ChemicalBook > CAS DataBase List > 3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid

3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid

Product Name
3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid
CAS No.
683808-78-8
Chemical Name
3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid
Synonyms
Poloppin;Poloppin >=98% (HPLC);1H-Pyrrole-2-propanoic acid, 5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-;3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid
CBNumber
CB93698449
Molecular Formula
C20H15BrF3NO2
Formula Weight
438.2378096
MOL File
683808-78-8.mol
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3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid Property

Boiling point:
536.7±50.0 °C(Predicted)
Density 
1.45±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 2mg/mL, clear
pka
4.62±0.10(Predicted)
form 
powder
color 
white to beige
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2186
Product name
Poloppin
Purity
≥98% (HPLC)
Packaging
5MG
Price
$81.3
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2186
Product name
Poloppin
Purity
≥98% (HPLC)
Packaging
25MG
Price
$411
Updated
2024/03/01
ChemScene
Product number
CS-0087610
Product name
Poloppin
Packaging
5mg
Price
$200
Updated
2021/12/16
ChemScene
Product number
CS-0087610
Product name
Poloppin
Packaging
10mg
Price
$340
Updated
2021/12/16
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3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid Chemical Properties,Usage,Production

Description

Poloppin is a modulator of protein-protein interactions of the mitotic polo-like kinases. It acts by targeting mutant KRAS, working synergistically with Crizotinib, an inhibitor of the c-MET receptor, against mutant KRAS-expressing cancer cells.

3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid Suppliers

China 8 Russia 1 United States 1 Global 10
VITAS-M LABORATORY, LTD.
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683808-78-8, 3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acidRelated Search:


  • 3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid
  • Poloppin
  • Poloppin >=98% (HPLC)
  • 1H-Pyrrole-2-propanoic acid, 5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-
  • 683808-78-8