5'-Azido-5'-deoxy-5-methyluridine

Product Name: 5'-Azido-5'-deoxy-5-methyluridine
CAS No.: 1187022-65-6
Chemical Name: 5'-Azido-5'-deoxy-5-methyluridine
Synonyms: 5'-azido-5-methyluridine;5’-Azido-5’-deoxy-5-methyluridine;5'-Azido-5'-deoxy-5-methyluridine
CBNumber: CB93334284
Molecular Formula: C10H13N5O5
Formula Weight: 283.24
MOL File: 1187022-65-6.mol

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Hazard and Precautionary Statements (GHS)

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5'-Azido-5'-deoxy-5-methyluridine Chemical Properties,Usage,Production

Uses

5’-Azido-5’-deoxy-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 5’-Azido-5’-deoxy-5-methyluridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

References

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005

5'-Azido-5'-deoxy-5-methyluridine Preparation Products And Raw materials

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1187022-65-6, 5'-Azido-5'-deoxy-5-methyluridineRelated Search:

3',5'-Anhydrothymidine 3'-DEOXY-5-METHYLURIDINE 5-(Hydroxymethyl)uridine 5'-AMINO-5'-DEOXYTHYMIDINE NSC98948-d3

5'-Azido-5'-deoxy-5-methyluridine

5’-Azido-5’-deoxy-5-methyluridine

5'-azido-5-methyluridine

1187022-65-6