DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE

Product Name: DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE
CAS No.: 64005-90-9
Chemical Name: DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE
Synonyms: PIB;PiB >=98% (HPLC);WNKQGFNIIHNGQM-UHFFFAOYSA-N;PPIase-Parvulin Inhibitor - CAS 64005-90-9 - Calbiochem;DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE;PPIase-Parvulin inhibitor,Inhibitor,PPIase Parvulin Inhibitor,PPIaseParvulin Inhibitor,inhibit;diethyl 2,2'-(1,3,6,8-tetraoxo-1,3,6,8-tetrahydrobenzo[lmn][3,8]phenanthroline-2,7-diyl)diacetate;Benzo[lmn][3,8]phenanthroline-2,7-diacetic acid, 1,3,6,8-tetrahydro-1,3,6,8-tetraoxo-, 2,7-diethyl ester
CBNumber: CB9321371
Molecular Formula: C22H18N2O8
Formula Weight: 438.39
MOL File: Mol file

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DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE Property

storage temp.: 2-8°C
solubility: DMSO: soluble1-2mg/mL (warmed)
form: Brownish solid
color: white to light brown
InChI: InChI=1S/C18H18N2O8/c1-3-23-15(21)9-19-25-11-5-7-13-18-14(8-6-12(26-19)17(11)18)28-20(27-13)10-16(22)24-4-2/h5-8H,3-4,9-10H2,1-2H3
InChIKey: RUZSTTGSEVILES-UHFFFAOYSA-N
SMILES: C12=CC=C3C4C1=C(C=CC=4ON(CC(OCC)=O)O3)ON(CC(OCC)=O)O2

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Safety

Hazard Codes: N
Risk Statements: 50
Safety Statements: 61
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B7688
Product name: PiB
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $103
Updated: 2025/07/31

Cayman Chemical

Product number: 17214
Product name: PPIase-Parvulin Inhibitor
Purity: ≥95%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 17214
Product name: PPIase-Parvulin Inhibitor
Purity: ≥95%
Packaging: 5mg
Price: $120
Updated: 2024/03/01

Sigma-Aldrich

Product number: B7688
Product name: PiB
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $332
Updated: 2025/07/31

Cayman Chemical

Product number: 17214
Product name: PPIase-Parvulin Inhibitor
Purity: ≥95%
Packaging: 10mg
Price: $211
Updated: 2024/03/01

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DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE Chemical Properties,Usage,Production

Uses

PPIase-Parvulin inhibitor (compound B) is a cell-permeable inhibitor targeting PPIase Pin1 and Par14, with IC50s of 1.5 and 1.0 μM, respectively. PPIase-Parvulin inhibitor has anticancer activity and inhibits the growth and proliferation of mouse embryonic fibroblasts (MEFs)[1].

Biological Activity

PiB is an inhibitor of the peptidylprolyl isomerase Pin-1. Inhibition of Pin-1 leads to destabilization of the transcription factor Nanog, which is required for maintenance of embryonic stem cell cultures.

References

[1] Uchida T, et al. Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. Chem Biol. 2003 Jan;10(1):15-24. DOI:10.1016/s1074-5521(02)00310-1

DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

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DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE Suppliers

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64005-90-9, DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATERelated Search:

PIB

DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE

WNKQGFNIIHNGQM-UHFFFAOYSA-N

PPIase-Parvulin Inhibitor - CAS 64005-90-9 - Calbiochem

Benzo[lmn][3,8]phenanthroline-2,7-diacetic acid, 1,3,6,8-tetrahydro-1,3,6,8-tetraoxo-, 2,7-diethyl ester

PiB >=98% (HPLC)

PPIase-Parvulin inhibitor,Inhibitor,PPIase Parvulin Inhibitor,PPIaseParvulin Inhibitor,inhibit

diethyl 2,2'-(1,3,6,8-tetraoxo-1,3,6,8-tetrahydrobenzo[lmn][3,8]phenanthroline-2,7-diyl)diacetate

64005-90-9

C22H18N2O8