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(R)-2-PHENYLPIPERIDINE

Product Name
(R)-2-PHENYLPIPERIDINE
CAS No.
58613-54-0
Chemical Name
(R)-2-PHENYLPIPERIDINE
Synonyms
(R)-2-PHENYLPIPERIDINE;(2R)-2-phenylpiperidine;(R)-(+)-6-phenylpiperidine;(R)-2-Phenylpiperidine 95%;Piperidine, 2-phenyl-, (2R)-
CBNumber
CB9407604
Molecular Formula
C11H15N
Formula Weight
161.24
MOL File
Mol file
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(R)-2-PHENYLPIPERIDINE Property

Boiling point:
257.3±19.0 °C(Predicted)
Density 
0.967±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
form 
liquid
pka
9.74±0.10(Predicted)
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
900573
Product name
(R)-2-Phenylpiperidine
Purity
95%
Packaging
1G
Price
$697
Updated
2023/06/20
Sigma-Aldrich
Product number
900573
Product name
(R)-2-Phenylpiperidine
Purity
95%
Packaging
5G
Price
$1020
Updated
2023/01/07
TRC
Product number
P400183
Product name
(R)-2-Phenylpiperidine
Packaging
100mg
Price
$350
Updated
2021/12/16
Matrix Scientific
Product number
121952
Product name
(R)-2-Phenylpiperidine
Purity
>97%
Packaging
500mg
Price
$441
Updated
2021/12/16
Activate Scientific
Product number
AS116333
Product name
(R)-2-Phenylpiperidine
Purity
97+% ee
Packaging
1g
Price
$478
Updated
2021/12/16
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(R)-2-PHENYLPIPERIDINE Chemical Properties,Usage,Production

Description

(R)-2-Phenylpiperidine is an alkene that has been used in the desymmetrization of secondary amides to produce enantiopure products. It has been shown to be stereoselective. It could prepared from δ-Amino β-keto esters 3. The kinetic resolution of this compound is due to the formation of an enamine, which undergoes a 1,4-addition reaction with an aldoxime or piperidone.

Uses

Chiral building block developed using Liverpool ChiroChem-patented technology.

Synthesis

In a 10 mL one-necked round-bottomed flask equipped with a magnetic stir bar, rubber septum, and argon balloon was placed 0.033 g (0.19 mmol, 1 equiv.) of (R)-(+)-6-Phenylpiperidin-2-one and THF (1.2 mL). Lithium aluminum hydride (0.95 mL, 1.0 M solution in THF, 0.95 mmol) was added slowly via syringe and the reaction mixture was stirred at rt for 8 h. The solution was cooled to 0 °C, sat. Na2SO4 (0.17 mL) was added, stirred for 0.5 h at rt and the reaction mixture was filtered through Celite. The organic phases were concentrated and flash chromatography (7% MeOH/CH2Cl2) gave 0.025 g (82%) of (R)-2-phenylpiperidine as volatile oil.

(R)-2-PHENYLPIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-2-PHENYLPIPERIDINE Suppliers

China 47 India 2 United States 6 Global 55
Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
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0086-571-85864795
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sales@capotchem.com
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AstaTech (Chengdu) Pharma. Co., Ltd.
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028-85122536 15928766785
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LABTER PHARMATECH(BEIJING) CO.,LTD
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010-56330744 18310155299
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Sigma-Aldrich
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021-61415566 800-8193336
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Struchem Co., Ltd.
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SanoChem (Chengdu) Tech. Co., Ltd.
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sales@sano-chem.com
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TaiChem Taizhou Limited
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052386810091
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Shanghai SuperLan Chemcial Technique Centre
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021-2022843681 15618226720
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+86-21-51601218
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lucy@atkchemical.com
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China
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Shanghai Yihe Biological Technology Co., Ltd.
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17721395025
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021-68882955
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2423903095@qq.com
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China
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3990
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58

58613-54-0, (R)-2-PHENYLPIPERIDINERelated Search:

(R)-(+)-2-PHENOXYPROPIONIC ACID (R)-2-methyl-2-phenylpiperidine (S)-2-PHENYLPIPERIDINE

  • (R)-2-PHENYLPIPERIDINE
  • (R)-(+)-6-phenylpiperidine
  • Piperidine, 2-phenyl-, (2R)-
  • (R)-2-Phenylpiperidine 95%
  • (2R)-2-phenylpiperidine
  • 58613-54-0