t-Boc-aminooxy-PEG6-propargyl
- Product Name
- t-Boc-aminooxy-PEG6-propargyl
- CAS No.
- 2093152-83-9
- Chemical Name
- t-Boc-aminooxy-PEG6-propargyl
- Synonyms
- t-Boc-aminooxy-PEG6-propargyl;3,6,9,12,15,18,21-Heptaoxa-2-azatetracos-23-ynoic acid, 1,1-dimethylethyl ester
- CBNumber
- CB93373779
- Molecular Formula
- C20H37NO9
- Formula Weight
- 435.51
- MOL File
- 2093152-83-9.mol
t-Boc-aminooxy-PEG6-propargyl Property
- Density
- 1.090±0.06 g/cm3(Predicted)
N-Bromosuccinimide Price
- Product number
- BP-23474
- Product name
- t-Boc-aminooxy-PEG6-propargyl
- Purity
- 98%
- Packaging
- 250mg
- Price
- $480
- Updated
- 2021/12/16
t-Boc-aminooxy-PEG6-propargyl Chemical Properties,Usage,Production
Description
t-Boc-aminooxy-PEG6-propargyl is a bifunctional linker molecule. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The protected aminooxy can be deprotected under mild acidic conditions and then can react with an aldehyde.. The hydrophilic PEG spacer increases solubility in aqueous media.
Uses
t-Boc-aminooxy-PEG6-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. t-Boc-aminooxy-PEG6-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
t-Boc-aminooxy-PEG6-propargyl Preparation Products And Raw materials
Raw materials
Preparation Products
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