Bendamustine Hydrochloride Monohydrate
Structure- Product Name
- Bendamustine Hydrochloride Monohydrate
- CAS No.
- 1374784-02-7
- Chemical Name
- Bendamustine Hydrochloride Monohydrate
- Synonyms
- Bendamustine HCL Monohydrate;Bendamustine Hydrochloride Monohydrate;4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid hydrochloride hydrate
- CBNumber
- CB93361787
- Molecular Formula
- C16H24Cl3N3O3
- Formula Weight
- 412.74
- MOL File
- 1374784-02-7.mol
Bendamustine Hydrochloride Monohydrate Property
- storage temp.
- room temp
- solubility
- H2O: >30 mg/mL
- form
- powder
- color
- off-white
- Water Solubility
- H2O: >30mg/mL
- InChI
- InChI=1S/C16H21Cl2N3O2.ClH.H2O/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23;;/h5-6,11H,2-4,7-10H2,1H3,(H,22,23);1H;1H2
- InChIKey
- TWBJYCLUHINEDN-UHFFFAOYSA-N
- SMILES
- CN1C(=NC2=CC(N(CCCl)CCCl)=CC=C12)CCCC(=O)O.Cl.O
Safety
- WGK Germany
- WGK 3
- Storage Class
- 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects - Hazard Classifications
- Acute Tox. 3 Oral
Carc. 2
Muta. 2
Repr. 2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H341Suspected of causing genetic defects
H351Suspected of causing cancer
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B5437
- Product name
- Bendamustine hydrochloride hydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $168
- Updated
- 2026/04/30
- Product number
- B5437
- Product name
- Bendamustine hydrochloride hydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $665
- Updated
- 2026/04/30
Bendamustine Hydrochloride Monohydrate Chemical Properties,Usage,Production
Structure
Commercial bendamustine hydrochloride monohydrate crystallizes in the monoclinic space group P21/c (14), with a = 4.71348(4) Å, b = 47.5325(3) Å, c = 8.97458 (5) Å, β = 96.6515(8)°, V = 1997.161(23) Å3, and Z = 4[1].
Uses
Bendamustine hydrochloride monohydrate (marketed as Treanda) is a nitrogen mustard purine analog alkylator used to treat chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphomas. Bendamustine is a nitrogen mustard drug used to treat chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL). Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases, resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Biological Activity
Bendamustine is a therapeutic agent employed in treating lymphomas and chronic lymphocytic leukemia. It may be useful in central nervous system (CNS) malignancies treatment regimen due to its penetration capacity into brain tissue. Bendamustine is a promising candidate for non-Hodgkin lymphoma and Hodgkin lymphoma therapies.', 'Bendamustine hydrochloride is a DNA-alkylator with a distinct pattern of activity. Bendamustine activates DNA-damage stress response and apoptosis; inhibits mitotic checkpoints; and induces mitotic catastrophe.
References
[1] J. Kaduk. “Powder X-ray diffraction of bendamustine hydrochloride monohydrate, C16H22Cl2N3O2Cl·H2O.” Powder Diffraction 34 1 (2018): 74–75.
Bendamustine Hydrochloride Monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Bendamustine Hydrochloride Monohydrate Suppliers
- Tel
- 0571-5683-8096 17302275155
- tanglulu1129@163.com
- Country
- China
- ProdList
- 127
- Advantage
- 58
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 5896
- Advantage
- 58
- Tel
- 0317-5296180 15533709196
- enkepharma@126.com;sale@enkepharma.com
- Country
- China
- ProdList
- 2335
- Advantage
- 55
- Tel
- +8615255079626
- eric@witopchemical.com
- Country
- China
- ProdList
- 23541
- Advantage
- 58
- Tel
- 15377653770 17771788359
- Fax
- 027-59207796
- w13429867250@163.com
- Country
- China
- ProdList
- 1886
- Advantage
- 58
- Tel
- +8618051385538
- donboo@donboo.com
- Country
- China
- ProdList
- 9363
- Advantage
- 58
- Tel
- 029-81024372 17792795018
- Fax
- 029-88380327
- 1053@dideu.com
- Country
- China
- ProdList
- 9999
- Advantage
- 58
- Tel
- 0731-85561023 18973109536
- hengkangapi@hengkangapi.com
- Country
- China
- ProdList
- 402
- Advantage
- 58
- Tel
- 029-81310890 13571859809
- info@pushanshiye.com
- Country
- China
- ProdList
- 9954
- Advantage
- 58
- Tel
- 19359985961
- 2430503320@qq.com
- Country
- China
- ProdList
- 1452
- Advantage
- 58
View Lastest Price from Bendamustine Hydrochloride Monohydrate manufacturers
- Product
- Bendamustine Hydrochloride Monohydrate 1374784-02-7
- Price
- US $5.00-0.50/KG
- Min. Order
- 1KG
- Purity
- 99% hplc
- Supply Ability
- 500TONS
- Release date
- 2025-05-29