ChemicalBook > CAS DataBase List > PF-06273340

PF-06273340

Product Name: PF-06273340
CAS No.: 1402438-74-7
Chemical Name: PF-06273340
Synonyms: PF6273340;PF-6273340;PF 6273340;PF-06273340;PF-06273340 ，S8407;PF-06273340 >=98% (HPLC);PF-06273340, 10 mM in DMSO;BPIWZDNVMQQBQX-UHFFFAOYSA-N;inhibit,Trk Receptor,PF-06273340,PF06273340,Tropomyosin related kinase receptor,Inhibitor;N-[5-[[2-Amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl]-3-pyridinyl]-5-chloro-2-pyridineacetamide
CBNumber: CB93165808
Molecular Formula: C23H22ClN7O3
Formula Weight: 479.92
MOL File: 1402438-74-7.mol

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PF-06273340 Property

Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 12.40±0.70(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0254
Product name: PF-06273340
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $121
Updated: 2025/07/31

Sigma-Aldrich

Product number: PZ0254
Product name: PF-06273340
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $462
Updated: 2024/03/01

Tocris

Product number: 6115
Product name: PF06273340
Purity: ≥98%(HPLC)
Packaging: 10
Price: $185
Updated: 2021/12/16

TRC

Product number: P294135
Product name: PF06273340
Packaging: 1mg
Price: $55
Updated: 2021/12/16

DC Chemicals

Product number: DC10631
Product name: PF-06273340
Purity: >98%
Packaging: 100mg
Price: $500
Updated: 2021/12/16

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PF-06273340 Chemical Properties,Usage,Production

Uses

PF-06273340 is a potent, selective, orally bioavailable and peripherally restricted pan Trk inhibitor[1].

Biological Activity

PF-06273340 is a brain penetrant, orally available and potent tropomyosin-related kinase (Trk) inhibitor. PF-06273340 is under development as a remedy acute and chronic pain.

IC 50

TRK

storage

Store at RT

References

[1] Skerratt SE, et al. The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain. DOI:10.1021/acs.jmedchem.6b00850

PF-06273340 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-06273340 Suppliers

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1402438-74-7, PF-06273340Related Search:

PF-06273340

N-[5-[2-AMINO-7-(1-HYDROXY-2-METHYLPROPAN-2-YL)PYRROLO[2,3-D]PYRIMIDINE-5-CARBONYL]PYRIDIN-3-YL]-2-(5-CHLOROPYRIDIN-2-YL)ACETAMIDE

BPIWZDNVMQQBQX-UHFFFAOYSA-N

N-[5-[[2-Amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl]-3-pyridinyl]-5-chloro-2-pyridineacetamide

N-(5-(2-amino-7-(1-hydroxy-2-methylpropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)-2-(5-chloropyridin-2-yl)acetamide

2-Pyridineacetamide, N-[5-[[2-amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl]-3-pyridinyl]-5-chloro-

PF-06273340 >=98% (HPLC)

PF 6273340

PF6273340

PF-6273340

inhibit,Trk Receptor,PF-06273340,PF06273340,Tropomyosin related kinase receptor,Inhibitor

PF-06273340, 10 mM in DMSO

PF-06273340 ，S8407

1402438-74-7