N-((2R,3S)-2-(4-Chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3

ChemicalBook > CAS DataBase List > N-((2R,3S)-2-(4-Chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3

N-((2R,3S)-2-(4-Chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3

Product Name: N-((2R,3S)-2-(4-Chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3
CAS No.: 1808951-93-0
Chemical Name: N-((2R,3S)-2-(4-Chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3
Synonyms: LP99;LP99, 10 mM in DMSO;N-((2R,3S)-2-(4-Chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3;N-((2R,3S)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3-yl)-2-methylpropane-1-sulfonamide;N-[(2R,3S)-2-(4-Chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-1-propanesulfonamide;1-Propanesulfonamide, N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-;selective,Epigenetic Reader Domain,LP99,organocatalysis,cytokine,LP 99,epigenetics,probe,bromodomain,LP-99,pro-inflammatory,inhibit,Inhibitor,secretion,histones
CBNumber: CB93328926
Molecular Formula: C26H30ClN3O4S
Formula Weight: 516.05
MOL File: 1808951-93-0.mol

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N-((2R,3S)-2-(4-Chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3 Property

Boiling point:: 726.6±70.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2) (1:9): 0.1 mg/ml
form: powder
pka: 9.56±0.40(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17661
Product name: LP99
Purity: ≥98%
Packaging: 500μg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 17661
Product name: LP99
Purity: ≥98%
Packaging: 1mg
Price: $87
Updated: 2024/03/01

Cayman Chemical

Product number: 17661
Product name: LP99
Purity: ≥98%
Packaging: 5mg
Price: $286
Updated: 2024/03/01

Tocris

Product number: 5496
Product name: LP99
Purity: ≥98%(HPLC)
Packaging: 25
Price: $1039
Updated: 2021/12/16

Tocris

Product number: 5496
Product name: LP99
Purity: ≥98%(HPLC)
Packaging: 5
Price: $268
Updated: 2021/12/16

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N-((2R,3S)-2-(4-Chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3 Chemical Properties,Usage,Production

Uses

LP99 is a novel BRD7 and BRD9 specific inhibitor.

Biochem/physiol Actions

LP99 is a potent and selective bromodomain BRD9 and BRD7 inhibitor with a higher potency for BRD9 (Kd = 99 nM) than for BRD7 (Kd = 909 nM), and no inhibition for any of the 48 other BRDs tested. LP99 was shown to disrupt BRD7 and BRD9 binding to chromatin in cells. LP99 also inhibited interleukin 6 (IL-6) secretion, suggesting that BRD7/9 plays a role in the regulation of pro-inflammatory cytokine secretion. LP99 is not cell cytotoxic up to 25 μM. For full characterization details, please visit the LP99 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

storage

Store at -20°C

N-((2R,3S)-2-(4-Chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3 Preparation Products And Raw materials

Raw materials

Preparation Products

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N-((2R,3S)-2-(4-Chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3 Suppliers

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1808951-93-0, N-((2R,3S)-2-(4-Chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3Related Search:

N-((2R,3S)-2-(4-Chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3

LP99

N-[(2R,3S)-2-(4-Chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-1-propanesulfonamide

N-((2R,3S)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3-yl)-2-methylpropane-1-sulfonamide

selective,Epigenetic Reader Domain,LP99,organocatalysis,cytokine,LP 99,epigenetics,probe,bromodomain,LP-99,pro-inflammatory,inhibit,Inhibitor,secretion,histones

1-Propanesulfonamide, N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-

LP99, 10 mM in DMSO

1808951-93-0

C26H30ClN3O4S