Aminooxy-PEG1-azide
- Product Name
- Aminooxy-PEG1-azide
- CAS No.
- 2100306-70-3
- Chemical Name
- Aminooxy-PEG1-azide
- Synonyms
- Aminooxy-PEG1-azide
- CBNumber
- CB93373557
- Molecular Formula
- C4H10N4O2
- Formula Weight
- 146.15
- MOL File
- 2100306-70-3.mol
Aminooxy-PEG1-azide Property
- form
- Liquid
- color
- Colorless to light yellow
N-Bromosuccinimide Price
- Product number
- BP-23596
- Product name
- Aminooxy-PEG1-azide
- Purity
- 98%
- Packaging
- 100mg
- Price
- $340
- Updated
- 2021/12/16
Aminooxy-PEG1-azide Chemical Properties,Usage,Production
Description
Aminooxy-PEG1-azide is a short PEG linkerwith two functional groups, aminooxy (ONH2) and azide(N3). Aminooxy group can be used in bioconjugation by reaction with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.
Uses
Aminooxy-PEG1-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Aminooxy-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs
References
[1] Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228. DOI:10.1016/j.bmc.2019.115228
Aminooxy-PEG1-azide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Aminooxy-PEG1-azide manufacturers
- Product
- Aminooxy-PEG1-azide 2100306-70-3
- Price
- US $0.00/mg
- Min. Order
- 500mg
- Purity
- >98.00%
- Supply Ability
- 500mg
- Release date
- 2024-03-22