MRT-83 hydrochloride

Product Name: MRT-83 hydrochloride
CAS No.: 1359944-60-7
Chemical Name: MRT-83 hydrochloride
Synonyms: MRT-83 HCl salt;MRT-83 hydrochloride
CBNumber: CB93313504
Molecular Formula: C31H31ClN4O5
Formula Weight: 575.06
MOL File: 1359944-60-7.mol

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MRT-83 hydrochloride Property

storage temp.: 4°C, away from moisture
solubility: DMSO : 250 mg/mL (434.74 mM; Need ultrasonic)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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MRT-83 hydrochloride Chemical Properties,Usage,Production

Uses

MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease[1].

Biological Activity

MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease[1]. MRT-83 (hydrochloride) (compound 86) has IC50s of 15 and 11 nM respectively in Shh-light2 and C3H10T1/2 cells in the biological activity assay[1].

References

[1]. Solinas A, et al. Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J Med Chem. 2012;55(4):1559-1571.

MRT-83 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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MRT-83 hydrochloride Suppliers

China 5 United States 1 Global 6

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
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Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
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Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29759
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TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354;
Email: support@targetmol.com
Country: United States
ProdList: 39035
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Guangzhou Zhuosheng Biotechnology Co., Ltd.

Tel: 13249155203
Country: CHINA
ProdList: 107
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MRT-83 hydrochloride

MRT-83 HCl salt

1359944-60-7