ANTIPYRINECARBOXYLIC ACID
- Product Name
- ANTIPYRINECARBOXYLIC ACID
- CAS No.
- 83-10-3
- Chemical Name
- ANTIPYRINECARBOXYLIC ACID
- Synonyms
- 112688;NSC 59834;ANTIPYRIC ACID;RARECHEM AL BE 0663;ANTIPYRINECARBOXYLIC ACID;4-Antipyrinecarboxylic acid;1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolecarboxylic acid;1,5-dimethyl-3-oxo-2-phenylpyrazole-4-carboxylic acid;1,5-dimethyl-3-oxo-2-phenyl-pyrazole-4-carboxylic acid;3-keto-1,5-dimethyl-2-phenyl-pyrazole-4-carboxylic acid
- CBNumber
- CB9347243
- Molecular Formula
- C12H12N2O3
- Formula Weight
- 232.24
- MOL File
- Mol file
ANTIPYRINECARBOXYLIC ACID Property
- Melting point:
- 214 °C
- Boiling point:
- 363.0±52.0 °C(Predicted)
- Density
- 1.342±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 6.47±0.20(Predicted)
- Appearance
- White to yellow Solid
Safety
- HS Code
- 2933119000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- S366692
- Product name
- ANTIPYRIC ACID
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $185
- Updated
- 2025/07/31
- Product number
- S366692
- Product name
- ANTIPYRIC ACID
- Purity
- AldrichCPR
- Packaging
- 1G
- Price
- $179
- Updated
- 2024/03/01
- Product number
- B429863
- Product name
- 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylicAcid
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 077025
- Product name
- 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid
- Purity
- 97%
- Packaging
- 500mg
- Price
- $126
- Updated
- 2021/12/16
- Product number
- FD131726
- Product name
- 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
ANTIPYRINECARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
950-81-2
83-10-3
The general procedure for the synthesis of 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid from 4-antipyrinecarboxaldehyde is as follows: 1. 1-benzyl-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxaldehyde (1 g, 4.624 mmol) was dissolved in butanol at 0 °C to prepare a mixture. 2. An aqueous solution of NaClO2 (1.254 g, 13.873 mmol) and an aqueous solution of potassium dihydrogen phosphate monohydrate (3.146 g, 23.12 mmol) were slowly added to the above mixture. 3. the reaction mixture was slowly heated to room temperature with continuous stirring for 10 hours. 4. During the reaction, NaClO3 (1 g) was further added and the progress of the reaction was monitored. 5. After addition of sodium chlorite, stirring of the reaction mixture was continued followed by extraction with ethyl acetate. 6. The organic layer was washed, dried with Na2SO4 and filtered. 7. The filtrate was concentrated under reduced pressure to give a residue. 8. The residue was washed with hexane solution of 20% ethyl acetate to afford the target compound 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid as a white solid (808 mg, 3.48 mmol, 75% yield). Product characterization data: 1H NMR (400 MHz, DMSO): δ 12.22 (br s, 1H), 7.61-7.42 (m, 5H), 3.36 (s, 3H), 2.59 (s, 3H).
References
[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 5, p. 1858 - 1867
[2] Patent: US2011/183983, 2011, A1. Location in patent: Page/Page column 20-21
[3] Pharmazie, 1956, vol. 11, p. 191,193
[4] Justus Liebigs Annalen der Chemie, 1949, vol. 563, p. 1,9
[5] Chemical and Pharmaceutical Bulletin, 1958, vol. 6, p. 374,376
ANTIPYRINECARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
ANTIPYRINECARBOXYLIC ACID Suppliers
- Tel
- 021-61312847 13636370518
- Fax
- 021-55068248
- shyysw007@163.com
- Country
- China
- ProdList
- 4999
- Advantage
- 60
- Tel
- 792-3901125 13222993784
- Fax
- 0512-62575043
- sales@unite-pharm.com
- Country
- China
- ProdList
- 311
- Advantage
- 56
- Tel
- 0371-0371-55629727 13323845623
- Fax
- 037155629727
- 2885676761@qq.com
- Country
- China
- ProdList
- 10110
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 025-58851090 15955137747
- Fax
- (6)02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 15949
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 18916696128
- service@snowpharm.com
- Country
- China
- ProdList
- 1369
- Advantage
- 58
- Tel
- 0516-0516-88997009 18651776937
- 4164357@qq.com
- Country
- China
- ProdList
- 3204
- Advantage
- 58
- Tel
- 13981836672
- 2560370848@qq.com
- Country
- China
- ProdList
- 2807
- Advantage
- 58
- Tel
- +86 028-84641798 15982321820
- abby@arkpharm.com
- Country
- China
- ProdList
- 10000
- Advantage
- 58
View Lastest Price from ANTIPYRINECARBOXYLIC ACID manufacturers
- Product
- ANTIPYRINECARBOXYLIC ACID 83-10-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-02