ChemicalBook > CAS DataBase List > 4-acetamido-N-(2-amino-5-(thiophen-2-yl)phenyl)benzamide

4-acetamido-N-(2-amino-5-(thiophen-2-yl)phenyl)benzamide

Product Name
4-acetamido-N-(2-amino-5-(thiophen-2-yl)phenyl)benzamide
CAS No.
849234-64-6
Chemical Name
4-acetamido-N-(2-amino-5-(thiophen-2-yl)phenyl)benzamide
Synonyms
151025;Merck60;BRD 6929;Compound-60;BRD 6929;COMPOUND-60;BRD-6929, 10 mM in DMSO;4-Acetamido-N-[2-amino-5-(2-thienyl)phenyl]benzamide;4-acetamido-N-(2-amino-5-(thiophen-2-yl)phenyl)benzamide;Benzamide, 4-(acetylamino)-N-[2-amino-5-(2-thienyl)phenyl]-;Inhibitor,mood-related,BRD-6929,Human immunodeficiency virus,HDAC,BRD6929,HDACi,BRD 6929,HIV,behavioral,inhibit,Histone deacetylases
CBNumber
CB93380135
Molecular Formula
C19H17N3O2S
Formula Weight
351.42
MOL File
849234-64-6.mol
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4-acetamido-N-(2-amino-5-(thiophen-2-yl)phenyl)benzamide Property

storage temp. 
Store at -20°C
solubility 
DMSO: soluble
form 
A solid
color 
Off-white to gray
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2521
Product name
BRD6929
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$89.3
Updated
2025/07/31
Sigma-Aldrich
Product number
SML2521
Product name
BRD6929
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$360
Updated
2025/07/31
ChemScene
Product number
CS-0020169
Product name
BRD-6929
Purity
99.55%
Packaging
5mg
Price
$380
Updated
2021/12/16
ChemScene
Product number
CS-0020169
Product name
BRD-6929
Purity
99.55%
Packaging
1mg
Price
$130
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0001409
Product name
4-(ACETYLAMINO)-N-[2-AMINO-5-(2-THIENYL)PHENYL]-BENZAMIDE
Purity
95.00%
Packaging
5MG
Price
$505.09
Updated
2021/12/16
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4-acetamido-N-(2-amino-5-(thiophen-2-yl)phenyl)benzamide Chemical Properties,Usage,Production

Uses

BRD-6929 is a potent, selective brain-penetrant inhibitor of class I histone deacetylase HDAC1 and HDAC2 inhibitor with IC50 of 1 nM and 8 nM, respectively. BRD-6929 shows high-affinity to HDAC1 and HDAC2 with Ki of 0.2 and 1.5 nM, respectively. BRD-6929 can be used for mood-related behavioral model research[3].

Definition

ChEBI: 4-acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamide is a member of benzamides.

Biological Activity

TPB is a potent and selective inhibitor of HDAC1 and HDAC2. TPB potentiates gnidimacrin activation of latent HIV-1 in cells.

in vivo

BRD-6929 (intraperitoneal injection; 45 mg/kg; single dose) exhibits a Cmax, T1/2 and AUC values of 17.7 μM, 7.2 hours, and 25.6 μM/L*hr, respectively in plasma. It shows a Cmax, T1/2 and AUC values of 0.83 μM, 6.4 hours, and 3.9 μM/L*hr, respectively in brain[1].BRD-6929 (intraperitoneal injection; 45 mg/kg; 10 days) acts as a deacetylase inhibitor in mouse brain. It significantly increases acetylation in each brain region by 1.5- to 2.0-fold compared to vehicle. The western blotting reveals that BRD-6929 significantly increases acetylation of histone H2B (tetra-acetylated), H3K9 and H4K12 in cortex, ventral striatum and hippocampus after the 10th daily treatment in adult male C57BL/6J mice[1].

IC 50

HDAC1: 1 nM (IC50); HDAC2: 8 nM (IC50); HDAC3: 458 nM (IC50); HIV-1

References

[1] Li-Huei Tsai, et al. Inhibition of hdac2 to promote memory. patent/US20120101147
[2] Schroeder FA, et al. A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and altersmouse behavior in two mood-related tests. PLoS One. 2013 Aug 14;8(8):e71323. DOI:10.1371/journal.pone.0071323
[3] Huang L, et al. Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor. ACS Med Chem Lett. 2018 Feb 6;9(3):268-273. DOI:10.1021/acsmedchemlett.8b00012

4-acetamido-N-(2-amino-5-(thiophen-2-yl)phenyl)benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-acetamido-N-(2-amino-5-(thiophen-2-yl)phenyl)benzamide Suppliers

China 47 United States 6 Global 53
ChemShuttle, Inc.
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0510-83588313-811 18800520310
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sales@chemshuttle.com
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China
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BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
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Shanghai GaoDao Pharmaceutical Co., Ltd.
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021-15001867143 15001867143
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1095570358@qq.com
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Shanghai EFE Biological Technology Co., Ltd.
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Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720
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Shanghai Rechem science Co., Ltd.
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Shanghai Chaolan Chemical Technology Center
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Sales@ATKchemical.com
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Beijing Jin Ming Biotechnology Co., Ltd.
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Fan De(Beijing) Biotechnology Co., Ltd.
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15911056312
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TargetMol Chemicals Inc.
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849234-64-6, 4-acetamido-N-(2-amino-5-(thiophen-2-yl)phenyl)benzamideRelated Search:


  • 4-acetamido-N-(2-amino-5-(thiophen-2-yl)phenyl)benzamide
  • BRD 6929
  • BRD 6929;COMPOUND-60
  • Compound-60
  • 151025
  • Merck60
  • Benzamide, 4-(acetylamino)-N-[2-amino-5-(2-thienyl)phenyl]-
  • Inhibitor,mood-related,BRD-6929,Human immunodeficiency virus,HDAC,BRD6929,HDACi,BRD 6929,HIV,behavioral,inhibit,Histone deacetylases
  • 4-Acetamido-N-[2-amino-5-(2-thienyl)phenyl]benzamide
  • BRD-6929, 10 mM in DMSO
  • 849234-64-6