2-Fluoro-4-methoxybenzoic acid
- Product Name
- 2-Fluoro-4-methoxybenzoic acid
- CAS No.
- 394-42-3
- Chemical Name
- 2-Fluoro-4-methoxybenzoic acid
- Synonyms
- BUTTPARK 32\01-80;RARECHEM AL BE 0456;2-FLUORO-P-ANISIC ACID;2-FLUORO-4-METHOXYBENZOIC ACID;2-Fluoro-4-methoxybenzoicAcid>Benzoic acid, 2-fluoro-4-methoxy-;2-Fluoro-4-methoxybenzoic acid 98%;4-Carboxy-3-fluoroanisole, 2-Fluoro-p-anisic acid
- CBNumber
- CB9338368
- Molecular Formula
- C8H7FO3
- Formula Weight
- 170.14
- MOL File
- 394-42-3.mol
2-Fluoro-4-methoxybenzoic acid Property
- Melting point:
- 194-198°C
- Boiling point:
- 257.8±20.0 °C(Predicted)
- Density
- 1.307±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 3.54±0.10(Predicted)
- color
- White to Light yellow to Light orange
- InChI
- InChI=1S/C8H7FO3/c1-12-5-2-3-6(8(10)11)7(9)4-5/h2-4H,1H3,(H,10,11)
- InChIKey
- UPWMPIKNUXTWFP-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C(OC)C=C1F
- CAS DataBase Reference
- 394-42-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36-37
- HazardClass
- IRRITANT
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F0572
- Product name
- 2-Fluoro-4-methoxybenzoic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $61
- Updated
- 2025/07/31
- Product number
- F0572
- Product name
- 2-Fluoro-4-methoxybenzoic Acid
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $242
- Updated
- 2025/07/31
- Product number
- F596118
- Product name
- 2-Fluoro-4-methoxybenzoic Acid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- F596118
- Product name
- 2-Fluoro-4-methoxybenzoic Acid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- F596118
- Product name
- 2-Fluoro-4-methoxybenzoic Acid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
2-Fluoro-4-methoxybenzoic acid Chemical Properties,Usage,Production
Chemical Properties
White solid
Antimicrobial activity
2-Fluoro-4-methoxybenzoic acid (2FMBA) is a potent antimicrobial agent that inhibits the growth of bacteria, fungi and other microorganisms. 2FMBA has significant antibacterial activity against Gram-positive and Gram-negative bacteria and also has significant antifungal activity against Candida albicans. 2FMBA is active in the presence of light and is a strong acid. It can be synthesized by refluxing benzoic acid with hydrazine, or by reacting an aromatic carboxylic acid with oxychloride. 2FMBA is used to treat bacterial infections such as E. coli, Staphylococcus, Salmonella, Shigella and Mycoplasma; fungal infections such as Candida albicans; and protozoal infections such as Giardia lamblia.
Synthesis
331-64-6
394-42-3
Step a) 2-fluoro-4-methoxybenzaldehyde (15 g, 97.4 mmol) was added to a mixture of silver oxide (Ag2O, 13.5 g, 58.4 mmol), sodium hydroxide (NaOH, 19.5 g, 487 mmol), and water (200 mL) preheated to 55 °C. The reaction mixture was stirred at 55 °C for 1 h. Subsequently, it was filtered and the precipitated solid was washed with hot water (10 mL). The filtrate was slowly added to 5N hydrochloric acid (HCl) pre-cooled to 0°C under vigorous stirring. The precipitated solid was filtered, washed with water and dried to give 2-fluoro-4-methoxybenzoic acid as a white solid (13.6 g, 82% yield, melting point 194-196°C); mass spectrum (MS) showed m/e 169 (M-H)+.
References
[1] Patent: US2003/199562, 2003, A1
[2] Patent: US2006/46968, 2006, A1. Location in patent: Page/Page column 28-29
[3] Journal of the Chemical Society, 1929, p. 1639
[4] RSC Advances, 2016, vol. 6, # 38, p. 32319 - 32327
2-Fluoro-4-methoxybenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Fluoro-4-methoxybenzoic acid manufacturers
- Product
- 2-Fluoro-4-methoxybenzoic acid 394-42-3
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-08
- Product
- 2-Fluoro-4-methoxybenzoic acid 394-42-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,100kg
- Release date
- 2019-07-04