3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL

Product Name: 3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL
CAS No.: 57717-80-3
Chemical Name: 3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL
Synonyms: CGP 7930;3-(3',5'-DI-TERT-BUTYL-4'-HYDROXY)PHENYL-2,2-DIMETHYLPROPANOL;3,5-bis(1,1-Dimethylethyl)-4-hydroxy-β,β-dimethyl-benzenepropanol;3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL;Benzenepropanol, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-β,β-dimethyl-;3,5-Bis(1,1-dimethylethyl)-4-hydroxy-beta,beta-dimethylbenzenepropanol
CBNumber: CB9331718
Molecular Formula: C19H32O2
Formula Weight: 292.46
MOL File: 57717-80-3.mol

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3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL Property

storage temp.: Desiccate at RT
solubility: DMSO: 22 mg/mL, soluble
form: solid
color: white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29429
Product name: CGP 7930
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 29429
Product name: CGP 7930
Packaging: 5mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 29429
Product name: CGP 7930
Packaging: 10mg
Price: $172
Updated: 2024/03/01

Tocris

Product number: 1513
Product name: CGP7930
Purity: ≥98%(HPLC)
Packaging: 10
Price: $159
Updated: 2021/12/16

Tocris

Product number: 1513
Product name: CGP7930
Purity: ≥98%(HPLC)
Packaging: 50
Price: $658
Updated: 2021/12/16

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3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL Chemical Properties,Usage,Production

Description

CGP 7930 is a positive allosteric modulator of GABA_B receptors. It enhances GABA binding with a maximal effect of 143% compared to a GABA-only control in CHO cells membranes expressing the GABA_B(1b/2) receptor and enhances GABA binding to rat cortical membranes when used at a concentration of 30 μM. It is selective for GABA binding to heterodimeric GABA_B(1b/2) over monomeric GABA_B(1b) receptors. CGP 7930 potentiates the efficacy of the GABA_B receptor agonist baclofen in decreasing the spontaneous firing rate of dopaminergic neurons in the rat ventral tegmental area (VTA) in vitro (EC₅₀ = 0.27 μM). It also potentiates the sedative-reducing effects induced by the GABA_B receptor agonists baclofen and γ-hydroxybutyric acid (GHB) in rats when administered at doses ranging from 10 to 170 mg/kg, effects that can be blocked by the GABA_B receptor antagonist SCH 50911. CGP 7930 reduces self-administration of nicotine, alcohol, and cocaine in rodent models. It suppresses the acquisition of alcohol drinking behavior in alcohol-naïve Sardinian alcohol-preferring rats over a five-day period when administered at doses ranging from 25 to 100 mg/kg and transiently reduces the maintenance of alcohol drinking behavior in alcohol-experienced rats at a dose of 100 mg/kg.

Definition

ChEBI: 2,6-ditert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol is an alkylbenzene.

Biological Activity

Positive allosteric modulator of GABA B receptors. Increases the potency and efficacy of GABA at both native and recombinant GABA B receptors (EC 50 values are 5.37 and 4.60 μ M respectively) and enhances the inhibitory effect of the agonist L-baclofen in cultured cortical neurons. Reduces operant self-administration of ethanol in alcohol-preferring rats following i.p. administration.

storage

Desiccate at RT

3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL Suppliers

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57717-80-3, 3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOLRelated Search:

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