DBCO-PEG4-acid
- Product Name
- DBCO-PEG4-acid
- CAS No.
- 2110448-99-0
- Chemical Name
- DBCO-PEG4-acid
- Synonyms
- 4,7,10,13-Tetraoxa-17-azaeicosanoic acid, 20-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-16,20-dioxo-
- CBNumber
- CB93373603
- Molecular Formula
- C30H36N2O8
- Formula Weight
- 552.62
- MOL File
- 2110448-99-0.mol
DBCO-PEG4-acid Property
- Boiling point:
- 839.7±65.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- solubility
- Soluble in DMSO, DMF, DCM
- pka
- 4.28±0.10(Predicted)
- form
- Liquid
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P370+P378In case of fire: Use … for extinction.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- BP-23760
- Product name
- DBCO-NHCO-PEG4-acid
- Purity
- 98%
- Packaging
- 25mg
- Price
- $175
- Updated
- 2021/12/16
DBCO-PEG4-acid Chemical Properties,Usage,Production
Description
DBCO-NHCO-PEG4-acid is an analog of DBCO-Acid with a hydrophilic PEG spacer arm, which improves water solubility. This reagent is a non-activated building block with enhanced solubility in aqueous media and can thus be used to derivatize amine-containing molecule through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions.
Uses
DBCO-PEG4-acid is a a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
DBCO-PEG4-acid Preparation Products And Raw materials
Raw materials
Preparation Products
DBCO-PEG4-acid Suppliers
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