2-CHLORO-4,5-DIAMINOBENZOTRIFLUORIDE

Product Name: 2-CHLORO-4,5-DIAMINOBENZOTRIFLUORIDE
CAS No.: 157590-59-5
Chemical Name: 2-CHLORO-4,5-DIAMINOBENZOTRIFLUORIDE
Synonyms: 4-Chloro-5-(trifluoromethyl);3,4-Diamino-6-chlorobenzotrifluoride;2-CHLORO-4,5-DIAMINOBENZOTRIFLUORIDE;2-AMino-4-chloro-5-(trifluoroMethyl)aniline;4-Chloro-5-trifluoromethyl-o-phenylenediamine;4-CHLORO-5-TRIFLUOROMETHYL-BENZENE-1,2-DIAMINE;2-Amino-4-chloro-5-(trifluoromethyl)phenylamine;5-Chloro-4-(trifluoromethyl)benzene-1,2-diamine;1,2-Benzenediamine, 4-chloro-5-(trifluoromethyl)-;4-Chloro-5-trifluoromethyl-o-phenylenediamine,95%
CBNumber: CB9346468
Molecular Formula: C7H6ClF3N2
Formula Weight: 210.58
MOL File: Mol file

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2-CHLORO-4,5-DIAMINOBENZOTRIFLUORIDE Property

Melting point:: 61-63°
Boiling point:: 305.1±42.0 °C(Predicted)
Density: 1.510
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 2.30±0.10(Predicted)
form: Solid
color: White to brown
Water Solubility: Slightly soluble in water.

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HazardClass: 6.1
HS Code: 2921599090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: C385643
Product name: 4-Chloro-5-(trifluoromethyl)benzene-1,2-diamine
Packaging: 500mg
Price: $200
Updated: 2021/12/16

Matrix Scientific

Product number: 048565
Product name: 2-Amino-4-chloro-5-(trifluoromethyl)phenylamine
Purity: >95%
Packaging: 500mg
Price: $72
Updated: 2021/12/16

Matrix Scientific

Product number: 048565
Product name: 2-Amino-4-chloro-5-(trifluoromethyl)phenylamine
Purity: >95%
Packaging: 1g
Price: $110
Updated: 2021/12/16

Apolloscientific

Product number: PC5164
Product name: 4-Chloro-5-(trifluoromethyl)benzene-1,2-diamine
Purity: 97%
Packaging: 1g
Price: $111
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3830-7-07
Product name: 2-Chloro-4,5-diaminobenzotrifluoride
Purity: 97%
Packaging: 1g
Price: $122
Updated: 2021/12/16

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2-CHLORO-4,5-DIAMINOBENZOTRIFLUORIDE Chemical Properties,Usage,Production

Uses

4-Chloro-5-trifluoromethyl-o-phenylenediamine has application in dietary supplements, pharmaceutical or cosmeticeuticals.

Synthesis

35375-74-7

157590-59-5

General procedure for the synthesis of 2-chloro-4,5-diaminotrifluoromethylbenzene from 5-chloro-2-nitro-4-(trifluoromethyl)aniline: 5-chloro-2-nitro-4-(trifluoromethyl)aniline (2 g, 8.31 mmol) was dissolved in a solvent mixture of EtOH:H2O (5:1, 10 mL) at room temperature. Subsequently, SnCl2 (4.73 g, 24.9 mmol) was added to the solution. The reaction mixture was stirred at 80°C for 3 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction mixture was filtered through a bed of diatomaceous earth and the filtrate was concentrated under reduced pressure to afford 4-chloro-5-(trifluoromethyl)benzene-1,2-diamine as a yellow semi-solid product. Yield: 1.7 g, 97% yield. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 6.95 (s,1H), 6.88 (s,1H), 4.68-5.08 (bs,4H). Mass spectrometry (ESI-) analysis showed m/z 209.15 [M-H]-.

References

[1] Patent: WO2018/37223, 2018, A1. Location in patent: Page/Page column 118; 119
[2] Journal of Medicinal Chemistry, 1995, vol. 38, # 22, p. 4367 - 4379
[3] Patent: WO2004/35549, 2004, A1. Location in patent: Page 105
[4] Patent: WO2008/56150, 2008, A1. Location in patent: Page/Page column 182

2-CHLORO-4,5-DIAMINOBENZOTRIFLUORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-4,5-DIAMINOBENZOTRIFLUORIDE Suppliers

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157590-59-5, 2-CHLORO-4,5-DIAMINOBENZOTRIFLUORIDERelated Search:

2-AMino-4-chloro-5-(trifluoroMethyl)aniline

2-CHLORO-4,5-DIAMINOBENZOTRIFLUORIDE

4-CHLORO-5-TRIFLUOROMETHYL-BENZENE-1,2-DIAMINE

2-Amino-4-chloro-5-(trifluoromethyl)phenylamine

3,4-Diamino-6-chlorobenzotrifluoride

5-Chloro-4-(trifluoromethyl)benzene-1,2-diamine

4-Chloro-5-trifluoroMethyl-o-phenylenediaMine, 95%

4-Chloro-5-(trifluoromethyl)benzene-1,2-diamine 97%

4-Chloro-5-(trifluoromethyl)phenylene-1,2-diamine, 2-Chloro-4,5-diaminobenzotrifluoride

4-Chloro-5-(trifluoromethyl)

1,2-Benzenediamine, 4-chloro-5-(trifluoromethyl)-

4-Chloro-5-trifluoromethyl-o-phenylenediamine,95%

4-Chloro-5-trifluoromethyl-o-phenylenediamine

157590-59-5