N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide maleate
- Product Name
- N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide maleate
- CAS No.
- 1557268-88-8
- Chemical Name
- N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide maleate
- Synonyms
- AC0010;AC-0010;AC 0010.;Avitinib (maleate);Avitinib (AC0010) maleate;Abivertinib maleate Avitinib;Avitinib maleate, 10 mM in DMSO;AC0010MA; AC-0010MA; AC 0010MA; AC0010; AC-0010; AC 0010.;N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide maleate;HER1,Abivertinib,EGFR,Inhibitor,Avitinib,AC0010,Epidermal growth factor receptor,Avitinib maleate,inhibit,ErbB-1,AC-0010,AC 0010
- CBNumber
- CB93161956
- Molecular Formula
- C30H30FN7O6
- Formula Weight
- 603.6009032
- MOL File
- 1557268-88-8.mol
N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide maleate Property
- storage temp.
- Store at -20°C
- solubility
- DMSO:100.0(Max Conc. mg/mL);165.67(Max Conc. mM)
- form
- Solid
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- CS-6952
- Product name
- Avitinibmaleate
- Purity
- 99.17%
- Packaging
- 5mg
- Price
- $84
- Updated
- 2021/12/16
- Product number
- CS-6952
- Product name
- Avitinibmaleate
- Purity
- 99.17%
- Packaging
- 10mg
- Price
- $144
- Updated
- 2021/12/16
- Product number
- CS-6952
- Product name
- Avitinibmaleate
- Purity
- 99.17%
- Packaging
- 50mg
- Price
- $540
- Updated
- 2021/12/16
- Product number
- CS-6952
- Product name
- Avitinibmaleate
- Purity
- 99.17%
- Packaging
- 100mg
- Price
- $780
- Updated
- 2021/12/16
- Product number
- CM249788
- Product name
- N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamidemaleate
- Purity
- 97%
- Packaging
- 1g
- Price
- $926
- Updated
- 2021/12/16
N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide maleate Chemical Properties,Usage,Production
Uses
Avitinib (Abivertinib) maleate is a third-generation, irreversible and orally active selective EGFR inhibitor, with IC50 values of 0.18 nM, 0.18 nM, 7.68 nM and against EGFR L858R, EGFR T790M and wild-type EGFR. Avitinib maleate is also a BTK inhibitor that induces apoptosis and inhibits phosphorylation of BTK in mantle cell lymphoma. Avitinib maleate shows anticancer effects[1][2].
in vivo
Avitinib (AC0010; 12.5-500 mg/kg; orally administration; once daily; for 14 days) maleate inhibits EGFR-mutant tumor growth but not wild-type EGFR tumor growth in xenograft models over extended duration[1].
| Animal Model: | Nu/Nu nude mice (Six- to 8-week-old) injected with NCI-H1975 and A431 cells[1] |
| Dosage: | 12.5, 50, and 500 mg/kg |
| Administration: | Orally administration; once daily; for 14 days |
| Result: | Inhibited EGFR-mutant tumor growth but not wild-type EGFR tumor growth. |
IC 50
EGFR L858R: 0.18 nM (IC50); EGFRT790M: 0.18 nM (IC50); EGFR (WT): 7.68 nM (IC50)
References
[1] Xu X, et al. AC0010, an Irreversible EGFR Inhibitor Selectively Targeting Mutated EGFR and Overcoming T790M-Induced Resistance in Animal Models and Lung Cancer Patients. Mol Cancer Ther. 2016 Nov;15(11):2586-2597. DOI:10.1158/1535-7163.MCT-16-0281
[2] Yan X, et al. Promising efficacy of novel BTK inhibitor AC0010 in mantle cell lymphoma. J Cancer Res Clin Oncol. 2018;144(4):697-706. DOI:10.1007/s00432-017-2570-8
N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide maleate Preparation Products And Raw materials
Raw materials
Preparation Products
N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide maleate Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58