3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL

Product Name: 3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL
CAS No.: 57717-80-3
Chemical Name: 3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL
Synonyms: CGP 7930;3-(3',5'-DI-TERT-BUTYL-4'-HYDROXY)PHENYL-2,2-DIMETHYLPROPANOL;3,5-bis(1,1-Dimethylethyl)-4-hydroxy-β,β-dimethyl-benzenepropanol;3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL;Benzenepropanol, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-β,β-dimethyl-;3,5-Bis(1,1-dimethylethyl)-4-hydroxy-beta,beta-dimethylbenzenepropanol
CBNumber: CB9331718
Molecular Formula: C19H32O2
Formula Weight: 292.46
MOL File: 57717-80-3.mol

More

Less

3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL Property

storage temp.: Desiccate at RT
solubility: DMSO: 22 mg/mL, soluble
form: solid
color: white

More

Less

Safety

WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 29429
Product name: CGP 7930
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 29429
Product name: CGP 7930
Packaging: 5mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 29429
Product name: CGP 7930
Packaging: 10mg
Price: $172
Updated: 2024/03/01

Tocris

Product number: 1513
Product name: CGP7930
Purity: ≥98%(HPLC)
Packaging: 10
Price: $159
Updated: 2021/12/16

Tocris

Product number: 1513
Product name: CGP7930
Purity: ≥98%(HPLC)
Packaging: 50
Price: $658
Updated: 2021/12/16

More

Less

3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL Chemical Properties,Usage,Production

Description

CGP 7930 is a positive allosteric modulator of GABA_B receptors. It enhances GABA binding with a maximal effect of 143% compared to a GABA-only control in CHO cells membranes expressing the GABA_B(1b/2) receptor and enhances GABA binding to rat cortical membranes when used at a concentration of 30 μM. It is selective for GABA binding to heterodimeric GABA_B(1b/2) over monomeric GABA_B(1b) receptors. CGP 7930 potentiates the efficacy of the GABA_B receptor agonist baclofen in decreasing the spontaneous firing rate of dopaminergic neurons in the rat ventral tegmental area (VTA) in vitro (EC₅₀ = 0.27 μM). It also potentiates the sedative-reducing effects induced by the GABA_B receptor agonists baclofen and γ-hydroxybutyric acid (GHB) in rats when administered at doses ranging from 10 to 170 mg/kg, effects that can be blocked by the GABA_B receptor antagonist SCH 50911. CGP 7930 reduces self-administration of nicotine, alcohol, and cocaine in rodent models. It suppresses the acquisition of alcohol drinking behavior in alcohol-naïve Sardinian alcohol-preferring rats over a five-day period when administered at doses ranging from 25 to 100 mg/kg and transiently reduces the maintenance of alcohol drinking behavior in alcohol-experienced rats at a dose of 100 mg/kg.

Definition

ChEBI: 2,6-ditert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol is an alkylbenzene.

Biological Activity

Positive allosteric modulator of GABA B receptors. Increases the potency and efficacy of GABA at both native and recombinant GABA B receptors (EC 50 values are 5.37 and 4.60 μ M respectively) and enhances the inhibitory effect of the agonist L-baclofen in cultured cortical neurons. Reduces operant self-administration of ethanol in alcohol-preferring rats following i.p. administration.

storage

Desiccate at RT

3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL Suppliers

CHINA 28 Germany 2 Switzerland 1 United Kingdom 1 United States 7 Global 39

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Changzhou Furuisi Biotechnology Co., Ltd

Tel: 0519-85524369
Email: 3477467573@qq.com
Country: China
ProdList: 8617
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 13774214275
Email: zhouzz@univ-bio.com
Country: China
ProdList: 24994
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 4988
Advantage: 58

Nanjing Tengyi Biotechnology Co., Ltd

Tel: 025-58851786 17714337195
Email: sales@tybiochem.com
Country: China
ProdList: 6813
Advantage: 58

57717-80-3, 3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOLRelated Search:

UV-144 2,2-DIMETHYL-3-(3-METHYLPHENYL) PROPANOL 3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL

CGP 7930

3-(3',5'-DI-TERT-BUTYL-4'-HYDROXY)PHENYL-2,2-DIMETHYLPROPANOL

3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL

3,5-Bis(1,1-dimethylethyl)-4-hydroxy-beta,beta-dimethylbenzenepropanol

3,5-bis(1,1-Dimethylethyl)-4-hydroxy-β,β-dimethyl-benzenepropanol

Benzenepropanol, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-β,β-dimethyl-

57717-80-3

GABA/Glycine receptor