RAPANONE

Product Name: RAPANONE
CAS No.: 573-40-0
Chemical Name: RAPANONE
Synonyms: RAPANONE;RAMATROBAN(RG);Rapanone, 10 mM in DMSO;2,5-dihydroxy-3-tridecyl-p-benzoquinone;2,5-DIHYDROXY-3-TRIDECYL-[1,4]BENZOQUINONE;2,5-Dihydroxy-3-tridecyl-2,5-cyclohexadiene-1,4-dione;2,5-dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione;2,5-dihydroxy-3-tridecyl-cyclohexa-2,5-diene-1,4-dione;2,5-Cyclohexadiene-1,4-dione, 2,5-dihydroxy-3-tridecyl-;antioxidant,anti-inflammatory,Bacterial,inhibit,anti-tumor,Phospholipase,antiparasiti,synovial,PLA2,Parasite,benzoquinone,antibacterial,Apoptosis,Rapanone,Inhibitor
CBNumber: CB9345395
Molecular Formula: C19H30O4
Formula Weight: 322.44
MOL File: 573-40-0.mol

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RAPANONE Property

Melting point:: 142-145°C
Boiling point:: 457.0±45.0 °C(Predicted)
Density: 1.099±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
pka: 2.84±0.50(Predicted)
form: Solid
color: Light yellow to orange

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FR137931
Product name: Rapanone
Packaging: 1mg
Price: $135
Updated: 2021/12/16

AK Scientific

Product number: 3825BA
Product name: Rapanone
Packaging: 1mg
Price: $232
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0019660
Product name: 2,5-DIHYDROXY-3-TRIDECYL-[1,4]BENZOQUINONE
Purity: 95.00%
Packaging: 1G
Price: $909.56
Updated: 2021/12/16

Arctom

Product number: AS184272
Product name: 2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione
Purity: 97%
Packaging: 100mg
Price: $100
Updated: 2021/12/16

Arctom

Product number: AS184272
Product name: 2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione
Purity: 97%
Packaging: 1g
Price: $373
Updated: 2021/12/16

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RAPANONE Chemical Properties,Usage,Production

Uses

Rapanone is a natural benzoquinone. Rapanone exhibits a broad spectrum of biological actions, including anti-tumor, antioxidant, anti-inflammatory, antibacterial and antiparasitic. Rapanone also is a potent and selective human synovial PLA2 inhibitor, with an IC50 of 2.6 μM[1][2][3][4].

Definition

ChEBI: Rapanone is a member of dihydroxy-1,4-benzoquinones.

in vivo

Rapanone (2.5-10 mg/kg; i.p.) exhibits anti-inflammatory effects in the carrageenan paw oedema model in mice^[4].

IC 50

PLA2: 2.6 μM (IC₅₀)

References

[1] Andreu GLP, et, al. Rapanone, a naturally occurring benzoquinone, inhibits mitochondrial respiration and induces HepG2 cell death. Toxicol In Vitro. 2020 Mar;63:104737. DOI:10.1016/j.tiv.2019.104737
[2] Morais LS, et, al. Antileishmanial compounds from Connarus suberosus: Metabolomics, isolation and mechanism of action. PLoS One. 2020 Nov 6;15(11):e0241855. DOI:10.1371/journal.pone.0241855
[3] Vega-Hernández K, et, al. Discerning the antioxidant mechanism of rapanone: A naturally occurring benzoquinone with iron complexing and radical scavenging activities. J Inorg Biochem. 2017 May;170:134-147. DOI:10.1016/j.jinorgbio.2017.02.019
[4] Ospina LF, et, al. Inhibition of acute and chronic inflammatory responses by the hydroxybenzoquinonic derivative rapanone. Planta Med. 2001 Dec;67(9):791-5. DOI:10.1055/s-2001-18839

RAPANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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RAPANONE Suppliers

China 36 South Korea 1 The Netherlands 1 United Kingdom 7 United States 7 Global 52

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

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Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
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Wuxi Zhongkun Biochemical Technology Co., Ltd.

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Email: sales@reading-chemicals.com
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Wuhan ChemFaces Biochemical Co., Ltd.

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Email: aileen@chemfaces.com
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Shanghai EFE Biological Technology Co., Ltd.

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Shanghai YuanYe Biotechnology Co., Ltd.

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Fax: QQ:3008007432
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Shandong Xiya Chemical Co., Ltd.

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Amadis Chemical Company Limited

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Email: sales@amadischem.com
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Chengdu Push Bio-Technology Co., Ltd.

Tel: 028-028-85370565-229-229 18080489829
Email: 18080489829@163.com
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Nanjing Digger Medical Technology Co. Ltd.

Tel: 025-025-51191215 18013836722
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573-40-0, RAPANONERelated Search:

RAPANONE(RG) 2-HYDROXY-5-METHOXY-6-METHYL-3-((E)-NONADEC-14-ENYL)-[1,4]BENZOQUINONE MAESAQUINONE RAPANONE ACETIC ACID 4-HYDROXY-2-METHYL-5-((E)-NONADEC-14-ENYL)-3,6-DIOXO-CYCLOHEXA-1,4-DIENYL ESTER 2-[13-(3-BUTYL-OXIRANYL)-TRIDECYL]-3,6-DIHYDROXY-5-METHYL-[1,4]BENZOQUINONE 2,5-DIMETHOXY-3-TRIDECYL-[1,4]BENZOQUINONE 2-HYDROXY-5-METHOXY-3-PENTADECYL-[1,4]BENZOQUINONE 2,5-DIHYDROXY-3-PENTADECYL-[1,4]BENZOQUINONE 2,5-DIMETHOXY-3-METHYL-6-((E)-NONADEC-14-ENYL)-[1,4]BENZOQUINONE 2,5-DIMETHOXY-3-METHYL-6-NONADECYL-[1,4]BENZOQUINONE 2,5-DIHYDROXY-3-METHYL-6-NONADECYL-[1,4]BENZOQUINONE 2-HYDROXY-5-METHOXY-3-TRIDECYL-[1,4]BENZOQUINONE ACETIC ACID 4-ACETOXY-2-METHYL-5-((E)-NONADEC-14-ENYL)-3,6-DIOXO-CYCLOHEXA-1,4-DIENYL ESTER

2,5-DIHYDROXY-3-TRIDECYL-[1,4]BENZOQUINONE

2,5-Dihydroxy-3-tridecyl-2,5-cyclohexadiene-1,4-dione

2,5-dihydroxy-3-tridecyl-cyclohexa-2,5-diene-1,4-dione

2,5-dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione

2,5-dihydroxy-3-tridecyl-p-benzoquinone

RAMATROBAN(RG)

RAPANONE

2,5-Cyclohexadiene-1,4-dione, 2,5-dihydroxy-3-tridecyl-

antioxidant,anti-inflammatory,Bacterial,inhibit,anti-tumor,Phospholipase,antiparasiti,synovial,PLA2,Parasite,benzoquinone,antibacterial,Apoptosis,Rapanone,Inhibitor

Rapanone, 10 mM in DMSO

573-40-0

Anthraquinones, Hydroquinones and Quinones