ABT594 2HCL
- Product Name
- ABT594 2HCL
- CAS No.
- 209326-19-2
- Chemical Name
- ABT594 2HCL
- Synonyms
- ABT594 2HCL;Tebanicline dihydrochloride
- CBNumber
- CB93339845
- Molecular Formula
- C9H12Cl2N2O
- Formula Weight
- 235.11
- MOL File
- 209326-19-2.mol
ABT594 2HCL Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: ≥ 34 mg/mL (125.20 mM)
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-6400
- Product name
- Tebanicline(dihydrochloride)
- Purity
- 98.91%
- Packaging
- 5mg
- Price
- $108
- Updated
- 2021/12/16
- Product number
- CS-6400
- Product name
- Tebanicline(dihydrochloride)
- Purity
- 98.91%
- Packaging
- 10mg
- Price
- $156
- Updated
- 2021/12/16
- Product number
- CS-6400
- Product name
- Tebanicline(dihydrochloride)
- Purity
- 98.91%
- Packaging
- 25mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- CS-6400
- Product name
- Tebanicline(dihydrochloride)
- Purity
- 98.91%
- Packaging
- 50mg
- Price
- $528
- Updated
- 2021/12/16
- Product number
- CS-6400
- Product name
- Tebanicline(dihydrochloride)
- Purity
- 98.91%
- Packaging
- 100mg
- Price
- $888
- Updated
- 2021/12/16
ABT594 2HCL Chemical Properties,Usage,Production
Uses
Tebanicline dihydrochloride (Ebanicline dihydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM[1].
in vivo
Tebanicline is a potent antinociceptive agent with full efficacy in models of acute and persistent pain and that these effects are mediated predominately by an action at central neuronal nAChRs[2]. Tebanicline produces significant antinociceptive effects in mice against both acute noxious thermal stimulation. ABT-594 is orally active, but 10-fold less potent by this route than after i.p. administration. The antinociceptive effect of ABT-594 is prevented, but not reversed, by the noncompetitive neuronal nicotinic acetylcholine receptor antagonist[3]. Tebanicline has antinociceptive effects in rat models of acute thermal, persistent chemical, and neuropathic pain. Direct injection of tebanicline into the nucleus raphe magnus (NRM) is antinociceptive in a thermal threshold test and destruction of serotonergic neurons in the NRM attenuates the effect of systemic tebanicline[4].
References
[1] Donnelly-Roberts DL, et al. ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization.J Pharmacol Exp Ther. 1998 May;285(2):777-86. PMID:9580626
[2] Bannon AW, et al. ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective antinociceptive agent acting via neuronal nicotinic acetylcholine receptors: II. In vivo characterization. J Pharmacol Exp Ther. 1998 May;285(2):787-94. PMID:9580627
[3] Decker MW, et al. Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice. Eur J Pharmacol. 1998 Apr 3;346(1):23-33. DOI:10.1016/s0014-2999(98)00042-9
[4] Decker MW, et al. The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594. J Physiol Paris. 1998 Jun-Aug;92(3-4):221-4. DOI:10.1016/s0928-4257(98)80014-4
ABT594 2HCL Preparation Products And Raw materials
Raw materials
Preparation Products
ABT594 2HCL Suppliers
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