5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)-5-methyluridine
- Product Name
- 5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)-5-methyluridine
- CAS No.
- 2095417-42-6
- Chemical Name
- 5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)-5-methyluridine
- Synonyms
- 5’-Azido-5’-deoxy-2’-O-(2-methoxyethyl)-5-methyluridine;5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)-5-methyluridine
- CBNumber
- CB93334279
- Molecular Formula
- C13H19N5O6
- Formula Weight
- 341.32
- MOL File
- 2095417-42-6.mol
5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)-5-methyluridine Chemical Properties,Usage,Production
Uses
5’-Azido-5’-deoxy-2’-O-(2-methoxyethyl)-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 5’-Azido-5’-deoxy-2’-O-(2-methoxyethyl)-5-methyluridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
References
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)-5-methyluridine Preparation Products And Raw materials
Raw materials
Preparation Products
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