ChemicalBook > CAS DataBase List > DLin-KC2-DMA

DLin-KC2-DMA

Product Name: DLin-KC2-DMA
CAS No.: 1190197-97-7
Chemical Name: DLin-KC2-DMA
Synonyms: KC2;DLin-KC2-DMA;DLin-KC2-DMA, 10 mM in DMSO;DLin-KC-2-DMA,inhibit,Inhibitor,DLin KC2 DMA,DLinKC2DMA;1,3-Dioxolane-4-ethanamine, N,N-dimethyl-2,2-di-(9Z,12Z)-9,12-octadecadien-1-yl-;2-[2,2-bis[(9Z,12Z)-octadeca-9,12-dienyl]-1,3-dioxolan-4-yl]-N,N-dimethylethanamine;2-(2,2-Di((9Z,12Z)-octadeca-9,12-dien-1-yl)-1,3-dioxolan-4-yl)-N,N-dimethylethanamine
CBNumber: CB93361767
Molecular Formula: C43H79NO2
Formula Weight: 642.09
MOL File: 1190197-97-7.mol

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DLin-KC2-DMA Property

Boiling point:: 668.1±40.0 °C(Predicted)
Density: 0.885±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C,unstable in solution, ready to use.
solubility: Soluble in Ethanol, DMSO, DMF
pka: 9.32±0.28(Predicted)
form: Liquid
color: Colorless to light yellow
InChIKey: LRFJOIPOPUJUMI-MNMREVDWSA-N
SMILES: O1CC(CCN(C)C)OC1(CCCCCCCCC=CCC=CCCCCC)CCCCCCCC/C=C\C/C=C\CCCCC

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb573022
Product name: DLin-KC2-DMA
Purity: >98%
Packaging: 25mg
Price: $838.1
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573022
Product name: DLin-KC2-DMA
Purity: >98%
Packaging: 100mg
Price: $1504.5
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573022
Product name: DLin-KC2-DMA
Purity: >98%
Packaging: 250mg
Price: $2691.1
Updated: 2021/12/16

DC Chemicals

Product number: DC12381
Product name: DLin-KC2-DMA
Purity: >98%
Packaging: 25mg
Price: $550
Updated: 2021/12/16

DC Chemicals

Product number: DC12381
Product name: DLin-KC2-DMA
Purity: >98%
Packaging: 250mg
Price: $1800
Updated: 2021/12/16

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DLin-KC2-DMA Chemical Properties,Usage,Production

Description

DLin-KC2-DMA is a useful ionizable lipid for siRNA delivery. It was formulated and characterized in SNALP and demonstrated to have in vivo activity at siRNA doses as low as 0.01 mg/kg in rodents and 0.1 mg/kg in nonhuman primates.

Uses

DLin-KC2-DMA, also known as KC2 (2,2-dilinoleyl-4-(2-dimethylaminoethyl)-[1,3]-dioxolane) is an optimized ionizable cationic lipid (ICL) with a reported apparent pKa of 6.7. This pKa ensures an efficient encapsulation of nucleic acid polymers at low pH, a nearly neutral surface charge for the LNPs in the circulation at physiological pH, and a high positive surface charge at endosomal pH. More recently, it was determined that LNPs containing KC2 generated liposomal structures when the KC2 is protonated at pH 4, while forming electron-dense structures at pH 7.4. It is an ionizable cationic lipid that has been used to form lipid nanoparticles (LNPs) encapsulating siRNA or plasmid DNA for use in vitro and in vivo. LNPs containing DLin-KC2-DMA selectively accumulate in mice's liver after intravenous or intramuscular administration or localize to the retinal pigment epithelium and Müller glia after subretinal administration. DLin-KC2-DMA-containing LNPs encapsulating siRNA targeting F7 mRNA, which encodes Factor VII, reduce serum Factor VII levels in mice. Intravenous administration of DLin-KC2-DMA-containing LNPs encapsulating siRNA targeting AR mRNA, which encodes the androgen receptor, decreases serum prostate-specific antigen (PSA) and tumour androgen receptor levels in an LNCaP prostate cancer mouse xenograft model[1].

in vivo

DLin-KC2-DMA contained-LNP siRNA systems (5 mg/kg; i.v.; single) effectively silences target genes in APcs in vivo^[1].

Animal Model:	Naive C57BL/6 mice^[1].
Dosage:	3 or 5 mg/kg (DLin-KC2-DMA contained-LNPs)
Administration:	Intravenous injection; single.
Result:	Significantly reduced GAPDH production in peritoneal cavity macrophages and dendritic cells and in the spleen-derived APCs when at 5 mg/kg.

References

[1] Ramezanpour, M. et al. “Ionizable amino lipid interactions with POPC: implications for lipid nanoparticle function?.” Nanoscale 30 (2019): 14141–14146.

DLin-KC2-DMA Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DLin-KC2-DMA manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: DLin-KC2-DMA 1190197-97-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-22

Career Henan Chemical Co

Product: DLIN-KC2-DMA 1190197-97-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%HPLC
Supply Ability: 100KG
Release date: 2020-02-01

1190197-97-7, DLin-KC2-DMARelated Search:

DLin-KC2-DMA

1,3-Dioxolane-4-ethanamine, N,N-dimethyl-2,2-di-(9Z,12Z)-9,12-octadecadien-1-yl-

2-(2,2-Di((9Z,12Z)-octadeca-9,12-dien-1-yl)-1,3-dioxolan-4-yl)-N,N-dimethylethanamine

2-[2,2-bis[(9Z,12Z)-octadeca-9,12-dienyl]-1,3-dioxolan-4-yl]-N,N-dimethylethanamine

DLin-KC-2-DMA,inhibit,Inhibitor,DLin KC2 DMA,DLinKC2DMA

KC2

DLin-KC2-DMA, 10 mM in DMSO

1190197-97-7