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INF39

Product Name
INF39
CAS No.
866028-26-4
Chemical Name
INF39
Synonyms
INF39;CS-2508;INF39 >=98% (HPLC);INF-39;INF 39;INF39;Ethyl 2-(2-chlorobenzyl)acrylate;Benzenepropanoic acid, 2-chloro-α-methylene-, ethyl ester;inhibit,INF 39,INF39,INF-39,NOD-like Receptor (NLR),Inhibitor
CBNumber
CB93175821
Molecular Formula
C12H13ClO2
Formula Weight
224.68
MOL File
866028-26-4.mol
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INF39 Property

Boiling point:
309.3±30.0 °C(Predicted)
Density 
1.131±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO:66.0(Max Conc. mg/mL);293.75(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);133.52(Max Conc. mM)
form 
oil
color 
colorless to light brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2239
Product name
INF39
Purity
≥98% (HPLC)
Packaging
5mg
Price
$128
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2239
Product name
INF39
Purity
≥98% (HPLC)
Packaging
25mg
Price
$411
Updated
2024/03/01
Cayman Chemical
Product number
28476
Product name
INF39
Packaging
5mg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
28476
Product name
INF39
Packaging
25mg
Price
$463
Updated
2024/03/01
Cayman Chemical
Product number
28476
Product name
INF39
Packaging
10mg
Price
$210
Updated
2024/03/01
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INF39 Chemical Properties,Usage,Production

Uses

INF 39 is a NLRP3 inflammasome inhibitor. Used in the treatment of inflammatory bowel disease.

Biochem/physiol Actions

INF39 is an orally active acrylate derivative and a non-cytotoxic INF4E analog (no toxicity at 100 μM in THP-1 cultures vs. TC50 = 65 μM with INF4E) that acts as an irreversible inhibitor against NLRP3 (NACHT, LRR and PYD domains-containing protein 3) ATPase activity (52% inhibition in 15 min by 100 μM INF39; 105 ng human NLP3 & 250 μM ATP) essential for the NLRP3 inflammasome assembly and activation. INF39 effectively decreases 5 mM (30 min) ATP-induced interleukin-1β (IL-1β) release and pyroptosis of murine bone marrow-derived macrophages in cultures (by 55-58% and 43-65%, respectively, with 1-hr 10 μM INF39 pretreatment of LPS-primed BMDM) and alleviates gut-associated inflammation in a rat model of 2,4-dinitrobenzenesulfonic acid (DNBS)-induced colitis in vivo (12.5-50 mg/kg/day in 0.2 mL olive oil p.o.).

storage

Store at -20°C

INF39 Preparation Products And Raw materials

Raw materials

Preparation Products

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INF39 Suppliers

China 44 India 1 United Kingdom 1 United States 7 Global 53
Shanghai Boyle Chemical Co., Ltd.
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View Lastest Price from INF39 manufacturers

Career Henan Chemica Co
Product
INF39 866028-26-4
Price
US $1.00/g
Min. Order
1g
Purity
85.0-99.8%
Supply Ability
20 tons
Release date
2020-11-12

866028-26-4, INF39Related Search:


  • INF39
  • Ethyl 2-(2-chlorobenzyl)acrylate
  • CS-2508
  • INF-39;INF 39;INF39
  • Benzenepropanoic acid, 2-chloro-α-methylene-, ethyl ester
  • INF39 >=98% (HPLC)
  • inhibit,INF 39,INF39,INF-39,NOD-like Receptor (NLR),Inhibitor
  • 866028-26-4