Orexin A (bovine, human, mouse, rat)

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Orexin A (bovine, human, mouse, rat)

Structure Gene, mRNA, and precursor Pathophysiological implications Synthesis and release Receptors Agonists and Antagonists Biological functions

Product Name: Orexin A (bovine, human, mouse, rat)
CAS No.: 205640-90-0
Chemical Name: Orexin A (bovine, human, mouse, rat)
Synonyms: OREXIN A;HYPOCRETIN;Rat orexin A;Hypocretin 1;OREXIN A (HUMAN, RAT, MOUSE);Orexin A (human, mouse, rat);Rabbit Anti-Orexin A antibody;M.W. 3561.12 C152H243N47O44S4;OREXINS OREXIN A HUMAN, RAT, MOUSE;OREXIN A, BOVINE, HUMAN, MOUSE, RAT
CBNumber: CB9355020
Molecular Formula: C152H243N47O44S4
Formula Weight: 3561.1
MOL File: 205640-90-0.mol

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Orexin A (bovine, human, mouse, rat) Property

Density: 1.53±0.1 g/cm3(Predicted)
storage temp.: -15°C
solubility: Soluble to 1 mg/ml in sterile
form: crystalline solid
Water Solubility: Soluble in water at 1mg/ml
Sequence: Glp-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-IIE-Leu-Thr-Leu-NH2 (Disulfide bridge: Cys6-Cys12, Cys7-Cys14)

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Safety

WGK Germany: 3
HS Code: 2937190000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J65378
Product name: Orexin A, human, bovine, rat, mouse
Packaging: 0.5mg
Price: $450
Updated: 2021/12/16

Cayman Chemical

Product number: 15073
Product name: Orexin A (bovine, human, mouse, rat)
Purity: ≥95%
Packaging: 500μg
Price: $287
Updated: 2024/03/01

Cayman Chemical

Product number: 15073
Product name: Orexin A (bovine, human, mouse, rat)
Purity: ≥95%
Packaging: 1mg
Price: $486
Updated: 2024/03/01

Cayman Chemical

Product number: 15073
Product name: Orexin A (bovine, human, mouse, rat)
Purity: ≥95%
Packaging: 5mg
Price: $2280
Updated: 2024/03/01

Tocris

Product number: 1455
Product name: Orexin A human, rat, mouse
Packaging: 500U
Price: $535
Updated: 2021/12/16

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Orexin A (bovine, human, mouse, rat) Chemical Properties,Usage,Production

Structure

Orexin exists as two molecular forms, orexin-A and orexin-B, derived from the same 130-aa residue precursor (prepro-orexin). In mammals, orexin-A is a 33 aa residue peptide with an N-terminal glutamine cyclized to pyroglutamate, and two intrachain disulfide bonds that are fully conserved among tetrapods. Orexin-B is a linear 28 aa residue peptide. Orexin-B consists of two α-helices connected with a short linker. The C-termini of both orexins are amidated. Human orexin-A and orexin-B have 46% homology (13/28), with their C-terminal side in particular being conserved. Although it was thought originally that orexin has no functional or structural identity with any other known regulatory peptide, it is now considered to belong to the incretin gene family of peptides, including members of the secretin-glucagon superfamily such as growth hormone-releasing hormone, pituitary adenylate cyclase-activating polypeptide, vasoactive intestinal peptide, and glucagon-like peptides. The molecular structures of orexins are relatively well conserved among vertebrates, especially in the disulfide bond regions in orexin-A and the C-terminal side in both orexins. Although tetrapod orexin-A comprises 33 aa residues, orexin-A of goldfish and zebrafish is 14 aa residues longer due to an additional spacer sequence.

Gene, mRNA, and precursor

The human prepro-orexin gene (HCRT), located on chromosome 17 (17q21), consists of two exons and one intron. Orexin-A and -B are coded tandemly in the prepro-orexin mRNA. To date, orexin has been identified in vertebrates, but orexin-like sequences have not been identified in invertebrates.

Pathophysiological implications

The dual orexin receptor antagonist suvorexant has been approved by the US Food and Drug Administration (FDA) for insomnia. Dual orexin receptor agonists such as almorexant, lemborexant, filorexant, and SB-649868 have been proceeded clinical trial. Suvorexant and other dual orexin receptor antagonists are being explored in a number of other indications, including depression, anxiety disorders, pain conditions, and degenerative disorders such as Alzheimer’s disease.

Synthesis and release

Orexin-A and orexin-B are synthesized in neurons located in the lateral hypothalamus. Food restriction increases orexin mRNA and peptide content in the brain. In cultured hypothalamic orexin neurons, low glucose concentration in the medium triggers the synthesis of orexins.

Receptors

There are two types of orexin receptors: orexin receptor-1 and -2 (OX1R and OX2R). The orexin receptors are GPCRs with seven-transmembrane domains. The amino acid sequence homology of human orexin receptors is mutually 64%. Orexin-A binds to OX1R and OX2R with a high affinity, whereas orexin-B selectively binds to OX2R with a similar high affinity. The human OX1R gene is located on chromosome 1 (1p35), and the human OX2R gene is located on chromosome 6 (6q11). OX1R and OX2R activate Gq pathways to produce IP3 and an intracellular rise in Ca²⁺, or to stimulate the MAPK pathway. Furthermore, OX2R is able to modulate the intracellular concentration of cAMP by coupling to Gs and Gi proteins.

Agonists and Antagonists

[Ala¹¹, D-Leu¹⁵]-Orexin B and SB-668875 are OX2 specific agonists. Among orexin receptor antagonists, ACT-335827, SB-334867, and SB-408124 are OX1-specific antagonists; TCS-OX2-29, EMPA, and JNJ 10397049 are OX2-specific antagonists; and ACT-078573 (almorexant), MK-4305 (suvorexant), MK-6096 (filorexant), E-2006 (lemborexant), SB-649868, and TCS 1102 are dual antagonists. Further information regarding orexin receptor antagonists can be found in the review by Lebold and colleagues.

Biological functions

Although orexin was first reported as an appetite-stimulating hormone in mammals, further studies have revealed its multifunctional status. An important function of orexin is as a regulator of the sleep-wake cycle. Orexin affects monoaminergic neurons in the locus ceruleus, raphe nucleus, and ventral tegmental area to maintain wakefulness. Orexin systems have roles in regulating drinking behavior, locomotor activity, and sympathetic nervous system activation. Orexin contributes to the regulation of the endocrine system, elevating blood corticosterone levels, decreasing blood prolactin levels, and suppressing the gonadotropin-producing cells in the hypothalamus. In teleosts, the intracerebroventricular injection of orexin-A stimulates food consumption and locomotor activity in goldfish and zebrafish.

Uses

appetite regulation, wakefulness, locomotor activity, hypothalamic-pituitary-adrenal activity, and pain thresholds. Orexin signaling is activated by nutrient depletion, causing an increase in food intake by delaying the signals of satiety. It activates the orexin-1 and -2 receptors with equal affinity.

General Description

Orexin is a hypothalamic neuropeptide consisting of 33 or 28 aa residues. Orexin has a pleiotropic function regulating feeding behavior, the sleep-wake cycle, metabolism, locomotor activity, and the endocrine system through orexin receptors. Orexin (also known as hypocretin) was discovered by reverse pharmacology as an endogenous ligand for two orphan GPCRs in 1998.

Biological Activity

orexin a, a 33 amino acid hypothalamic neuropeptide, is an endogenous agonist at orexin-1 and -2 receptors[1]. it play a role in appetite regulation, wakefulness, locomotor activity, hypothalamic-pituitary-adrenal activity, and pain thresholds[2].orexin a (10 and 30 mg/kg i.v., 5 min pre-plantar test) increases the latency to thermally stimulated paw contraction to baseline levels. orexin a (3-30 mg/kg; i.v.; 5 min pre-test) significantly increases the reaction latency of intravenous reactions of 10 and 30 mg/kg[3].[1]. rodgers r j, ishii y, halford j c g, et al. orexins and appetite regulation. neuropeptides, 2002, 36(5): 303-325 .[2]. lang m, söll r m, dürrenberger f, et al. structure-activity studies of orexin a and orexin b at the human orexin 1 and orexin 2 receptors led to orexin 2 receptor selective and orexin 1 receptor preferring ligands. journal of medicinal chemistry, 2004, 47(5): 1153-1160.[3]. bingham s, et al. orexin-a, an hypothalamic peptide with analgesic properties. pain, 2001, 92(1-2): 81-90.

storage

-20°C

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View Lastest Price from Orexin A (bovine, human, mouse, rat) manufacturers

Wuhan Senwayer Century Chemical Co.,Ltd

Product: Orexin A Peptide(bovine, human, mouse, rat) 205640-90-0
Price: US $0.00/mg
Min. Order: 10mg
Purity: 99% min
Supply Ability: 20 tons
Release date: 2023-06-09

Career Henan Chemical Co

Product: Orexin A (bovine, human, mouse, rat) 205640-90-0
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-13

205640-90-0, Orexin A (bovine, human, mouse, rat)Related Search:

Orexin A (bovine, human, mouse, rat)

PYR-PRO-LEU-PRO-ASP-CYS-CYS-ARG-GLN-LYS-THR-CYS-SER-CYS-ARG-LEU-TYR-GLU-LEU-LEU-HIS-GLY-ALA-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-LEU-NH2

PYR-PRO-LEU-PRO-ASP-CYS-CYS-ARG-GLN-LYS-THR-CYS-SER-CYS-ARG-LEU-TYR-GLU-LEU-LEU-HIS-GLY-ALA-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-LEU-NH2 (DISULFIDE BRIDGE: 6-12 AND 7-14)

PYR-PLPDCCRQKTCSCRLYELLHAGAGNHAAGILTL-NH2

PYR-PLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2

PYR-PLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2 (DISULFIDE BRIDGE: 6-12 AND 7-14)

OREXINS OREXIN A HUMAN, RAT, MOUSE

OREXIN A, BOVINE, HUMAN, MOUSE, RAT

OREXIN A (HUMAN, RAT, MOUSE)

OREXIN-A (HUMAN) (RAT, MOUSE, BOVINE)

OREXIN A (HUMAN, BOVINE, MOUSE, RAT)

OREXIN A (HUMAN, BOVINE, RAT, MOUSE)

OREXIN A

PGLU-PRO-LEU-PRO-ASP-CYS-CYS-ARG-GLN-LYS-THR-CYS-SER-CYS-ARG-LEU-TYR-GLU-LEU-LEU-HIS-GLY-ALA-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-LEU-NH2

HYPOCRETIN

OREXIN A (HUMAN, BOVINE, CANINE, MOUSE, OVINE, PORCINE, RAT)

Hypocretin 1

M.W. 3561.12 C152H243N47O44S4

PYR-PRO-LEU-PRO-ASP-CYS-CYS-ARG-GLN-LYS-THR-CYS-SER-CYS-ARG-LEU-TYR-GLU-LEU-LEU-HIS-GLY-ALA-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-LEU-NH2(DISULFIDE BRIDGE: CYS6-CYS12, CYS7-CYS14)

Orexin A (huMan, bovine, canine, Mouse, ovine, porcine, rat) Hypocretin-1 (huMan, bovine, canine, Mouse, ovine, porcine, rat)

pGlu-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (Disulfide bridges Cys6-Cys12 and Cys7-Cys14)

Hypocretin-1 (huMan, bovine, canine, Mouse, ovine, porcine, rat)

Rat orexin A

Orexin A (human, mouse, rat)

L-Leucinamide, 5-oxo-L-prolyl-L-prolyl-L-leucyl-L-prolyl-L-α-aspartyl-L-cysteinyl-L-cysteinyl-L-arginyl-L-glutaminyl-L-lysyl-L-threonyl-L-cysteinyl-L-seryl-L-cysteinyl-L-arginyl-L-leucyl-L-tyrosyl-L-α-glutamyl-L-leucyl-L-leucyl-L-histidylglycyl-L-alanylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alan...

Orexin A (human, mouse, rat, bovine)

5-oxo-L-prolyl-L-prolyl-L-leucyl-L-prolyl-L-α-aspartyl-L-cysteinyl-L-cysteinyl-L-arginyl-L-glutaminyl-L-lysyl-L-threonyl-L-cysteinyl-L-seryl-L-cysteinyl-L-arginyl-L-leucyl-L-tyrosyl-L-α-glutamyl-L-leucyl-L-leucyl-L-histidylglycyl-L-alanylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl-L-Leucinamide cyclic (6→12),(7→14)-bis(disulfide) (9CI ACI)

Orexin A Peptide(bovine, human, mouse, rat)

Rabbit Anti-Orexin A antibody

205640-90-0

C152H243N47O44S4

C152H247N47O44S4

Peptide Receptors

hormones

Peptide

Orexin receptor