PC Alkyne-PEG4-NHS carbonate ester

Product Name: PC Alkyne-PEG4-NHS carbonate ester
CAS No.: 1802907-98-7
Chemical Name: PC Alkyne-PEG4-NHS carbonate ester
Synonyms: PC Alkyne-PEG4-NHS ester;PC Alkyne-PEG4-NHS carbonate ester;2,5-Dioxopyrrolidin-1-yl (1-(5-methoxy-2-nitro-4-((17-oxo-4,7,10,13-tetraoxa-16-azaicos-1-yn-20-yl)oxy)phenyl)ethyl) carbonate;Carbonic acid, 2,5-dioxo-1-pyrrolidinyl 1-[5-methoxy-2-nitro-4-[(4-oxo-8,11,14,17-tetraoxa-5-azaeicos-19-yn-1-yl)oxy]phenyl]ethyl ester
CBNumber: CB93363978
Molecular Formula: C29H39N3O14
Formula Weight: 653.63
MOL File: 1802907-98-7.mol

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PC Alkyne-PEG4-NHS carbonate ester Property

Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: Storage temp. -20°C
form: Viscous Liquid
pka: 15.38±0.46(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-22956
Product name: PCAlkyne-PEG4-NHScarbonateester
Purity: 95%
Packaging: 10mg
Price: $95
Updated: 2021/12/16

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PC Alkyne-PEG4-NHS carbonate ester Chemical Properties,Usage,Production

Description

PC Alkyne-PEG4-NHS carbonate ester is a photocleavable linker with an alkyne and NHS carbonate ester end group. The NHS ester can react with primary amines. The alkyne can participate in copper-catalyzed Click Chemistry reactions with azide moieties.

Uses

PC Alkyne-PEG4-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. PC Alkyne-PEG4-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

PC Alkyne-PEG4-NHS carbonate ester Preparation Products And Raw materials

Raw materials

Preparation Products

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PC Alkyne-PEG4-NHS carbonate ester Suppliers

China 24 United States 4 Global 28

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View Lastest Price from PC Alkyne-PEG4-NHS carbonate ester manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: PC Alkyne-PEG4-NHS ester 1802907-98-7
Price: US $0.00/mg
Min. Order: 50mg
Purity: >99.00%
Supply Ability: 50mg
Release date: 2024-03-21

1802907-98-7, PC Alkyne-PEG4-NHS carbonate esterRelated Search:

PC Alkyne-PEG4-NHS carbonate ester

PC Alkyne-PEG4-NHS ester

Carbonic acid, 2,5-dioxo-1-pyrrolidinyl 1-[5-methoxy-2-nitro-4-[(4-oxo-8,11,14,17-tetraoxa-5-azaeicos-19-yn-1-yl)oxy]phenyl]ethyl ester

2,5-Dioxopyrrolidin-1-yl (1-(5-methoxy-2-nitro-4-((17-oxo-4,7,10,13-tetraoxa-16-azaicos-1-yn-20-yl)oxy)phenyl)ethyl) carbonate

1802907-98-7