allosteric agonist.chemokine cxc-type receptor 4 (cxcr4) and its ligand cxcl12 mediate the retention of polymorphonuclear neutrophils and hematopoietic stem and progenitor cells in the bone marrow. drugs disrupting cxcl12-mediated chemoattraction of cxcr4-expressing cells are useful for hematopoietic stem and progenitor cells (hspcs) collection.
in vitro
ati-2341 could inhibit nkh477-induced camp accumulation in cxcr4-hek cells dose-dependently, but showed no effect in naive hek-293 parental cells. pretreatment of cxcr4- hek cells with pertussis toxin completely abrogated the ability of ati-2341 to inhibit camp accumulation. ati-2341 could also induce a dose-dependent increase in intracellular calcium in cells transfected with wild-type cxcr4 whereas having no effect on untransfected cells. activation of such signaling pathway by ati-2341 was dependent on a fully functional cxcr4 receptor since ati-2341 was not able to mobilize calcium in cells transfected with a cxcr4 receptor variant [1].
in vivo
ati-2341 could induce dose-dependent peritoneal recruitment of polymorphonuclear neutrophils (pmns) when i.p. administered to mice. however, when systemically administered by i.v. bolus, ati-2341 acted as an antagonist and could dose-dependently mediate release of pmns from the bone marrow of mice and cynomolgus monkeys. in addition, ati-2341-mediated release of granulocyte/macrophage progenitor cells from the bone marrow was further confirmed by colony-forming assays [1].
target
| Target | Value |
| CXCR4 (in CCRF-CEM cells) | < td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 194 nM(EC50)
IC 50
194 nm
storage
Store at -20°C
References
[1] tchernychev b et al. discovery of a cxcr4 agonist pepducin that mobilizes bone marrow hematopoietic cells. proc natl acad sci u s a.2010 dec 21;107(51):22255-9.
ATI-2341 Preparation Products And Raw materials
Raw materials
Preparation Products
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