ChemicalBook > CAS DataBase List > RN-18

RN-18

Product Name: RN-18
CAS No.: 431980-38-0
Chemical Name: RN-18
Synonyms: RN-18;RN18;RN 18;RN-18, 10 mM in DMSO;N-(2-Methoxyphenyl)-2-((4-nitrophenyl)thio)benzamide;Benzamide, N-(2-methoxyphenyl)-2-[(4-nitrophenyl)thio]-;RN18,RN 18,inhibit,Inhibitor,Human immunodeficiency virus,HIV,RN-18
CBNumber: CB93333616
Molecular Formula: C20H16N2O4S
Formula Weight: 380.42
MOL File: 431980-38-0.mol

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RN-18 Property

Boiling point:: 493.6±40.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml; Ethanol: slightly soluble
form: A crystalline solid
pka: 12.33±0.70(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23331
Product name: RN-18
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 23331
Product name: RN-18
Purity: ≥98%
Packaging: 5mg
Price: $157
Updated: 2024/03/01

Cayman Chemical

Product number: 23331
Product name: RN-18
Purity: ≥98%
Packaging: 10mg
Price: $258
Updated: 2024/03/01

Cayman Chemical

Product number: 23331
Product name: RN-18
Purity: ≥98%
Packaging: 25mg
Price: $551
Updated: 2024/03/01

ChemScene

Product number: CS-6953
Product name: RN-18
Purity: 99.37%
Packaging: 50mg
Price: $648
Updated: 2021/12/16

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RN-18 Chemical Properties,Usage,Production

Uses

RN-18 is a selective inhibitor of?virion infectivity factor (Vif)?APOBEC interactions and HIV-1 replication.

Synthesis

36684-47-6

1849-36-1

431980-38-0

Method A: Synthesis of N-(2-methoxyphenyl)-2-((4-nitrophenyl)thio)benzamide (1) The synthesis of target compound 1 was carried out according to the method described in Scheme 9.The key step of the reaction was the reaction of 2-iodo-N-(2-methoxyphenyl)benzamide 3 with 4-nitrophenylthiophenol 4 via a copper-catalyzed coupling reaction under microwave radiation. First, intermediate compound 3 was prepared in high yield by the reaction of 2-methoxyaniline 5 with 2-iodobenzoyl chloride 2. Scheme 9: (a) The reaction was carried out overnight at 0°C to room temperature in 98% yield using triethylamine as base and dichloromethane as solvent; (b) The reaction was carried out in the presence of potassium carbonate with copper (I) iodide as catalyst and ethylene glycol and 2-propanol as solvents with microwave radiation (150 W, 80 °C) for 30 min (twice) in 63% yield. Synthesis of 2-(4-nitrophenylthio)-N-(2-methoxyphenyl)benzamide (1): 2-Iodo-N-(2-methoxyphenyl)benzamide 3 (0.355 g, 1.0 mmol), copper(I) iodide (20 mg, 0.1 mmol), potassium carbonate (0.276 g, 2.0 mmol), and 4-nitrobenzothiophenol (0.155 g, 1 mmol) were added to a 10 mL reaction tube fitted with a PTFE liner. The reaction tube was evacuated and backfilled with dry nitrogen (cycled three times). Ethylene glycol (0.1 mL, 2.0 mmol) and 2-propanol (1 mL) were added via syringe at room temperature. The reaction tube was placed in a microwave reactor (CEM Explorer) and heated at 80°C and 150 W power for 30 min (twice). After the reaction was completed, it was cooled to room temperature. Ethyl acetate (~10 mL) was added, filtered and the reaction mixture was concentrated. The crude product was purified by rapid column chromatography on silica gel, using a hexane solution of 20% ethyl acetate as eluent. The final product was obtained as 2-(4-nitrophenylthio)-N-(2-methoxyphenyl)benzamide 1 as a light yellow crystalline solid (0.24 g, 63%). 1H NMR (400 MHz, CDCl3) δ 8.40 (d, J = 8.0 Hz, 1H), 8.39 (s, 1H, overlapping signals), 8.05 (ddd, J = 9.2, 2.4, 1.6 Hz, 2H), 7.77 (dd, J = 6.4, 2.4 Hz, 1H), 7.56-7.49 (m, 3H), 7.29- 7.25 (m, 2H), 7.06 (ddd, J = 9.2, 7.6, 1.6 Hz, 1H), 6.95 (dt, J = 8.8, 0.8, 1.2 Hz, 1H), 6.85 (dd, J = 8.0, 0.8 Hz, 1H), 3.78 (s, 3H). 13C NMR (100 MHz, CDCl3) δ 165.44, 148.22, 146.87, 146.15, 140.63, 135.76, 131.66, 130.09, 129.87, 129.49, 128.79 (2C), 127.54, 124.54, 124.35 (2C), 121.37, 120.05, 110.19, 55.88. MS (ESI): m/z 402.99 (M + Na)+.

References

[1] Patent: US2007/99919, 2007, A1. Location in patent: Page/Page column 26; 27
[2] ChemMedChem, 2012, vol. 7, # 7, p. 1217 - 1229

RN-18 Preparation Products And Raw materials

Raw materials

Preparation Products

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431980-38-0, RN-18Related Search:

RN-18

RN18;RN 18

Benzamide, N-(2-methoxyphenyl)-2-[(4-nitrophenyl)thio]-

RN18,RN 18,inhibit,Inhibitor,Human immunodeficiency virus,HIV,RN-18

N-(2-Methoxyphenyl)-2-((4-nitrophenyl)thio)benzamide

RN-18, 10 mM in DMSO

431980-38-0