ChemicalBook > CAS DataBase List > INF39

INF39

Product Name: INF39
CAS No.: 866028-26-4
Chemical Name: INF39
Synonyms: INF39;CS-2508;INF39 ，S8559;INF39 >=98% (HPLC);INF-39;INF 39;INF39;INF39, 10 mM in DMSO;Ethyl 2-(2-chlorobenzyl)acrylate;Benzenepropanoic acid, 2-chloro-α-methylene-, ethyl ester;inhibit,INF 39,INF39,INF-39,NOD-like Receptor (NLR),Inhibitor
CBNumber: CB93175821
Molecular Formula: C12H13ClO2
Formula Weight: 224.68
MOL File: 866028-26-4.mol

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INF39 Property

Boiling point:: 309.3±30.0 °C(Predicted)
Density: 1.131±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO:66.0(Max Conc. mg/mL);293.75(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);133.52(Max Conc. mM)
form: oil
color: colorless to light brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2239
Product name: INF39
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $106.18
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2239
Product name: INF39
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $360
Updated: 2025/07/31

Cayman Chemical

Product number: 28476
Product name: INF39
Packaging: 5mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 28476
Product name: INF39
Packaging: 25mg
Price: $463
Updated: 2024/03/01

Cayman Chemical

Product number: 28476
Product name: INF39
Packaging: 10mg
Price: $210
Updated: 2024/03/01

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INF39 Chemical Properties,Usage,Production

Uses

INF 39 is a NLRP3 inflammasome inhibitor. Used in the treatment of inflammatory bowel disease.

Biochem/physiol Actions

INF39 is an orally active acrylate derivative and a non-cytotoxic INF4E analog (no toxicity at 100 μM in THP-1 cultures vs. TC50 = 65 μM with INF4E) that acts as an irreversible inhibitor against NLRP3 (NACHT, LRR and PYD domains-containing protein 3) ATPase activity (52% inhibition in 15 min by 100 μM INF39; 105 ng human NLP3 & 250 μM ATP) essential for the NLRP3 inflammasome assembly and activation. INF39 effectively decreases 5 mM (30 min) ATP-induced interleukin-1β (IL-1β) release and pyroptosis of murine bone marrow-derived macrophages in cultures (by 55-58% and 43-65%, respectively, with 1-hr 10 μM INF39 pretreatment of LPS-primed BMDM) and alleviates gut-associated inflammation in a rat model of 2,4-dinitrobenzenesulfonic acid (DNBS)-induced colitis in vivo (12.5-50 mg/kg/day in 0.2 mL olive oil p.o.).

in vivo

Oral administration of INF39 reduces systemic and colonic inflammation in rats treated with 2,4- dinitrobenzenesulfonic acid. Significant increments of body weight are observed in inflamed rats under treatment with INF39 (12.5, 25, and 50 mg/ kg). Treatment with DNBS results in a significant increment of spleen weight (+39.3%). Such an increase is significantly reduced by administration of INF39 (+2.2, +4.3 and +4.8% at 12.5, 25, 50 mg/kg, respectively). The inhibition of NLRP3 inflammasome complex with INF39 dose-dependently attenuates the decrease in colonic length ( 19, 13 and 8% at 12.5, 25, 50 mg/kg, respectively). Rats treated with INF39 displays a significant reduction of macroscopic damage score (4.7 at 12.5 mg/kg, 3.1 at 25 mg/kg, and 2.8 at 50 mg/kg). Oral administration of INF39 reduces colonic myeloperoxidase, IL-1β, and TNF Levels in DNBS-treated rats^[1].

IC 50

NLRP3

storage

Store at -20°C

INF39 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from INF39 manufacturers

Career Henan Chemica Co

Product: INF39 866028-26-4
Price: US $1.00/g
Min. Order: 1g
Purity: 85.0-99.8%
Supply Ability: 20 tons
Release date: 2020-11-12

866028-26-4, INF39Related Search:

INF39

Ethyl 2-(2-chlorobenzyl)acrylate

CS-2508

INF-39;INF 39;INF39

Benzenepropanoic acid, 2-chloro-α-methylene-, ethyl ester

INF39 >=98% (HPLC)

inhibit,INF 39,INF39,INF-39,NOD-like Receptor (NLR),Inhibitor

INF39, 10 mM in DMSO

INF39 ，S8559

866028-26-4