Azadibenzocyclooctyne-CONH-N-hydroxysuccinimidyl ester

Product Name: Azadibenzocyclooctyne-CONH-N-hydroxysuccinimidyl ester
CAS No.: 1435934-53-4
Chemical Name: Azadibenzocyclooctyne-CONH-N-hydroxysuccinimidyl ester
Synonyms: DBCO-CONH-S-S-NHS ester;DBCO-CONH-S-S-COONHS ester;DBCO-S-S-SE,DBCO-S-S-NHS,DBCO-S-S-succinimidyl ester;Azadibenzocyclooctyne-CONH-N-hydroxysuccinimidyl ester;DBCO-S-S-NHS ester,DBCO-S-S-SE,DBCO-S-S-succinimidyl ester;Propanoic acid, 3-[[2-[[4-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-1,4-dioxobutyl]amino]ethyl]dithio]-, 2,5-dioxo-1-pyrrolidinyl ester
CBNumber: CB93309381
Molecular Formula: C28H27N3O6S2
Formula Weight: 565.66
MOL File: 1435934-53-4.mol

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Azadibenzocyclooctyne-CONH-N-hydroxysuccinimidyl ester Property

form: Solid
color: White to light yellow
InChIKey: RPNGUSKTYYIUDE-UHFFFAOYSA-N
SMILES: C(ON1C(=O)CCC1=O)(=O)CCSSCCNC(=O)CCC(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0119016
Product name: DBCO-CONH-S-S-NHSester
Purity: 95.04%
Packaging: 25mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0119016
Product name: DBCO-CONH-S-S-NHSester
Purity: 95.04%
Packaging: 50mg
Price: $950
Updated: 2021/12/16

ChemScene

Product number: CS-0119016
Product name: DBCO-CONH-S-S-NHSester
Purity: 95.04%
Packaging: 100mg
Price: $1350
Updated: 2021/12/16

purepeg

Product number: 2884802
Product name: Azadibenzocyclooctyne-CONH-N-hydroxysuccinimidylester
Purity: min.95%
Packaging: 25mg
Price: $195
Updated: 2021/12/16

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Azadibenzocyclooctyne-CONH-N-hydroxysuccinimidyl ester Chemical Properties,Usage,Production

Uses

DBCO-CONH-S-S-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-CONH-S-S-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Biological Activity

DBCO-CONH-S-S-NHS ester is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

IC 50

Disulfide Cleavable Linker; Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

Azadibenzocyclooctyne-CONH-N-hydroxysuccinimidyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Azadibenzocyclooctyne-CONH-N-hydroxysuccinimidyl ester manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: DBCO-CONH-S-S-NHS ester 1435934-53-4
Price: US $0.00/mg
Min. Order: 25mg
Purity: >98.00%
Supply Ability: 100
Release date: 2024-03-20

1435934-53-4, Azadibenzocyclooctyne-CONH-N-hydroxysuccinimidyl esterRelated Search:

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Azadibenzocyclooctyne-CONH-N-hydroxysuccinimidyl ester

DBCO-CONH-S-S-COONHS ester

DBCO-S-S-NHS ester,DBCO-S-S-SE,DBCO-S-S-succinimidyl ester

DBCO-CONH-S-S-NHS ester

Propanoic acid, 3-[[2-[[4-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-1,4-dioxobutyl]amino]ethyl]dithio]-, 2,5-dioxo-1-pyrrolidinyl ester

DBCO-S-S-SE,DBCO-S-S-NHS,DBCO-S-S-succinimidyl ester

1435934-53-4

C28H27N3O6S2

ADC LINKER

DBCO