ChemicalBook > CAS DataBase List > BAY-1251152

BAY-1251152

Product Name: BAY-1251152
CAS No.: 1610358-56-9
Chemical Name: BAY-1251152
Synonyms: BAY-1251152;(+)-BAY-1251152;(+)-Enitociclib;(±)-BAY-1251152;BAY 1251152 ，S8730;Enitociclib (BAY 1251152);(+)Enitociclib,(+) Enitociclib;BAY 1251152 ((+)-BAY 1251152 );(+)-5-fluoro-4-(4-fluoro-2-methoxy-phenyl)-N-[4-[(methylsulfonimidoyl)methyl]-2-pyridyl]pyridin-2-amine;(+)-5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-(4-((S-methylsulfonimidoyl)methyl)pyridin-2-yl)pyridin-2-amine
CBNumber: CB93364607
Molecular Formula: C19H18F2N4O2S
Formula Weight: 404.43
MOL File: 1610358-56-9.mol

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BAY-1251152 Property

Boiling point:: 494.2±55.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:97.15(Max Conc. mg/mL);240.21(Max Conc. mM)
form: Solid
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B119025
Product name: (+)-BAY-1251152
Packaging: 1mg
Price: $225
Updated: 2021/12/16

ChemScene

Product number: CS-0023124
Product name: (+)-BAY-1251152
Purity: 99.66%
Packaging: 5mg
Price: $228
Updated: 2021/12/16

ChemScene

Product number: CS-0023124
Product name: (+)-BAY-1251152
Purity: 99.66%
Packaging: 10mg
Price: $348
Updated: 2021/12/16

ChemScene

Product number: CS-0023124
Product name: (+)-BAY-1251152
Purity: 99.66%
Packaging: 50mg
Price: $1068
Updated: 2021/12/16

ChemScene

Product number: CS-0023124
Product name: (+)-BAY-1251152
Purity: 99.66%
Packaging: 2mg
Price: $132
Updated: 2021/12/16

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BAY-1251152 Chemical Properties,Usage,Production

Uses

(+)-Enitociclib ((+)-BAY-1251152) is an enanthiomer of BAY-1251152 with rotation (+). Enitociclib is a potent and selective CDK9 inhibitor with an IC50 of 3 nM. Enitociclib has anti-tumour activity[1][2].

in vivo

(+)-Enitociclib (Compound A’; 10 mg/kg; intravenous injection; once every seven days; for 14 days; female SCID mice) reaches a Treatment to Control ratios (T/C) by area of 0.29 and a T/C by weight of 0.24. Enitociclib inhibits tumour growth and had good tolerability^[2].

Animal Model:	Female SCID mice with OCI-LY-3 cells^[2]
Dosage:	10 mg/kg
Administration:	Intravenous injection; once every seven days; for 14 days
Result:	Inhibited tumour growth and had good tolerability.

IC 50

CDK9/CycT1: 3 nM (IC₅₀)

References

[1] Ulrich LüCKING, et al. 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group. WO2014076091A1.
[2] Use of Arne Scholz, et al. 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-n-{4-[(s-methylsulfonimidoyl)methyl]pyridin-2-yl}pyridin-2-amine for treating diffuse large b-cell lymphoma. WO2019158517A1.

BAY-1251152 Preparation Products And Raw materials

Raw materials

Preparation Products

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BAY-1251152 Suppliers

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1610358-56-9, BAY-1251152Related Search:

BAY-1251152

BAY 1251152 ((+)-BAY 1251152 )

(rac)-5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyridin-2-amine

(+)-BAY-1251152

(+)-5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl]pyridin-2-amine

(+)-Enitociclib

(+)Enitociclib,(+) Enitociclib

(+)-5-fluoro-4-(4-fluoro-2-methoxy-phenyl)-N-[4-[(methylsulfonimidoyl)methyl]-2-pyridyl]pyridin-2-amine

(+)-5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-(4-((S-methylsulfonimidoyl)methyl)pyridin-2-yl)pyridin-2-amine

(±)-BAY-1251152

Enitociclib (BAY 1251152)

BAY 1251152 ，S8730

1610358-56-9

C19H18F2N4O2S