CALCIMYCIN A23187 HEMIMAGNESIUM SALT
- Product Name
- CALCIMYCIN A23187 HEMIMAGNESIUM SALT
- CAS No.
- 72124-77-7
- Chemical Name
- CALCIMYCIN A23187 HEMIMAGNESIUM SALT
- Synonyms
- Calcimycin hemimagnesium;a23187hemimagnesium salt;CALCIMYCIN HEMIMAGNESIUM SALT;CALCIMYCIN A23187 HEMIMAGNESIUM SALT;calcium ionophore A23187 hemimagnesium;CALCIUM IONOPHORE A23187 HEMIMAGNESIUM SALT;CALCIUM IONOPHORE A23187 HEMIMAGNESIUM SALT BIOCHEMIKA;A23187 hemimagnesium salt, Antibiotic A 23187 hemimagnesium salt, Calcimycin hemimagnesium salt, Calimycin hemimagnesium salt
- CBNumber
- CB9367461
- Molecular Formula
- C58H72MgN6O12
- Formula Weight
- 1069.55
- MOL File
- 72124-77-7.mol
CALCIMYCIN A23187 HEMIMAGNESIUM SALT Property
- storage temp.
- 2-8°C
- solubility
- acetone: 5 mg/mL, clear, faintly yellow
- BRN
- 6765085
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36/37
- WGK Germany
- 3
- F
- 8
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C9400
- Product name
- Calcium Ionophore A23187 hemimagnesium salt
- Packaging
- 5mg
- Price
- $396
- Updated
- 2025/07/31
- Product number
- C9400
- Product name
- Calcium Ionophore A23187 hemimagnesium salt
- Packaging
- 10mg
- Price
- $687
- Updated
- 2023/06/20
- Product number
- CS-0129636
- Product name
- Calcimycin(hemimagnesium)
- Packaging
- 5mg
- Price
- $720
- Updated
- 2021/12/16
- Product number
- API0007831
- Product name
- CALCIUM IONOPHORE A23187 HEMIMAGNESIUM SALT
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $854.41
- Updated
- 2021/12/16
- Product number
- API0007831
- Product name
- CALCIUM IONOPHORE A23187 HEMIMAGNESIUM SALT
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $1044.78
- Updated
- 2021/12/16
CALCIMYCIN A23187 HEMIMAGNESIUM SALT Chemical Properties,Usage,Production
Uses
Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis[1][2][3][4].
in vivo
Calcimycin (A-23187) hemimagnesium (2.5 or 7.5 nM; intrapleurally) induces protein leakage[5].
| Animal Model: | Mice (ICR, 25-30 g)[5] |
| Dosage: | 2.5 or 7.5 nM |
| Administration: | Intrapleurally |
| Result: | Two hours after 2.5 nM, or three hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values. |
References
[1] Wu Q, et al. Characterization of the biosynthesis gene cluster for the pyrrole polyether antibiotic calcimycin(A23187) in Streptomyces chartreusis NRRL 3882. Antimicrob Agents Chemother. 2011 Mar;55(3):974-82. DOI:10.1128/AAC.01130-10
[2] Elliott JI, et al. IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in Tlymphocyte apoptosis. EMBO Rep. 2003 Feb;4(2):189-94. DOI:10.1038/sj.embor.embor722
[3] Engedal N, et al. Modulation of intracellular calcium homeostasis blocks autophagosome formation. Autophagy. 2013 Oct;9(10):1475-90. DOI:10.4161/auto.25900
[4] Mawatwal S, et al. Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner. Biochim Biophys Acta Gen Subj. 2017 Dec;1861(12):3190-3200. DOI:10.1016/j.bbagen.2017.09.010
[5] Wang JP, et al. Effect of norathyriol, isolated from Tripterospermum lanceolatum, on A23187-induced pleurisy and analgesia in mice. Naunyn Schmiedebergs Arch Pharmacol. 1994 Jul;350(1):90-5. DOI:10.1007/BF00180016
CALCIMYCIN A23187 HEMIMAGNESIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
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