ChemicalBook > CAS DataBase List > MD2-IN-1

MD2-IN-1

Product Name: MD2-IN-1
CAS No.: 111797-22-9
Chemical Name: MD2-IN-1
Synonyms: MDK7229;MDK 7229;MD2-IN-1;MD2 inhibitor 1;MD2-IN-1, 10 mM in DMSO;MD2-IN-1; MDK7229; MDK 7229; MDK 7229;1-(3,4-Dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one;2-Propen-1-one, 1-(3,4-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-;inhibit,Inhibitor,MD2IN1,Toll-like Receptor (TLR),MD-2-IN-1,MD2 IN 1
CBNumber: CB93373067
Molecular Formula: C20H22O6
Formula Weight: 358.39
MOL File: 111797-22-9.mol

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MD2-IN-1 Property

Melting point:: 131-132 °C
Boiling point:: 521.3±50.0 °C(Predicted)
Density: 1.156±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 50 mg/mL (139.51 mM);Water : < 0.1 mg/mL (insoluble)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-7984
Product name: MD2-IN-1
Purity: 99.85%
Packaging: 1mg
Price: $132
Updated: 2021/12/16

ChemScene

Product number: CS-7984
Product name: MD2-IN-1
Purity: 99.85%
Packaging: 5mg
Price: $396
Updated: 2021/12/16

ChemScene

Product number: CS-7984
Product name: MD2-IN-1
Purity: 99.85%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

ChemScene

Product number: CS-7984
Product name: MD2-IN-1
Purity: 99.85%
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

ChemScene

Product number: CS-7984
Product name: MD2-IN-1
Purity: 99.85%
Packaging: 100mg
Price: $2520
Updated: 2021/12/16

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MD2-IN-1 Chemical Properties,Usage,Production

Uses

MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 μM for the recombinant human MD2 (rhMD2).

Biological Activity

MD2-IN-1 is an inhibitor of myeloid differentiation protein 2 (MD2) with a KD value of 189 μM.

in vitro

Myeloid differentiation protein 2 (MD2) is a co-receptor of TLR4. Among those derivatives, MD2-IN-1 (compound 20) shows the strongest inhibitory effect on LPS-induced expression of both TNF-α and IL-6. Compare to the vehicle, LPS alone largely increases the amount of TLR4/MD2 complex, while pretreatment with MD2-IN-1 inhibits the increase of TLR4/MD2 complex to the vehicle level. SPR analysis shows that MD2-IN- 1 exhibits recognizable binding to rhMD2 protein in a dose-dependent manner, with a KD value of 189 μM, while the KD value of xanthohumol binding to MD2 is 460 μM. Pre-treatment with different doses of MD2-IN-1 dose-dependently FITC-LPS binding to MD2 in cell surface membranes reduces FITC-LPS binding to MD2 in cell surface membranes, with a 65% inhibition at 10 μM in terms of mean fluorescence intensity. Pretreatment with MD2-IN-1 also dose-dependently blocks LPS-induced MAPK phosphorylation in the MPMs.

in vivo

Administration of MD2-IN-1 evidently reduces the LPS-induced increase in protein concentrations in BALF. The lung wet/dry weight ratio is markedly higher in the LPS-treated group than the control group, and MD2- IN-1 treatment reduces LPS-induced pulmonary edema. LPS also causes observable lung histopathologic changes, including areas of inflammatory infiltration, hemorrhage, interstitial edema, thickening of the alveolar wall, and lung tissue destruction. These histopathological changes are ameliorated in the MD2- IN-1 treatment group.

target

Target	Value
MD2 ()	189 μM(Kd)

IC 50

TLR4

References

[1] Zhang Y, et al. Discovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury. Sci Rep. 2016 Apr 27;6:25130. DOI:10.1038/srep25130

MD2-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from MD2-IN-1 manufacturers

Career Henan Chemical Co

Product: MD2-IN-1 111797-22-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-23

111797-22-9, MD2-IN-1Related Search:

MD2-IN-1

MD2 inhibitor 1

MD2-IN-1; MDK7229; MDK 7229; MDK 7229

MDK 7229

MDK7229

2-Propen-1-one, 1-(3,4-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-

inhibit,Inhibitor,MD2IN1,Toll-like Receptor (TLR),MD-2-IN-1,MD2 IN 1

1-(3,4-Dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one

MD2-IN-1, 10 mM in DMSO

111797-22-9