ChemicalBook > CAS DataBase List > C 87
C 87
- Product Name
- C 87
- CAS No.
- 332420-90-3
- Chemical Name
- C 87
- Synonyms
- C 87;C87; C-87;TNFalpha-IN-C87;C 87, 10 mM in DMSO;TNF-TNFR Interaction Modulator, C87;TNF Receptor,inhibit,Tumor Necrosis Factor Receptor,C 87,C87,Inhibitor,C-87,TNFR;3-Phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(4-chloro-3-nitrophenyl)hydrazone];1H-Pyrazole-4,5-dione, 3-phenyl-1-(4-phenyl-2-thiazolyl)-, 4-[2-(4-chloro-3-nitrophenyl)hydrazone]
- CBNumber
- CB93167600
- Molecular Formula
- C24H15ClN6O3S
- Formula Weight
- 502.93
- MOL File
- 332420-90-3.mol
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C 87 Property
- Boiling point:
- 667.5±65.0 °C(Predicted)
- Density
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 9.33 mg/mL (18.55 mM);Water : < 0.1 mg/mL (insoluble)
- form
- Solid
- pka
- 5.95±0.40(Predicted)
- color
- Yellow to orange
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Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 5.30796
- Product name
- TNF-TNFR Interaction Modulator, C87
- Packaging
- 10 mg
- Price
- $238
- Updated
- 2026/03/19
Tocris
- Product number
- 5484
- Product name
- C87
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $169
- Updated
- 2021/12/16
Tocris
- Product number
- 5484
- Product name
- C87
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $711
- Updated
- 2021/12/16
TRC
- Product number
- P321295
- Product name
- 3-Phenyl-1-(4-phenyl-2-thiazolyl)-4-[(4-chloro-3-nitrophenyl)hydrazone]-1H-pyrazole-4,5-dione
- Packaging
- 50mg
- Price
- $450
- Updated
- 2021/12/16
TRC
- Product number
- P321295
- Product name
- 3-Phenyl-1-(4-phenyl-2-thiazolyl)-4-[(4-chloro-3-nitrophenyl)hydrazone]-1H-pyrazole-4,5-dione
- Packaging
- 100mg
- Price
- $800
- Updated
- 2021/12/16
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C 87 Chemical Properties,Usage,Production
Uses
3-Phenyl-1-(4-phenyl-2-thiazolyl)-4-[(4-chloro-3-nitrophenyl)hydrazone]-1H-pyrazole-4,5-dione is a TNF alpha inhibitor. It also weakens inflammation and increases survival in a mouse hepatitis model.
Biological Activity
Cell permeable: yes', 'Primary Target
TNFα', 'Reversible: yes', 'Target Ki: 110 nM for hTNF&alpha
in vivo
C 87 (C87) attenuates TNFα-induced inflammation, thereby markedly reducing injuries to the liver and improving animal survival. C 87 injection delays the incidence of death and increases the survival rate by two folds compared with the vehicle control. The level of alanine transaminase and aspartate transaminase is consistently reduced in mice with C 87 treatment[1].
storage
Store at +4°C
C 87 Preparation Products And Raw materials
Raw materials
Preparation Products
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