ChemicalBook > CAS DataBase List > MRT-83 hydrochloride
MRT-83 hydrochloride
- Product Name
- MRT-83 hydrochloride
- CAS No.
- 1359944-60-7
- Chemical Name
- MRT-83 hydrochloride
- Synonyms
- MRT-83 HCl salt;MRT-83 hydrochloride
- CBNumber
- CB93313504
- Molecular Formula
- C31H31ClN4O5
- Formula Weight
- 575.06
- MOL File
- 1359944-60-7.mol
More
Less
MRT-83 hydrochloride Property
- storage temp.
- 4°C, away from moisture
- solubility
- DMSO : 250 mg/mL (434.74 mM; Need ultrasonic)
- form
- Solid
- color
- White to off-white
More
Less
MRT-83 hydrochloride Chemical Properties,Usage,Production
Biological Activity
MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease[1]. MRT-83 (hydrochloride) (compound 86) has IC50s of 15 and 11 nM respectively in Shh-light2 and C3H10T1/2 cells in the biological activity assay[1].
References
[1]. Solinas A, et al. Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J Med Chem. 2012;55(4):1559-1571.
MRT-83 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
MRT-83 hydrochloride Suppliers
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9804
- Advantage
- 58
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29764
- Advantage
- 68
- Tel
- 0519-85524369
- 3477467573@qq.com
- Country
- China
- ProdList
- 8617
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24641
- Advantage
- 58
- Tel
- support@targetmol.com
- Country
- United States
- ProdList
- 38630
- Advantage
- 58