THIONYL FLUORIDE Property

Melting point:

-129°C

Boiling point:

-44,8°C

Density 

(liq; -100°) 1.780; d (solid; -183°) 2.095

storage temp. 

-20°C

solubility 

reacts with H2O; soluble in benzene, ethyl ether

form 

colorless gas

color 

colorless

biological source

mouse

Water Solubility 

hydrolyzed by H2O; soluble ether, benzene [MER06]

Stability:

Reacts with water. Decomposes on heating.

EPA Substance Registry System

Thionyl fluoride (7783-42-8)

Safety

Hazard Codes 

C,F,T

Risk Statements 

20-34

Safety Statements 

36/37/39-45

RIDADR 

3308

Hazard Note 

Flammable/Corrosive/Toxic

TSCA 

T

HazardClass 

2.3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H310Fatal in contact with skin

H314Causes severe skin burns and eye damage

H330Fatal if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P302+P350IF ON SKIN: Gently wash with plenty of soap and water.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P320Specific treatment is urgent (see … on this label).

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

THIONYL FLUORIDE Chemical Properties,Usage,Production

Chemical Properties

colourless gas

Physical properties

A colourless gas, thermally stable up to red heat. Does not corrode Fe, Ni, Co, Hg, Si, Mn, B, Mg, Al or Zn below 125°C. Does not attack glass. Suffocating odour. Hydrolyzed very slowly in ice-cold water. M.p. -110.5°C, b.p. -43.7°C, tcr +88°C; d.(liq.)(—100°C) 1.780, d. (solid) (-183°C) 2.095.

Preparation

An iron bottle with a gas inlet tube serves as the reaction vessel. A second bottle is connected to the first to retain the unreacted HF. This is joined to a glass gas trap immersed in liquid nitrogen or a Dry Ice-acetone bath. A drying tube filled with KF is attached to exclude atmospheric moisture. The reaction vessel is filled with 500 g. of SOCl2 and 50 g of (catalyst), and anhydrous gaseous HF is introduced through the inlet tube. The HF is thoroughly absorbed, causing a mixture of SOF2 and HCl to evolve, which then is collected in the condensation trap. The reaction is so endothermic that the outside of the reaction vessel gradually becomes covered with ice. When all the SOCl2 has been consumed, more may be added without further SbCl5. Separation of the SOF2 from the HCl may be achieved either by distillation or by rapid bubbling of the gas mixture through ice-cold water, in which HCl is completely absorbed. At the same time, the SOF2 passes through with almost no decomposition. The gas is then dried over concentrated H2SO4 or over P2O5. Thionyl fluoride is stored under pressure in steel cylinders.
SOCl2 + 2 HF = SOF2 + 2 HCl

Biological Activity

Periostin (POSTN) participates in collagen fibrillogenesis. It plays a major role in the development of scar after traumatic spinal cord injury (SCI). Periostin controls the activities of fibrocyte to stimulate myofibroblast differentiation and lung fibrosis. It modulates the amount of collagen in tissue. Periostin also participates in the assembly of the extracellular matrix (ECM) architecture.

Safety Profile

Moderately toxic by inhalation. A severe irritant to skin, eyes, and mucous membranes. When heated to decomposition or on contact with water or steam it emits highly toxic and corrosive fumes of SOx and F-. See also FLUORIDES.