1-(2,2,2-TRIFLUOROACETYL)-4-PIPERIDINECARBOXYLIC ACID

Product Name: 1-(2,2,2-TRIFLUOROACETYL)-4-PIPERIDINECARBOXYLIC ACID
CAS No.: 126501-70-0
Chemical Name: 1-(2,2,2-TRIFLUOROACETYL)-4-PIPERIDINECARBOXYLIC ACID
Synonyms: Albb-003872;N-TRIFLUOROACETYL ISONIPECOTIC ACID;1-(trifluoroacetyl)piperidine-4-carboxylic acid;1-(trifluoroacetyl)-4-piperidinecarboxylic acid;1-(2,2,2-Trifluoroacetyl)piperidine-4-carboxylic acid;1-(2,2,2-Trifluoro-acetyl)piperidin-4-carboxylic acid;1-(2,2,2-TRIFLUOROACETYL)-4-PIPERIDINECARBOXYLIC ACID;4-Piperidinecarboxylic acid, 1-(2,2,2-trifluoroacetyl)-;1-(trifluoroacetyl)-4-piperidinecarboxylic acid(SALTDATA: FREE)
CBNumber: CB9373370
Molecular Formula: C8H10F3NO3
Formula Weight: 225.17
MOL File: 126501-70-0.mol

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1-(2,2,2-TRIFLUOROACETYL)-4-PIPERIDINECARBOXYLIC ACID Property

Melting point:: 117 °C(Solv: hexane (110-54-3); ethyl ether (60-29-7))
Boiling point:: 386.6±42.0 °C(Predicted)
Density: 1.430±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 4.27±0.20(Predicted)
Appearance: White to off-white Solid

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B585513
Product name: 1-(2,2,2-Trifluoroacetyl)piperidine-4-carboxylicAcid
Packaging: 100mg
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H29-3-24
Product name: 1-(2,2,2-Trifluoroacetyl)piperidine-4-carboxylic acid
Packaging: 250mg
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 035919
Product name: 1-(Trifluoroacetyl)piperidine-4-carboxylic acid
Packaging: 500mg
Price: $87
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H29-3-24
Product name: 1-(2,2,2-Trifluoroacetyl)piperidine-4-carboxylic acid
Packaging: 1g
Price: $155
Updated: 2021/12/16

Apolloscientific

Product number: PC430312
Product name: 1-(2,2,2-Trifluoroacetyl)-4-piperidinecarboxylicacid
Packaging: 1g
Price: $180
Updated: 2021/12/16

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1-(2,2,2-TRIFLUOROACETYL)-4-PIPERIDINECARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

498-94-2

358-23-6

126501-70-0

Example 17A1 Synthesis of 1-(2,2,2-trifluoroacetyl)piperidine-4-carboxylic acid: to a solution of piperidine-4-carboxylic acid (4 g, 30.97 mmol) in dichloromethane (20 mL) was added slowly and dropwise to trifluoromethanesulfonic anhydride (7.8 g) at 0 °C. The reaction mixture was stirred at 0 °C overnight. After completion of the reaction, the reaction solution was diluted with water, the organic layer was separated and concentrated. The crude product was purified by silica gel column chromatography to afford the title compound in 70% yield as a white solid.

References

[1] Patent: WO2013/10453, 2013, A1. Location in patent: Page/Page column 109

1-(2,2,2-TRIFLUOROACETYL)-4-PIPERIDINECARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2,2,2-TRIFLUOROACETYL)-4-PIPERIDINECARBOXYLIC ACID Suppliers

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126501-70-0, 1-(2,2,2-TRIFLUOROACETYL)-4-PIPERIDINECARBOXYLIC ACIDRelated Search:

1-(Trifluoroacetyl)-2-piperidinecarboxylic acid butyl ester 1-(Trifluoroacetyl)-2-piperidinecarboxylic acid 1-methylpropyl ester 1-(Trifluoroacetyl)-4-piperidinecarboxylic acid (S)-1-methylpropyl ester 4-(TRIFLUOROACETYLAMINO)-1-BUTANOL Piperidine, 1-(fluoroacetyl)- (6CI,7CI,8CI,9CI) 4-PIPERIDINEMETHANOL, 1-(2-FLUOROETHYL) 1-(2,2,2-TRIFLUOROACETYL)-4-PIPERIDINECARBOXYLIC ACID 1-TRIFLUOROACETYL PIPERIDINE N,N-DIETHYL-2,2,2-TRIFLUOROACETAMIDE

1-(2,2,2-TRIFLUOROACETYL)-4-PIPERIDINECARBOXYLIC ACID

1-(trifluoroacetyl)piperidine-4-carboxylic acid

Albb-003872

1-(trifluoroacetyl)-4-piperidinecarboxylic acid(SALTDATA: FREE)

1-(2,2,2-Trifluoro-acetyl)piperidin-4-carboxylic acid

1-(2,2,2-Trifluoroacetyl)piperidine-4-carboxylic acid

1-(trifluoroacetyl)-4-piperidinecarboxylic acid

N-TRIFLUOROACETYL ISONIPECOTIC ACID

4-Piperidinecarboxylic acid, 1-(2,2,2-trifluoroacetyl)-

126501-70-0