KRN2

Product Name: KRN2
CAS No.: 1390654-28-0
Chemical Name: KRN2
Synonyms: KRN2;KRN2 (bromide);KRN2 bromide, 10 mM in DMSO;inhibit,Inhibitor,KRN2 bromide,KRN 2,KRN-2,KRN2,KRN-2 bromide
CBNumber: CB93382083
Molecular Formula: C27H23BrFNO4
Formula Weight: 524.39
MOL File: 1390654-28-0.mol

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KRN2 Property

storage temp.: Store at -20°C
solubility: DMSO : ≥ 60 mg/mL (114.42 mM)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC12186
Product name: KRN2bromide
Purity: >98%
Packaging: 100mg
Price: $850
Updated: 2021/12/16

DC Chemicals

Product number: DC12186
Product name: KRN2bromide
Purity: >98%
Packaging: 250mg
Price: $1700
Updated: 2021/12/16

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KRN2 Chemical Properties,Usage,Production

Description

KRN2 is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 0.1 μM.

KRN2 shows much stronger inhibition of NFAT5-dependent reporter activity in RAW 264.7 macrophages than does BBR; the IC50 value is 0.1 μM for KRN2 and 4 μM for BBR. In parallel, 0.5 μM of KRN2 significantly suppresses the LPS-stimulated increase in NFAT5 protein expression in RAW 264.7 macrophages. It is confirmed that LPS-induced NFAT5 mRNA and protein expression is nearly completely blocked by KRN2. Similarly, KRN2 inhibits the translocation of NFAT5 into the nucleus of RAW264.7 cells stimulated with LPS. KRN2 specifically represses LPS-induced NFAT5 promoter activity, whereas it fails to reduce high salt-induced NFAT5 activity in the same cells, which is consistent with the selective inhibition of TLR4-activated NFAT5, but not hypertonicity-induced NFAT5, by KRN2[1].

References

[1]. Han EJ, et al. Suppression of NFAT5-mediated Inflammation and Chronic Arthritis by Novel κB-binding Inhibitors. EBioMedicine. 2017 Apr;18:261-273.

KRN2 Preparation Products And Raw materials

Raw materials

Preparation Products

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KRN2 Suppliers

China 12 United States 3 Global 15

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
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Beijing xinyanhui pharmaceutical research and development co., LTD

Tel: 13969155946
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
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Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
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TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24641
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Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
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Sangon Biotech (Shanghai) Co.,Ltd.

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Email: Sales@sangon.com
Country: China
ProdList: 47240
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ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
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Biorbyt Ltd.

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Absin Bioscience Inc.

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Proteintech China

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Shanghai Hao Zhun Biological Technology Co., Ltd.

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1390654-28-0, KRN2Related Search:

KRN2

KRN2 (bromide)

inhibit,Inhibitor,KRN2 bromide,KRN 2,KRN-2,KRN2,KRN-2 bromide

KRN2 bromide, 10 mM in DMSO

1390654-28-0