H-TYR-PRO-TRP-GLY-NH2

Product Name: H-TYR-PRO-TRP-GLY-NH2
CAS No.: 144450-13-5
Chemical Name: H-TYR-PRO-TRP-GLY-NH2
Synonyms: YPWG-NH2;TYR-W-MIF-I;TYR-W-MIF-1;(TYR0,TRP2)-MIF-I;[TYR0, TRP2]-MIF-1;TYR-PRO-TRP-GLY-NH2;H-TYR-PRO-TRP-GLY-NH2;Tyr-W-MIF-I, (Tyr0,Trp2)-MIF-I;tyrosyl-prolyl-tryptophyl-glycinamide;L-Tyrosyl-L-prolyl-L-tryptophylglycinamide
CBNumber: CB9362981
Molecular Formula: C27H32N6O5
Formula Weight: 520.58
MOL File: 144450-13-5.mol

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H-TYR-PRO-TRP-GLY-NH2 Property

Boiling point:: 1009.2±65.0 °C(Predicted)
Density: 1.380±0.06 g/cm3(Predicted)
storage temp.: -15°C
pka: 9.86±0.15(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: PEP0000261
Product name: [TYR1]-W-MIF-1
Purity: 95.00%
Packaging: 1MG
Price: $576.06
Updated: 2021/12/16

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H-TYR-PRO-TRP-GLY-NH2 Chemical Properties,Usage,Production

Uses

Tyr-W-MIF-1 is an opioid tetrapeptide with opiate and antiopiate activity. Tyr-W-MIF-1 can induce analgesia[1][2][5].

in vivo

Tyr-W-MIF-1 (i.c.v, 200 μg of 5 μL) induces prolonged analgesia in rats^[2].
Tyr-W-MIF-1 (i.t., 0.75 μg) induces analgesia, and is reversed by Naloxone^[3].

Animal Model:	Rats^[2]
Dosage:	200 μg in 5 μL
Administration:	Intracerebroventricular injection (i.c.v)
Result:	Prolonged analgesia, measured by latency to remove the tail from a heating element.

References

[1] Yang YR, et L. Opioid and antiopioid actions of Tyr-MIF-1, Tyr-W-MIF-1 and hemorphin-4 on rat locus coeruleus neurons: intracellular recording in vitro. Chin J Physiol. 1997 Sep 30;40(3):131-5. PMID:9434888
[2] Gergen KA, et al. Expression of the FOS proto-oncogene protein in brain after ICV administration of Tyr-W-MIF-1 (Tyr-Pro-Trp-Gly-NH2). Peptides. 1994;15(8):1505-11. DOI:10.1016/0196-9781(94)90130-9
[3] Gergen KA, et al. Intrathecal Tyr-W-MIF-1 produces potent, naloxone-reversible analgesia modulated by alpha 2-adrenoceptors. Eur J Pharmacol. 1996 Mar 18;298(3):235-9. DOI:10.1016/0014-2999(95)00823-3
[4] Harrison LM, et al. Tyr-W-MIF-1 attenuates down-regulation of opiate receptors in SH-SY5Y human neuroblastoma cells. J Pharmacol Exp Ther. 1998 Feb;284(2):611-7. PMID:9454805
[5] Erchegyi J, et al. Isolation of a novel tetrapeptide with opiate and antiopiate activity from human brain cortex: Tyr-Pro-Trp-Gly-NH2 (Tyr-W-MIF-1). Peptides. 1992 Jul-Aug;13(4):623-31. DOI:10.1016/0196-9781(92)90165-y

H-TYR-PRO-TRP-GLY-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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H-TYR-PRO-TRP-GLY-NH2 Suppliers

China 65 Germany 1 The Netherlands 1 United States 9 Global 76

GL Biochem (Shanghai) Ltd

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Nextpeptide Inc

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144450-13-5, H-TYR-PRO-TRP-GLY-NH2Related Search:

hemorphin 7 AETPTYPWRDAETGERC hemorphin 5 ENDOMORPHIN-1 VALORPHIN ENDOMORPHIN-1 (HUMAN, BOVINE) ACOH H2O LEU-VALORPHIN-ARG AC-GLY-ASP-TYR-SER-HIS-CYS-SER-PRO-LEU-ARG-TYR-TYR-PRO-TRP-TRP-LYS-CYS-THR-TYR-PRO-ASP-PRO-GLU-GLY-GLY-GLY-NH2, (DISULFIDE BOND) TRIFLUOROACETATE H-TYR-PRO-TRP-GLY-NH2

(TYR0,TRP2)-MELANOCYTE-STIMULATING HORMONE-RELEASE INHIBITING FACTOR

[TYR0, TRP2]-MELANOCYTE STIMULATING HORMONE-RELEASE INHIBITING FACTOR-1

[TYR0, TRP2]-MIF-1

(TYR0,TRP2)-MIF-I

TYR-W-MIF-1

TYR-W-MIF-I

TYR-PRO-TRP-GLY-NH2

YPWG-NH2

tyr-(trp2)-msh release inhibiting*factor trifluor

H-TYR-PRO-TRP-GLY-NH2

tyrosyl-prolyl-tryptophyl-glycinamide

alpha-melanotropin release inhibiting factor, Tyr-[Trp2]

Tyr-W-MIF-I, (Tyr0,Trp2)-MIF-I

Tyr-[Trp2]-Melanocyte Stimulating Hormone Release Inhibiting Factor trifluoroacetate salt

(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pyrrolidine-2-carboxamide

Glycinamide, L-tyrosyl-L-prolyl-L-tryptophyl-

L-Tyrosyl-L-prolyl-L-tryptophylglycinamide

(Tyr?,Trp?)-Melanocyte-Stimulating Hormone-Release Inhibiting Factor trifluoroacetate salt

144450-13-5

C27H32N6O5

Peptide