H-PRO-NME2
- Product Name
- H-PRO-NME2
- CAS No.
- 29802-22-0
- Chemical Name
- H-PRO-NME2
- Synonyms
- N,N-Dimethylpyrrolidine-2-carboxamide;(S)-N,N-dimethylpyrrolidine-2-carboxamide;H-Pro-NMe;L-Pro-NMe2;H-PRO-NME2;PROLINE-NME2;H-PYRD(2)-NME2;H-PRO-NME2 USP/EP/BP;L-PROLINE DIMETHYLAMIDE;L-Proline dimethylamide98%
- CBNumber
- CB9376553
- Molecular Formula
- C7H14N2O
- Formula Weight
- 142.2
- MOL File
- 29802-22-0.mol
H-PRO-NME2 Property
- Boiling point:
- 250.2±29.0 °C(Predicted)
- Density
- 1.017±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- pka
- 9.18±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
- CAS DataBase Reference
- 29802-22-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P756020
- Product name
- L-ProlineDimethylamide
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 287818
- Product name
- L-Proline dimethylamide
- Packaging
- 500mg
- Price
- $333
- Updated
- 2021/12/16
- Product number
- P756020
- Product name
- L-ProlineDimethylamide
- Packaging
- 5g
- Price
- $365
- Updated
- 2021/12/16
- Product number
- 06200
- Product name
- L-Prolinedimethylamide,99%(Chiralpurity)
- Purity
- 99%(Chiralpurity)
- Packaging
- 250MG
- Price
- $33.6
- Updated
- 2021/12/16
- Product number
- 06200
- Product name
- L-Proline dimethylamide
- Purity
- ≥ 99% (Chiral purity)
- Packaging
- 1G
- Price
- $60
- Updated
- 2021/12/16
H-PRO-NME2 Chemical Properties,Usage,Production
Uses
L-Proline Dimethylamide is a reactant used in the synthesis of fluoromethylsulfonylaminophenyl propanamides as TRPV1 antagonists.
Synthesis
Take a clean beaker, add 180 mL of tetrahydrofuran solution, weigh and prepare N,N-dimethylpyrrolidine-2-carbonyl chloride dissolved in tetrahydrofuran, after dissolution, the solution was slowly added to the ice-water bath under the conditions of the dimethylamine tetrahydrofuran (which had been loaded into the clean three reaction flasks), the solid was precipitated immediately, and after addition, the stirring was continued for 4 hours at 35 , and the progress of the reaction was detected by thin-layer chromatography. After the reaction was completed and the reaction solution was cooled, 400 mL of ice water was added to the reaction, so that the product was completely precipitated, and a light yellow solid was obtained by filtration. After drying and recrystallization with anhydrous acetone, N,N-dimethylpyrrolidine-2-carboxamide was obtained.
H-PRO-NME2 Preparation Products And Raw materials
Raw materials
Preparation Products
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