UK-371804 hydrochloride

Product Name: UK-371804 hydrochloride
CAS No.: 256476-36-5
Chemical Name: UK-371804 hydrochloride
Synonyms: UK-371804 HCl;UK-371804 hydrochloride;UK371804 HCl,UK 371804 HCl;UK-371,804 HCl >=98% (HPLC);2-((4-Chloro-1-guanidinoisoquinoline)-7-sulfonamido)-2-methylpropanoic acid hydrochloride
CBNumber: CB93313256
Molecular Formula: C14H17Cl2N5O4S
Formula Weight: 422.28
MOL File: 256476-36-5.mol

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UK-371804 hydrochloride Property

Melting point:: 258 °C (decomp)
storage temp.: -20°C
solubility: DMSO: 42 mg/mL (99.46 mM);Ethanol: Insoluble
form: powder
color: white to beige
Water Solubility: Water: Insoluble
InChI: 1S/C14H16ClN5O4S.ClH/c1-14(2,12(21)22)20-25(23,24)7-3-4-8-9(5-7)11(19-13(16)17)18-6-10(8)15;/h3-6,20H,1-2H3,(H,21,22)(H4,16,17,18,19);1H
InChIKey: IUBFETAFRGVODB-UHFFFAOYSA-N
SMILES: CC(C)(NS(=O)(C1=CC2=C(C=C1)C(Cl)=CN=C2NC(N)=N)=O)C(O)=O.[H]Cl

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0344
Product name: UK-371,804 HCl
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $105
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0344
Product name: UK-371,804 HCl
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $338
Updated: 2024/03/01

AK Scientific

Product number: 8759CW
Product name: UK-371,804 HCl
Packaging: 5mg
Price: $127
Updated: 2021/12/16

AK Scientific

Product number: 8759CW
Product name: UK-371,804 HCl
Packaging: 25mg
Price: $266
Updated: 2021/12/16

Ambeed

Product number: A109441
Product name: UK-371,804 HCl
Purity: 99+%
Packaging: 5mg
Price: $51
Updated: 2021/12/16

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UK-371804 hydrochloride Chemical Properties,Usage,Production

Uses

UK-371804 hydrochloride (compound 24) is a urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 10 nM[1].

Biochem/physiol Actions

UK-371,804 is a reversible, substrate-competitive, highly potent (Ki = 10 nM) and selective urokinase-type plasminogen activator (uPA) Inhibitor with excellent selectivity over tPA, plasmin, Factor IXa and Xa. When applied topically, UK-371,80 effectively penetrates into excisional wounds of experimental pigs with no adverse effect on wound closure. UK-371,804 effectively blocks EGR-FMK from binding human uPA even in the presence of tissue proteins.

References

[1] Paul V Fish, et al. Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. J Med Chem. 2007, 50, 10. DOI:10.1021/jm061066t

UK-371804 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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UK-371804 hydrochloride Suppliers

China 27 India 1 United States 4 Global 32

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256476-36-5, UK-371804 hydrochlorideRelated Search:

UK-371804 hydrochloride

UK-371804 HCl

UK-371,804 HCl >=98% (HPLC)

2-((4-Chloro-1-guanidinoisoquinoline)-7-sulfonamido)-2-methylpropanoic acid hydrochloride

UK371804 HCl,UK 371804 HCl

256476-36-5