FWMUIOJZHOPPDX-UHFFFAOYSA-N

Product Name: FWMUIOJZHOPPDX-UHFFFAOYSA-N
CAS No.: 1638526-21-2
Chemical Name: FWMUIOJZHOPPDX-UHFFFAOYSA-N
Synonyms: EMT inhibitor-1;FWMUIOJZHOPPDX-UHFFFAOYSA-N;EMT inhibitor1,EMT inhibitor 1;EMT inhibitor-1, 10 mM in DMSO;4-((4-(3,4-Dichlorophenyl)-1,2,5-thiadiazol-3-yl)oxy)butan-1-ol;1-Butanol, 4-[[4-(3,4-dichlorophenyl)-1,2,5-thiadiazol-3-yl]oxy]-
CBNumber: CB93509723
Molecular Formula: C12H12Cl2N2O2S
Formula Weight: 319.21
MOL File: 1638526-21-2.mol

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FWMUIOJZHOPPDX-UHFFFAOYSA-N Property

Boiling point:: 443.3±45.0 °C(Predicted)
Density: 1.415±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 5.6 mg/mL (17.54 mM)
form: Solid
pka: 14.96±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0021073
Product name: EMTinhibitor-1
Purity: 98.71%
Packaging: 5mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0021073
Product name: EMTinhibitor-1
Purity: 98.71%
Packaging: 10mg
Price: $750
Updated: 2021/12/16

ChemScene

Product number: CS-0021073
Product name: EMTinhibitor-1
Purity: 98.71%
Packaging: 25mg
Price: $1500
Updated: 2021/12/16

DC Chemicals

Product number: DC12273
Product name: EMTinhibitor-1
Purity: >98%
Packaging: 100mg
Price: $950
Updated: 2021/12/16

DC Chemicals

Product number: DC12273
Product name: EMTinhibitor-1
Purity: >98%
Packaging: 1g
Price: $3800
Updated: 2021/12/16

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FWMUIOJZHOPPDX-UHFFFAOYSA-N Chemical Properties,Usage,Production

Uses

EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.

in vivo

EMT inhibitor-1 (C19) (intraperitoneal injection; 5-20 mg/kg) exerts strong antitumor activity in a mouse tumor model. Mechanistically, EMT inhibitor-1 induces GSK3-β–mediated degradation of the Hippo transducer TAZ, through activation of the Hippo kinases Mst/Lats and the tumor suppressor kinase AMPK upstream of the degradation complex^[1].C19 is dissolved in the vehicle solution (100 μL of DMEM containing 5% dimethyl sulfoxide).

References

[1] Basu D, et al. Identification, mechanism of action, and antitumor activity of a small molecule inhibitor of hippo, TGF-β, and Wnt signaling pathways. Mol Cancer Ther. 2014 Jun;13(6):1457-67. DOI:10.1158/1535-7163.MCT-13-0918

FWMUIOJZHOPPDX-UHFFFAOYSA-N Preparation Products And Raw materials

Raw materials

Preparation Products

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1638526-21-2, FWMUIOJZHOPPDX-UHFFFAOYSA-NRelated Search:

FWMUIOJZHOPPDX-UHFFFAOYSA-N

EMT inhibitor-1

1-Butanol, 4-[[4-(3,4-dichlorophenyl)-1,2,5-thiadiazol-3-yl]oxy]-

EMT inhibitor1,EMT inhibitor 1

4-((4-(3,4-Dichlorophenyl)-1,2,5-thiadiazol-3-yl)oxy)butan-1-ol

EMT inhibitor-1, 10 mM in DMSO

1638526-21-2