ChemicalBook > CAS DataBase List > 5-FORMYL-2-THIOPHENECARBOXYLIC ACID

5-FORMYL-2-THIOPHENECARBOXYLIC ACID

Product Name
5-FORMYL-2-THIOPHENECARBOXYLIC ACID
CAS No.
4565-31-5
Chemical Name
5-FORMYL-2-THIOPHENECARBOXYLIC ACID
Synonyms
AKOS MSC-0225;AURORA KA-6755;5-FORMYLTHENOIC ACID;5-formyl-2-thiophenecarboxylate;2-Formyl-5-thiophenecarboxylic acid;5-FORMYL-2-THIOPHENECARBOXYLIC ACID;5-FORMYL-THIOPHEN-2-CARBOXYLIC ACID;5-Carboxy-2-thiophenecarboxaldehyde;5-FORMYL-THIOPHENE-2-CARBOXYLIC ACID;5-Formyl-2-thiophenecarboxylicAcid>
CBNumber
CB9349393
Molecular Formula
C6H4O3S
Formula Weight
156.16
MOL File
4565-31-5.mol
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5-FORMYL-2-THIOPHENECARBOXYLIC ACID Property

Melting point:
169 °C
Boiling point:
371.4±27.0 °C(Predicted)
Density 
1.514±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
3.05±0.10(Predicted)
color 
Light yellow to Brown
InChI
InChI=1S/C6H4O3S/c7-3-4-1-2-5(10-4)6(8)9/h1-3H,(H,8,9)
InChIKey
VFEAMMGYJFFXKV-UHFFFAOYSA-N
SMILES
C1(C(O)=O)SC(C=O)=CC=1
CAS DataBase Reference
4565-31-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-36
Safety Statements 
26-36
Hazard Note 
Irritant
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
F0336
Product name
5-Formyl-2-thiophenecarboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$85
Updated
2025/07/31
TCI Chemical
Product number
F0336
Product name
5-Formyl-2-thiophenecarboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$215
Updated
2025/07/31
TRC
Product number
F701050
Product name
5-FormylthenoicAcid
Packaging
25mg
Price
$125
Updated
2021/12/16
SynQuest Laboratories
Product number
6H21-1-X0
Product name
5-Formylthiophene-2-carboxylic acid
Packaging
1g
Price
$93
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK424250
Product name
5-Formyl-2-thiophenecarboxylic Acid
Purity
98%
Packaging
1g
Price
$129
Updated
2021/12/16
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5-FORMYL-2-THIOPHENECARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

Bright red solid

Uses

5-Formyl-2-thiophenecarboxylic acid is a thiophene derivative as immunomodulating agents useful in the treatment of autoimmune diseases.

Synthesis

67808-64-4

4565-31-5

General procedure for the synthesis of 5-formyl-2-thiophenecarboxylic acid from methyl 5-formylthiophene-2-carboxylate: the compound methyl 5-formylthiophene-2-carboxylic acid (2 g, 12.8 mmol) was dissolved in 200 mL of a mixed solvent (THF:H2O = 1:1), and the hydrolysis reaction was carried out by adding KOH (1.1 g, 19.2 mmol). Upon completion of the reaction, THF was removed by distillation under reduced pressure.Subsequently, the pH of the aqueous layer was adjusted to 1-2 with 1N HCl solution and extracted with ethyl acetate (200 mL × 5), resulting in the target compound 5-formyl-2-thiophenecarboxylic acid (1.2 g, 59% yield).1H NMR (300 MHz, CDCl3) δ 10.00 (s, 1H), 7.93- 7.92 (d, J = 3.92 Hz, 1H), 7.78-7.77 (d, J = 3.9 Hz, 1H).13C NMR (300 MHz, CDCl3) δ 182.2, 163.30, 141.57, 139.70, 133.79, 132.

References

[1] Patent: WO2004/37808, 2004, A1. Location in patent: Page 14-15; 93

5-FORMYL-2-THIOPHENECARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

2-Thiophenecarboxaldehyde Benzene N,N-Dimethylethylenediamine 1,2-Dimethoxyethane n-Butyllithium

Preparation Products

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5-FORMYL-2-THIOPHENECARBOXYLIC ACID Suppliers

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View Lastest Price from 5-FORMYL-2-THIOPHENECARBOXYLIC ACID manufacturers

Hinova Pharma
Product
5-FORMYL-2-THIOPHENECARBOXYLIC ACID 4565-31-5
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99.0
Supply Ability
1000kg
Release date
2025-07-01
Career Henan Chemical Co
Product
5-FORMYL-2-THIOPHENECARBOXYLIC ACID 4565-31-5
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2020-01-08

4565-31-5, 5-FORMYL-2-THIOPHENECARBOXYLIC ACIDRelated Search:

5-Formyl-2-thiophenecarboxylic acid methyl ester 2,5-Thiophenedicarboxylic acid 3,4-Dihydroxy-thiophene-2,5-dicarboxylic acid dimethyl ester 5-FORMYL-2-THIOPHENECARBOXYLIC ACID 5-Acetylthiophene-2-carboxylic acid 2,5-Dicarboxylic acid-3,4-ethylenedioxythiophene Thieno[3,4-b]-1,4-dioxin-5,7-dicarboxylic acid, 2,3-dihydro-, diethyl ester 2-CHLORO-5-(5-ETHOXYCARBONYL-2-THENOYL)PYRIDINE 2-CHLORO-3-(5-ETHOXYCARBONYL-2-THENOYL)PYRIDINE 2,5-Thiophenedicarboxylic acid dimethyl ester THIOPHENE-2,5-DICARBOXYLIC ACID DISODIUM SALT ETHYL 5-THENOYL-2-THIOPHENE CARBOXYLATE 2-Formyl-3-thiophenecarboxylic acid methyl ester 3-Formyl-2-thiophenecarboxylic acid methyl ester 2-Formyl-3-thiophenecarboxylic acid 5-Formyl-3-thiophenecarboxylic acid 4-Formyl-2-thiophenecarboxylic acid 3-formyl-2-thiophenecarboxylic acid

  • AKOS MSC-0225
  • 5-FORMYLTHENOIC ACID
  • 5-FORMYL-THIOPHENE-2-CARBOXYLIC ACID
  • 5-FORMYL-THIOPHEN-2-CARBOXYLIC ACID
  • 5-FORMYL-2-THIOPHENECARBOXYLIC ACID
  • AURORA KA-6755
  • 5-Formyl-2-thiophenecarboxylic acid ,98%
  • 5-Carboxythiophene-2-carboxaldehyde, 2-Carboxy-5-formylthiophene, 5-Formyl-2-thenoic acid
  • 5-ForMyl-thiophene-2-carboxylic acid aMide
  • 5-formyl-2-thiophenecarboxylate
  • 2-Formyl-5-thiophenecarboxylic acid
  • 5-Formyl-2-thiophenecarboxylicAcid&gt
  • 2-Thiophenecarboxylic acid, 5-formyl-
  • 5-Carboxy-2-thiophenecarboxaldehyde
  • 2-methyl-1,3-thiazole-25-carboxylic acid
  • 4565-31-5
  • 4535-31-5
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds