Tetrazine-NHS Ester

Product Name: Tetrazine-NHS Ester
CAS No.: 1616668-55-3
Chemical Name: Tetrazine-NHS Ester
Synonyms: Tetrazine-NHS Ester;Tetrazine-Ph-NHS ester;Tetrazine-NHS Ester (CCT-1127);3-(4-phenylacetic acid)-1,2,4,5-tetrazine succinimidyl ester;2,5-Dioxo-1-pyrrolidinyl 4-(1,2,4,5-tetrazin-3-yl)benzeneacetate;2,5-Dioxopyrrolidin-1-yl 2-(4-(1,2,4,5-tetrazin-3-yl)phenyl)acetate;Benzeneacetic acid, 4-(1,2,4,5-tetrazin-3-yl)-, 2,5-dioxo-1-pyrrolidinyl ester
CBNumber: CB93345123
Molecular Formula: C14H11N5O4
Formula Weight: 313.27
MOL File: 1616668-55-3.mol

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Tetrazine-NHS Ester Property

Boiling point:: 547.5±60.0 °C(Predicted)
Density: 1.53±0.1 g/cm3(Predicted)
storage temp.: -20°C, protect from light
solubility: DMSO : 100 mg/mL (319.21 mM; Need ultrasonic)
pka: 0.65±0.10(Predicted)
form: Solid
color: Pink to red

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 901989
Product name: Tetrazine-NHS ester
Packaging: 25MG
Price: $346
Updated: 2023/01/07

TCI Chemical

Product number: T4125
Product name: Tetrazine-NHS Ester
Packaging: 10MG
Price: $146
Updated: 2025/07/31

Chem-Impex

Product number: 35093
Product name: Tetrazine-NHS ester
Purity: ≥ 95% (HPLC)
Packaging: 25MG
Price: $150
Updated: 2021/12/16

Chem-Impex

Product number: 35093
Product name: Tetrazine-NHS ester
Purity: ≥ 95% (HPLC)
Packaging: 100MG
Price: $295
Updated: 2021/12/16

Chem-Impex

Product number: 35093
Product name: Tetrazine-NHS ester
Purity: ≥ 95% (HPLC)
Packaging: 5MG
Price: $75
Updated: 2021/12/16

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Tetrazine-NHS Ester Chemical Properties,Usage,Production

Description

Tetrazine-NHS Ester is a NHS activated tetrazine linker. NHS ester is very reactive with amine containing molecule. Methyltetrazine enable fast click reaction with TCO (trans-cycloctene).

Uses

Tetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Tetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

IC 50

Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Tetrazine-NHS Ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Tetrazine-NHS Ester manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Tetrazine NHS ester 1616668-55-3
Price: US $0.00/mg
Min. Order: 25mg
Purity: >99.00%
Supply Ability: 100mg
Release date: 2024-03-20

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1616668-55-3