MMP-2 SUBSTRATE, FLUOROGENIC

Product Name
MMP-2 SUBSTRATE, FLUOROGENIC
Chemical Name
MMP-2 SUBSTRATE, FLUOROGENIC
Synonyms
390 MMP FRET SUBSTRATE III;MCA-PLA-NVA-DAP(DNP)-AR-NH2;MMP-2 SUBSTRATE, FLUOROGENIC;MCA-PRO-LEU-ALA-NVA-DPA-ALA-ARG-NH2;MCA-PRO-LEU-ALA-NVA-DAP(DNP)-ALA-ARG-NH2
CBNumber
CB9354821
Molecular Formula
C50H70N14O15
Formula Weight
1107.18
MOL File
Mol file
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MMP-2 SUBSTRATE, FLUOROGENIC Property

storage temp. 
-20°C
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SCP0192
Product name
MMP 2 Substrate, fluorogenic
Packaging
1MG
Price
$196
Updated
2023/06/20
Sigma-Aldrich
Product number
SCP0192
Product name
MMP 2 Substrate, fluorogenic
Packaging
5MG
Price
$726
Updated
2023/06/20
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MMP-2 SUBSTRATE, FLUOROGENIC Chemical Properties,Usage,Production

Uses

Matrix metalloproteinases (MMP) are a family of zinc-dependent endopeptidases that degrade matrix proteins. MMPs include collagenases, gelatinases, matrilysins, enamelysins, metalloelastases, stromelysins and other structural protein and receptor lysins. The activity of these enzymes is selectively inhibited or measured by appropriately labeled peptides. MCA-Pro-Leu-Ala-Nva-DNP-Dap-Ala-Arg-NH2; DNP-Pro-Leu-Gly-Met-Trp-Ser-Arg (DNP-PLGMWSR), Dnp-Pro-Leu-Gly-Leu-Trp-Ala-D-Arg-NH2 (DNP-PLGLWA-D-R-NH2), Dnp-Pro-Gln-Gly-Ile-Ala-Gly-Gln-D-Arg-OH (DNP-PQGIAGQ-D-R-OH) and MOCAc [(7-methoxy coumarin-4-yl) acetyl]-RPKPYANvaWMK(Dnp[2,4-dinitrophenyl])-NH(2) are substrates for matrix metalloproteinase 2.

General Description

Matrix metalloproteinases (MMPs) are localized to the nucleus, mitochondria, vesicles and cytoplasm. MMP family comprises of 25 members, of which 24 are present in mammals. MMPs are encoded as inactive enzymes and are localized to cell membranes. All MMP members possess pro domain (80 amino acids) and catalytic domains.

Biochem/physiol Actions

Matrix metalloproteinases (MMPs) are responsible for degrading membrane proteins, such as basal lamina proteins of cerebral blood vessels. Proteolysis of intracellular substrates by MMPs is associated with the innate immune system and apoptosis. They are also involved in disease conditions such as oncogenesis, cardiac, neurological and autoimmune disorders. MMPs are also associated with pathogenesis related to protein conformational changes. Elevated expression of a number of MMPs is observed in myocardial infarction and heart failure.

MMP-2 SUBSTRATE, FLUOROGENIC Preparation Products And Raw materials

Raw materials

Preparation Products

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MMP-2 SUBSTRATE, FLUOROGENIC Suppliers

China 8 Japan 1 United Kingdom 2 United States 5 Global 16
Creative Enzymes
Tel
--
Fax
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Email
info@creative-enzymes.com
Country
United States
ProdList
6057
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58
Riedel-de Haen AG
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Country
United States
ProdList
6773
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87
EMD Biosciences, Inc.
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technical@calbiochem.com
Country
United States
ProdList
6529
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66
American Peptide Company
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Email
sales@americanpeptide.com
Country
United States
ProdList
1718
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71
AnaSpec, Inc.
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Email
service@anaspec.com
Country
United States
ProdList
4871
Advantage
77

MMP-2 SUBSTRATE, FLUOROGENICRelated Search:


  • MCA-PRO-LEU-ALA-NVA-DAP(DNP)-ALA-ARG-NH2
  • MCA-PRO-LEU-ALA-NVA-DPA-ALA-ARG-NH2
  • MCA-PLA-NVA-DAP(DNP)-AR-NH2
  • 390 MMP FRET SUBSTRATE III
  • MMP-2 SUBSTRATE, FLUOROGENIC
  • peptide