VU0469650
- Product Name
- VU0469650
- CAS No.
- 1443748-47-7
- Chemical Name
- VU0469650
- Synonyms
- VU0469650;CID73755207;VU 0469650 HCl;VU 0469650 hydrochloride;VU 0469650, 10 mM in DMSO;VU0469650|||VU 0469650|||VU-0469650|||VU 0469650 HCl;3-[(3R)-3-METHYL-4-[(4-METHYLADAMANTAN-1-YL)CARBONYL]PIPERAZIN-1-YL]PYRIDINE-2-CARBONITRILE;2-Pyridinecarbonitrile, 3-[(3R)-3-methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-;3-[(3R)-3-Methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-2-pyridinecarbonitrile hydrochloride
- CBNumber
- CB93369783
- Molecular Formula
- C22H28N4O
- Formula Weight
- 364.48
- MOL File
- 1443748-47-7.mol
VU0469650 Property
- Boiling point:
- 584.7±50.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 100 mM,Ethanol: 50 mM
- pka
- 1.42±0.12(Predicted)
- form
- Solid
- color
- Off-white to light yellow
- optical activity
- [α]/D -41 to -51°, c =1 in methanol
N-Bromosuccinimide Price
- Product number
- 5379
- Product name
- VU0469650hydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $208
- Updated
- 2021/12/16
- Product number
- 5379
- Product name
- VU0469650hydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $870
- Updated
- 2021/12/16
- Product number
- V787585
- Product name
- VU0469650Hydrochloride
- Packaging
- 5mg
- Price
- $115
- Updated
- 2021/12/16
VU0469650 Chemical Properties,Usage,Production
Uses
VU 0469650 Hydrochloride is potent and selective negative allosteric modulators of metabotropic glutamate receptor 1 (mGlu1).
Biological Activity
VU0469650 is a brain-penetrant, potent and selective metabotropic glutamate receptor 1 (mGlu1) negative allosteric modulator (NAM). VU0469650 selectively inhibits glu-induced Ca2+ influx in human mGluR1-expressing HEK 293A (EC50 = 99 nM with [Glu] = EC20 for 1.9 min, then EC100 for 1.7 min; inactive against cells expressing human mGlu2-8 at 10 μM) with no affinity toward a panel of 68 clinically relevant GPCRs, ion channels, kinases, and transporters. Prior administration of VU0469650 in mice in vivo (60 mg/kg i.p.) modulates the antipsychotic activity of M4 muscarinic receptor PAM VU0467154 and th at of the M1/M4 agonist xanomeline.
storage
Store at +4°C
VU0469650 Preparation Products And Raw materials
Raw materials
Preparation Products
VU0469650 Suppliers
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