ADX-102 (NS-2)

Product Name: ADX-102 (NS-2)
CAS No.: 916056-79-6
Chemical Name: ADX-102 (NS-2)
Synonyms: Reproxzlap;Reproxalap;ADX-102 (NS-2);ADX-102 (Reproxalap;Reproxalap (ADX-102);Reproxalap, 10 mM in DMSO;2-(3-Amino-6-chloroquinolin-2-yl)propan-2-ol;2-Quinolinemethanol,3-amino-6-chloro-α,α-dimethyl-;2-Quinolinemethanol, 3-amino-6-chloro-α,α-dimethyl-;Inhibitor,NS 2,Reproxalap,ADX 102,ADX102,inhibit,NS2
CBNumber: CB93358334
Molecular Formula: C12H13ClN2O
Formula Weight: 236.7
MOL File: 916056-79-6.mol

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ADX-102 (NS-2) Property

Boiling point:: 410.5±40.0 °C(Predicted)
Density: 1.324±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (422.48 mM; Need ultrasonic)
form: Solid
pka: 13.07±0.29(Predicted)
color: Light yellow to yellow
InChI: InChI=1S/C12H13ClN2O/c1-12(2,16)11-9(14)6-7-5-8(13)3-4-10(7)15-11/h3-6,16H,14H2,1-2H3
InChIKey: GUHFUVLKYSQIOQ-UHFFFAOYSA-N
SMILES: CC(C1=C(N)C=C2C(=N1)C=CC(Cl)=C2)(O)C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ambeed

Product number: A1328056
Product name: 2-(3-Amino-6-chloroquinolin-2-yl)propan-2-ol
Purity: 98%
Packaging: 25mg
Price: $165
Updated: 2021/12/16

Ambeed

Product number: A1328056
Product name: 2-(3-Amino-6-chloroquinolin-2-yl)propan-2-ol
Purity: 98%
Packaging: 50mg
Price: $248
Updated: 2021/12/16

Ambeed

Product number: A1328056
Product name: 2-(3-Amino-6-chloroquinolin-2-yl)propan-2-ol
Purity: 98%
Packaging: 100mg
Price: $345
Updated: 2021/12/16

Ambeed

Product number: A1328056
Product name: 2-(3-Amino-6-chloroquinolin-2-yl)propan-2-ol
Purity: 98%
Packaging: 250mg
Price: $572
Updated: 2021/12/16

DC Chemicals

Product number: DC11097
Product name: ADX-102(Reproxalap;NS-2)
Purity: >98%
Packaging: 100mg
Price: $650
Updated: 2021/12/16

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ADX-102 (NS-2) Chemical Properties,Usage,Production

Uses

Reproxalap (ADX-102) is an active aldehyde sequestering agent. Reproxalap reduces the PKCα activity. Reproxalap blocks caspase 3/7 activation. Reproxalap protects cells from the cytotoxicity of C18:0-al. Reproxalap has anti-inflammatory and pain-relieving effects. Reproxalap is used in studies of dry eye, allergic conjunctivitis, and non-infectious anterior uveitis[1][2][3][4][5].

in vivo

Reproxalap (30-100 mg/kg, once or twice a day) shows a dose-dependent reduction in pain-related behaviors in acute pain models^[3].
Reproxalap (10 mg/kg, intraperitoneal injection, single dose) significantly reduces the formation of N-retinyl-phosphatidylethanolamine (A2E) in the retinas of mice with macular degeneration^[5].
Reproxalap (25-50 μg, IVT, injected in five doses after LPS (HY-D1056) induction) can improve eye scores in uveitis rats^[5].

Animal Model:	Carrageenaninduced and Complete Freund’s Adjuvant (CFA)-induced models in mice^[3]
Dosage:	30, 100 mg/kg; once a day or twice a day
Administration:
Result:	Was effective in thermal hyperalgesia in the CFA-induced model at both 100 mg/kg QD and BID doses; in the carrageenan-induced model, and was effective at 30 mg/kg BID and 100 mg/kg BID doses. Was effective in mechanical allodynia only in the CFA-induced model at a 100 mg/kg BID dose; in the carrageenan-induced model, was not effective. Had a mild effect on swelling in the CFA-induced model at 30 mg/kg BID and 100 mg/kg BID doses; in the carrageenan-induced model, had a mild effect at a 100 mg/kg QD dose.

Animal Model:	A mouse knockout model (abcr-/-) of macular degeneration (MD) ^[5]
Dosage:	10 mg/kg; single dose
Administration:	Intraperitoneal injection (i.p.)
Result:	Reduced the formation of N-retinylidene-N-retinylethanolamine (A2E) in the retina by 71% without affecting dark adaptation or body weight.

Animal Model:	A rat model of lipopolysaccharide (LPS)-induced uveitis^[5]
Dosage:	10 mg/kg 50 μg at hours 1, 3, 7, 10 and 17, after LPS induction, or injection 25 μg at 1 hour after LPS induction
Administration:	Intravitreal (IVT)
Result:	Improved the eye examination scores, enhancing the retinal-choroidal ratings.

IC 50

PKCα; Caspase 3; Caspase-7

References

[1] Ochoa CA, et al. Aldehyde Trapping by ADX-102 Is Protective against Cigarette Smoke and Alcohol Mediated Lung Cell Injury. Biomolecules. 2022 Mar 2;12(3):393. DOI:10.3390/biom12030393
[2] Rizzo WB, et al. Sj?gren-Larsson syndrome: A biochemical rationale for using aldehyde-reactive therapeutic agents. Mol Genet Metab Rep. 2021 Dec 23;30:100839. DOI:10.1016/j.ymgmr.2021.100839
[3] Susan Macdonald, et al. ADX-102, a novel aldehyde trap, reduces nociceptive behavior in mouse models of carrageenan and CFA induced pain.
[4] Reproxalap Phase 2b Dry Eye Disease Results.
[5] Susan G. Macdonald, Ph.D., et al. Novel Small Molecule Aldehyde Sequestering Agents Demonstrate Broad Therapeutic Potential for Ocular Inflammation.

ADX-102 (NS-2) Preparation Products And Raw materials

Raw materials

Preparation Products

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ADX-102 (NS-2) Suppliers

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916056-79-6, ADX-102 (NS-2)Related Search:

ADX-102 (NS-2)

Reproxalap

2-Quinolinemethanol, 3-amino-6-chloro-α,α-dimethyl-

ADX-102 (Reproxalap

2-(3-Amino-6-chloroquinolin-2-yl)propan-2-ol

Reproxzlap

Reproxalap (ADX-102)

Inhibitor,NS 2,Reproxalap,ADX 102,ADX102,inhibit,NS2

2-Quinolinemethanol,3-amino-6-chloro-α,α-dimethyl-

Reproxalap, 10 mM in DMSO

916056-79-6