LGD-6972

Product Name: LGD-6972
CAS No.: 1207989-09-0
Chemical Name: LGD-6972
Synonyms: LGD-6972;LGD6972; LGD 6972;LGD 6972,LGD-6972,LGD6972,Inhibitor,hyperglycaemia,GCGR,Diabetes,cAMP,glucagon,inhibit,Glucagon Receptor;(R)-2-(4-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-4-yl)-3-oxo-3-((2',4',6'-trimethyl-[1,1'-biphenyl]-4-yl)amino)propyl)benzamido)ethane-1-sulfonic acid;2-({4-[(2R)-2-{4'-tert-butyl-[1,1'-biphenyl]-4-yl}-2-({2',4',6'-trimethyl-[1,1'-biphenyl]-4-yl}carbamoyl)ethyl]phenyl}formamido)ethane-1-sulfonic acid;Ethanesulfonic acid, 2-[[4-[(2R)-2-[4'-(1,1-dimethylethyl)[1,1'-biphenyl]-4-yl]-3-oxo-3-[(2',4',6'-trimethyl[1,1'-biphenyl]-4-yl)amino]propyl]benzoyl]amino]-
CBNumber: CB93171696
Molecular Formula: C43H46N2O5S
Formula Weight: 702.9
MOL File: 1207989-09-0.mol

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LGD-6972 Property

Density: 1.206±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:125.0(Max Conc. mg/mL);177.83(Max Conc. mM)
form: Solid
pka: 1.36±0.50(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6449
Product name: LGD-6972
Purity: >98.0%
Packaging: 1mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-6449
Product name: LGD-6972
Purity: >98.0%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-6449
Product name: LGD-6972
Purity: >98.0%
Packaging: 10mg
Price: $660
Updated: 2021/12/16

ChemScene

Product number: CS-6449
Product name: LGD-6972
Purity: >98.0%
Packaging: 50mg
Price: $2220
Updated: 2021/12/16

ChemScene

Product number: CS-6449
Product name: LGD-6972
Purity: >98.0%
Packaging: 100mg
Price: $3300
Updated: 2021/12/16

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LGD-6972 Chemical Properties,Usage,Production

Uses

LGD-6972 is a selective and orally active glucagon receptor antagonist. LGD-6972 has the potential for type 2 diabetes research[1].

in vivo

In vivo, LGD-6972 reduces acute glucagon-stimulated hyperglycaemia as well as the hyperglycaemia observed in diabetic mouse models. The pharmacological activity of LGD-6972 appears to be mediated primarily by inhibiting glucagon receptor signaling^[1].

References

[1] Vajda EG, et al. Pharmacokinetics and pharmacodynamics of single and multiple doses of the glucagon receptor antagonist LGD-6972 in healthy subjects and subjects with type 2 diabetes mellitus. Diabetes Obes Metab. 2017 Jan;19(1):24-32. DOI:10.1111/dom.12752

LGD-6972 Preparation Products And Raw materials

Raw materials

Preparation Products

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LGD-6972 Suppliers

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1207989-09-0, LGD-6972Related Search:

LGD6972; LGD 6972

LGD-6972

Ethanesulfonic acid, 2-[[4-[(2R)-2-[4'-(1,1-dimethylethyl)[1,1'-biphenyl]-4-yl]-3-oxo-3-[(2',4',6'-trimethyl[1,1'-biphenyl]-4-yl)amino]propyl]benzoyl]amino]-

LGD 6972,LGD-6972,LGD6972,Inhibitor,hyperglycaemia,GCGR,Diabetes,cAMP,glucagon,inhibit,Glucagon Receptor

2-({4-[(2R)-2-{4'-tert-butyl-[1,1'-biphenyl]-4-yl}-2-({2',4',6'-trimethyl-[1,1'-biphenyl]-4-yl}carbamoyl)ethyl]phenyl}formamido)ethane-1-sulfonic acid

(R)-2-(4-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-4-yl)-3-oxo-3-((2',4',6'-trimethyl-[1,1'-biphenyl]-4-yl)amino)propyl)benzamido)ethane-1-sulfonic acid

1207989-09-0

C43H46N2O5S