STK16-IN-1

Product Name: STK16-IN-1
CAS No.: 1223001-53-3
Chemical Name: STK16-IN-1
Synonyms: STK16-IN-1;STK16 inhibitor 1;STK16-IN-1 >=98% (HPLC);STK16-IN-1, 10 mM in DMSO;STK16IN1,STK-16-IN-1,Inhibitor,STK16 IN 1,inhibit;1-(4-fluoro-3-methylphenyl)-1H-pyrrolo[2,3-h][1,6]naphthyridin-2(7H)-one;1-(4-Fluoro-3-methylphenyl)-1,7-dihydro-2H-pyrrolo[2,3-h]-1,6-naphthyridin-2-one;2H-Pyrrolo[2,3-h]-1,6-naphthyridin-2-one, 1-(4-fluoro-3-methylphenyl)-1,7-dihydro-
CBNumber: CB93171702
Molecular Formula: C17H12FN3O
Formula Weight: 293.3
MOL File: 1223001-53-3.mol

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STK16-IN-1 Property

Boiling point:: 582.3±50.0 °C(Predicted)
Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble
form: powder
pka: 10.85±0.20(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1728
Product name: STK16-IN-1
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $114
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1728
Product name: STK16-IN-1
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $386
Updated: 2022/05/15

Cayman Chemical

Product number: 27370
Product name: STK16-IN-1
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 27370
Product name: STK16-IN-1
Packaging: 50mg
Price: $672
Updated: 2024/03/01

Cayman Chemical

Product number: 27370
Product name: STK16-IN-1
Packaging: 10mg
Price: $175
Updated: 2024/03/01

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STK16-IN-1 Chemical Properties,Usage,Production

Uses

STK16-IN-1 is a highly selective STK16 kinase inhibitor.

Biological Activity

STK16-IN-1 is a cell-permeable pyrrolonaphthyridinone compound th at acts as an ATP-competitive inhibitor against NAK (Numb Associated Kinase) family serine/threonine kinase STK16 (IC50/substrate = 0.91 μM/4EBP1 and 1.2 μM/DRG1, [ATP] = 20 μM) with excellent selectivity over a panel of 378 kinases. Despite its inhibitory potency against PI 3-Ks (IC50 = 1.07, 0.856, 0.867 μM against p110α/p85α, p110δ/p85α, p110γ , respectively) in cell-free assays, STK16-IN-1 is ineffective against their cellular activity up to 10 μM concentration. STK16-IN-1 treatment (10 μM for 72 hrs) is shown to cause cell number reduction (~50% in HCT-116 and MCF-7 cultures), as well as increased populations of binucleated cells (~5-fold in MCF-7 culture) and G2/M cells (~7 and 3-fold in HCT-116 and MCF-7 cultures, respectively) in an STK16-dependent manner. A useful tool for elucidating STK16 biological functions.

STK16-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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STK16-IN-1 Suppliers

China 52 United Kingdom 1 United States 8 Global 61

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1223001-53-3, STK16-IN-1Related Search:

STF 083010

STK16-IN-1

STK16 inhibitor 1

1-(4-Fluoro-3-methylphenyl)-1,7-dihydro-2H-pyrrolo[2,3-h]-1,6-naphthyridin-2-one

1-(4-fluoro-3-methylphenyl)-1H-pyrrolo[2,3-h][1,6]naphthyridin-2(7H)-one

2H-Pyrrolo[2,3-h]-1,6-naphthyridin-2-one, 1-(4-fluoro-3-methylphenyl)-1,7-dihydro-

STK16-IN-1 >=98% (HPLC)

STK16IN1,STK-16-IN-1,Inhibitor,STK16 IN 1,inhibit

STK16-IN-1, 10 mM in DMSO

1223001-53-3