4-CYANOBENZENE-1-SULFONAMIDE
- Product Name
- 4-CYANOBENZENE-1-SULFONAMIDE
- CAS No.
- 3119-02-6
- Chemical Name
- 4-CYANOBENZENE-1-SULFONAMIDE
- Synonyms
- BUTTPARK 48\11-02;4-CYANOBENZENE-1-S;4-CYANOBENZENE-1-SUL;4-Sulphamoylbenzonitrile;p-cyano-benzenesulfonamid;4-CYANOBENZENESULFONAMIDE;4-Cyanobenzenesulphonamide;p-cyanobenzenesulphonamide;4-CYANOBENZENE-1-SULFONAMIDE;Benzenesulfonamide, 4-cyano-
- CBNumber
- CB9367133
- Molecular Formula
- C7H6N2O2S
- Formula Weight
- 182.2
- MOL File
- 3119-02-6.mol
4-CYANOBENZENE-1-SULFONAMIDE Property
- Melting point:
- 166 °C
- Boiling point:
- 400.7±47.0 °C(Predicted)
- Density
- 1.3827 (rough estimate)
- refractive index
- 1.6000 (estimate)
- RTECS
- DB1582000
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 9.57±0.10(Predicted)
- form
- solid
- color
- Off-white
- Water Solubility
- 1.111g/L(15 ºC)
- CAS DataBase Reference
- 3119-02-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36/37/39-36/37
- RIDADR
- 3276
- Hazard Note
- Harmful
- HazardClass
- IRRITANT
- HS Code
- 29350090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C962363
- Product name
- 4-Cyanobenzene-1-sulfonamide
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- C962363
- Product name
- 4-Cyanobenzene-1-sulfonamide
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C962363
- Product name
- 4-Cyanobenzene-1-sulfonamide
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 043670
- Product name
- 4-Cyanobenzenesulfonamide
- Purity
- 97%
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 021392
- Product name
- 4-Cyanobenzenesulfonamide
- Purity
- 97%
- Packaging
- 1g
- Price
- $44
- Updated
- 2021/12/16
4-CYANOBENZENE-1-SULFONAMIDE Chemical Properties,Usage,Production
Uses
4-Cyanobenzene-1-sulfonamide is a carbonic anhydrase inhibitor.
Synthesis
49584-26-1
3119-02-6
General procedure for the synthesis of p-cyanobenzenesulfonamide from 4-cyanobenzenesulfonyl chloride: 4-cyanobenzenesulfonyl chloride (10 mmol) was dissolved in anhydrous tetrahydrofuran (40 mL). A 30% aqueous ammonium hydroxide solution (3 mL) was slowly added to the reaction mixture at 0 °C, followed by stirring the reaction for 1 h at room temperature. After completion of the reaction, the reaction mixture was extracted with ethyl acetate and the organic phase was dried with anhydrous sodium sulfate. After concentration under reduced pressure, the white solid product p-cyanobenzenesulfonamide (1.6 g, 88% yield) was obtained by grinding with ether. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6) and 13C NMR (100 MHz, DMSO-d6): 1H NMR δ 8.11 (2H, d, J = 8.58 Hz), 8.02 (2H, d, J = 8.62 Hz), 7.69 (2H, bs, NH2, exchange with D2O); 13C NMR δ 148.9, 134.2, 127.4, 118.8, 115.3.
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 157, p. 1214 - 1222
[2] Zhurnal Obshchei Khimii, 1948, vol. 18, p. 110,112
[3] Chem.Abstr., 1948, p. 4976
[4] American Chemical Journal, 1896, vol. 18, p. 163,165
[5] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 16, p. 4397 - 4406
4-CYANOBENZENE-1-SULFONAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-CYANOBENZENE-1-SULFONAMIDE manufacturers
- Product
- 4-CYANOBENZENE-1-SULFONAMIDE 3119-02-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-11