ChemicalBook > CAS DataBase List > DLin-KC2-DMA

DLin-KC2-DMA

Product Name
DLin-KC2-DMA
CAS No.
1190197-97-7
Chemical Name
DLin-KC2-DMA
Synonyms
KC2;DLin-KC2-DMA;DLin-KC-2-DMA,inhibit,Inhibitor,DLin KC2 DMA,DLinKC2DMA;1,3-Dioxolane-4-ethanamine, N,N-dimethyl-2,2-di-(9Z,12Z)-9,12-octadecadien-1-yl-;2-[2,2-bis[(9Z,12Z)-octadeca-9,12-dienyl]-1,3-dioxolan-4-yl]-N,N-dimethylethanamine;2-(2,2-Di((9Z,12Z)-octadeca-9,12-dien-1-yl)-1,3-dioxolan-4-yl)-N,N-dimethylethanamine
CBNumber
CB93361767
Molecular Formula
C43H79NO2
Formula Weight
642.09
MOL File
1190197-97-7.mol
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DLin-KC2-DMA Property

Boiling point:
668.1±40.0 °C(Predicted)
Density 
0.885±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C,unstable in solution, ready to use.
solubility 
Soluble in Ethanol, DMSO, DMF
pka
9.32±0.28(Predicted)
form 
Liquid
color 
Colorless to light yellow
InChIKey
LRFJOIPOPUJUMI-MNMREVDWSA-N
SMILES
O1CC(CCN(C)C)OC1(CCCCCCCCC=CCC=CCCCCC)CCCCCCCC/C=C\C/C=C\CCCCC
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Biorbyt Ltd
Product number
orb573022
Product name
DLin-KC2-DMA
Purity
>98%
Packaging
25mg
Price
$838.1
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573022
Product name
DLin-KC2-DMA
Purity
>98%
Packaging
100mg
Price
$1504.5
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573022
Product name
DLin-KC2-DMA
Purity
>98%
Packaging
250mg
Price
$2691.1
Updated
2021/12/16
DC Chemicals
Product number
DC12381
Product name
DLin-KC2-DMA
Purity
>98%
Packaging
25mg
Price
$550
Updated
2021/12/16
DC Chemicals
Product number
DC12381
Product name
DLin-KC2-DMA
Purity
>98%
Packaging
250mg
Price
$1800
Updated
2021/12/16
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DLin-KC2-DMA Chemical Properties,Usage,Production

Description

DLin-KC2-DMA is a useful ionizable lipid for siRNA delivery. It was formulated and characterized in SNALP and demonstrated to have in vivo activity at siRNA doses as low as 0.01 mg/kg in rodents and 0.1 mg/kg in nonhuman primates.

Uses

DLin-KC2-DMA, also known as KC2 (2,2-dilinoleyl-4-(2-dimethylaminoethyl)-[1,3]-dioxolane) is an optimized ionizable cationic lipid (ICL) with a reported apparent pKa of 6.7. This pKa ensures an efficient encapsulation of nucleic acid polymers at low pH, a nearly neutral surface charge for the LNPs in the circulation at physiological pH, and a high positive surface charge at endosomal pH. More recently, it was determined that LNPs containing KC2 generated liposomal structures when the KC2 is protonated at pH 4, while forming electron-dense structures at pH 7.4. It is an ionizable cationic lipid that has been used to form lipid nanoparticles (LNPs) encapsulating siRNA or plasmid DNA for use in vitro and in vivo. LNPs containing DLin-KC2-DMA selectively accumulate in mice's liver after intravenous or intramuscular administration or localize to the retinal pigment epithelium and Müller glia after subretinal administration. DLin-KC2-DMA-containing LNPs encapsulating siRNA targeting F7 mRNA, which encodes Factor VII, reduce serum Factor VII levels in mice. Intravenous administration of DLin-KC2-DMA-containing LNPs encapsulating siRNA targeting AR mRNA, which encodes the androgen receptor, decreases serum prostate-specific antigen (PSA) and tumour androgen receptor levels in an LNCaP prostate cancer mouse xenograft model[1].

References

[1] Ramezanpour, M. et al. “Ionizable amino lipid interactions with POPC: implications for lipid nanoparticle function?.” Nanoscale 30 (2019): 14141–14146.

DLin-KC2-DMA Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DLin-KC2-DMA manufacturers

Career Henan Chemical Co
Product
DLIN-KC2-DMA 1190197-97-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%HPLC
Supply Ability
100KG
Release date
2020-02-01

1190197-97-7, DLin-KC2-DMARelated Search:


  • DLin-KC2-DMA
  • 1,3-Dioxolane-4-ethanamine, N,N-dimethyl-2,2-di-(9Z,12Z)-9,12-octadecadien-1-yl-
  • 2-(2,2-Di((9Z,12Z)-octadeca-9,12-dien-1-yl)-1,3-dioxolan-4-yl)-N,N-dimethylethanamine
  • 2-[2,2-bis[(9Z,12Z)-octadeca-9,12-dienyl]-1,3-dioxolan-4-yl]-N,N-dimethylethanamine
  • DLin-KC-2-DMA,inhibit,Inhibitor,DLin KC2 DMA,DLinKC2DMA
  • KC2
  • 1190197-97-7