ChemicalBook > CAS DataBase List > GSK3359088

GSK3359088

Product Name: GSK3359088
CAS No.: 1628830-21-6
Chemical Name: GSK3359088
Synonyms: CS-2741;EZM2302;GSK3359088;EZM2302 (GSK3359088);EZM 2302, 10 mM in DMSO;EZM2302;EZM-2302;EZM 2302;inhibit,Inhibitor,EZM2302,Histone Methyltransferase,EZM 2302,EZM-2302;Methyl 2-(2-(2-chloro-5-((R)-2-hydroxy-3-(methylamino)propoxy)phenyl)-6-(3,5-dimethylisoxazol-4-yl)-5-methylpyrimidin-4-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate;Methyl 2-[2-[2-chloro-5-[(2R)-2-hydroxy-3-(methylamino)propoxy]phenyl]-6-(3,5-dimethyl-4-isoxazolyl)-5-methyl-4-pyrimidinyl]-2,7-diazaspiro[3.5]nonane-7-carboxylate;methyl 2-(2-{2-chloro-5-[(2R)-2-hydroxy-3-(methylamino)propoxy]phenyl}-6-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methylpyrimidin-4-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate
CBNumber: CB93364258
Molecular Formula: C29H37ClN6O5
Formula Weight: 585.09
MOL File: 1628830-21-6.mol

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GSK3359088 Property

Boiling point:: 705.8±60.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:91.0(Max Conc. mg/mL);155.53(Max Conc. mM)
DMSO:91.0(Max Conc. mg/mL);155.53(Max Conc. mM)
form: A solid
pka: 13.79±0.20(Predicted)
color: White to off-white
InChIKey: OWCOTUVKROVONT-HXUWFJFHSA-N
SMILES: C1C2(CCN(C(OC)=O)CC2)CN1C1C(C)=C(C2=C(C)ON=C2C)N=C(C2=CC(OC[C@H](O)CNC)=CC=C2Cl)N=1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29954
Product name: EZM2302
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 29954
Product name: EZM2302
Packaging: 10mg
Price: $601
Updated: 2024/03/01

Cayman Chemical

Product number: 29954
Product name: EZM2302
Packaging: 5mg
Price: $319
Updated: 2024/03/01

AK Scientific

Product number: 3748EB
Product name: Methyl2-[2-[2-chloro-5-[(2R)-2-hydroxy-3-(methylamino)propoxy]phenyl]-6-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methylpyrimidin-4-yl]-2,7-diazaspiro[3.5]nonane-7-carboxylate
Packaging: 5mg
Price: $452
Updated: 2021/12/16

ChemScene

Product number: CS-0034242
Product name: EZM2302
Purity: 99.49%
Packaging: 5mg
Price: $200
Updated: 2021/12/16

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GSK3359088 Chemical Properties,Usage,Production

Uses

EZM 2302 is a potent and orally active CARM1 inhibitor with an IC50 value of 6 nM. EZM 2302 shows antiproliferative activity and anti-tumor activity. EZM 2302 inhibits PABP1 and SMB expression[1].

in vivo

EZM 2302 (37.5, 75, 150, 300 mg/kg; p.o.; twice daily for 21 days) shows anti-tumor activity in mouse^[1].
Pharmacokinetic Parameters of EZM 2302 in CD-1 mouse and Sprague-Dawley rat^[1].

Parameters	IV(CD-1 mouse)	PO(CD-1 mouse)	IV (Sprague-Dawley rat)	PO (Sprague-Dawley rat)
Dose (mg/kg)	2	10	2	10
Blood:plasma ratio	1.2	1.2	2.6	ND
C_max(ng/mL)		177		113?±?22.4
T_max(h)		2.00		2.00
AUC_0-last(ng.h/mL)	767	568	352?±?30.6	453?±?89.3
AUC_0-inf(ng.h/mL)	772	577	372?±?43.3	487?±?102
t_1/2(h)	4.22	4.55	6.21?±?1.65	6.64?±?1.41
V_ss(L/kg)	6.53		35.6?±?1.30
CL (mL/min/kg)	43.2		90.5?±?10.5
Fa*Fg (%)		ND		80.7
F (%)		15.0		26.2?±?5.45

CD-1 mouse and Sprague-Dawley rats, 2 mg/kg iv; 10 mg/kg po^[1]

References

[1] Drew AE, et al. Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma. Sci Rep. 2017 Dec 21;7(1):17993. DOI:10.1038/s41598-017-18446-z

GSK3359088 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from GSK3359088 manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: EZM 2302 1628830-21-6
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

1628830-21-6, GSK3359088Related Search:

GSK3359088

EZM2302

EZM2302 (GSK3359088)

EZM2302;EZM-2302;EZM 2302

CS-2741

2,7-Diazaspiro[3.5]nonane-7-carboxylic acid, 2-[2-[2-chloro-5-[(2R)-2-hydroxy-3-(methylamino)propoxy]phenyl]-6-(3,5-dimethyl-4-isoxazolyl)-5-methyl-4-pyrimidinyl]-, methyl ester

Methyl 2-(2-(2-chloro-5-((R)-2-hydroxy-3-(methylamino)propoxy)phenyl)-6-(3,5-dimethylisoxazol-4-yl)-5-methylpyrimidin-4-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate

Methyl 2-[2-[2-chloro-5-[(2R)-2-hydroxy-3-(methylamino)propoxy]phenyl]-6-(3,5-dimethyl-4-isoxazolyl)-5-methyl-4-pyrimidinyl]-2,7-diazaspiro[3.5]nonane-7-carboxylate

inhibit,Inhibitor,EZM2302,Histone Methyltransferase,EZM 2302,EZM-2302

methyl 2-(2-{2-chloro-5-[(2R)-2-hydroxy-3-(methylamino)propoxy]phenyl}-6-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methylpyrimidin-4-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate

EZM 2302, 10 mM in DMSO

1628830-21-6

C29H37ClN6O5