5'-Azido-5'-deoxy-5-methyluridine
- Product Name
- 5'-Azido-5'-deoxy-5-methyluridine
- CAS No.
- 1187022-65-6
- Chemical Name
- 5'-Azido-5'-deoxy-5-methyluridine
- Synonyms
- 5'-azido-5-methyluridine;5’-Azido-5’-deoxy-5-methyluridine;5'-Azido-5'-deoxy-5-methyluridine
- CBNumber
- CB93334284
- Molecular Formula
- C10H13N5O5
- Formula Weight
- 283.24
- MOL File
- 1187022-65-6.mol
5'-Azido-5'-deoxy-5-methyluridine Chemical Properties,Usage,Production
Uses
5’-Azido-5’-deoxy-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 5’-Azido-5’-deoxy-5-methyluridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
References
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
5'-Azido-5'-deoxy-5-methyluridine Preparation Products And Raw materials
Raw materials
Preparation Products
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